A new furanosteroid from <i>Talaromyces</i> sp. lgt-4, a fungal endophyte isolated from <i>Tripterygium wilfordii</i>

Zhi, Kang-Kang; Yang, Zhiwei; Zhou, Shuangyan; Yao, Xiaojun; Li, Shuo; Zhang, Fei

doi:10.1080/14786419.2016.1138301

Cited by 19 publications

(2 citation statements)

References 11 publications

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“…The secondary metabolites of this genus have shown great potential in their chemical and bioactive diversity. Terpenoids, alkaloids, and polyketides with multiple bioactivities (including antibiotic, cytotoxic, and anti-HBV activity) have been reported as metabolites from Talaromyces (Hayashi et al, 2012;Kumar et al, 2013;Wu et al, 2015;Zhai et al, 2015;Fu et al, 2016;Guo et al, 2016;Xie et al, 2016;Zhao et al, 2016Zhao et al, , 2019Zhi et al, 2016;Cai et al, 2017;Küppers et al, 2017;Chen et al, 2018;Wang et al, 2018), with another review paper published in 2020 (Lan and Wu, 2020). Our investigation provides good FIGURE 3 | The unrooted phylogenetic tree constructed using all isolates based on β-tubulin gene sequences.…”

Section: Isolation and Phylogenetic Diversity Of Aciduric Fungi Associated With Thai Mangrove Sedimentmentioning

confidence: 58%

Bioactive Metabolites From Acid-Tolerant Fungi in a Thai Mangrove Sediment

et al. 2021

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Despite being potentially useful extremophile resources, there have been few reports on acid-tolerant fungi and their bioactive metabolites. Acidophilic/aciduric fungi (n = 237) were isolated from Thai mangrove sediments in an acidic medium. Using fungal identification technology (including morphologic observation, chemical screening, and sequence comparisons) all the isolates were identified and 41 representative isolates were selected for analysis of the phylogenetic relationships (ITS rDNA, β-tubulin, calmodulin, and actin gene sequences). There were seven genera identified – Penicillium; Aspergillus; Talaromyces; Cladosporium; Allophoma; Alternaria; and Trichoderma – in four taxonomic orders of the phylum Ascomycota, and Penicillium, Aspergillus, and Talaromyces were the dominant genera. Acidity tolerance was evaluated and 95% of the isolates could grow under extremely acidic conditions (pH 2). Six strains were classed as acidophilic fungi that cannot survive under pH 7, all of which had an extraordinarily close genetic relationship and belonged to the genus Talaromyces. This is the first report on the acidophilic characteristics of this genus. The antimicrobial, anti-tumor, and antiviral activities of the fermentation extracts were evaluated. Nearly three-quarters of the extracts showed cytotoxic activity, while less than a quarter showed antimicrobial or anti-H1N1 activity. The typical aciduric fungus Penicillium oxalicum OUCMDZ-5207 showed similar growth but completely different chemical diversity at pH 3 and 7. The metabolites of OUCMDZ-5207 that were obtained only at pH 3 were identified as tetrahydroauroglaucin (1), flavoglaucin (2), and auroglaucin (3), among which auroglaucin showed strong selective inhibition of A549 cells with an IC50 value of 5.67 μM. These results suggest that acid stress can activate silent gene clusters to expand the diversity of secondary metabolites, and the bioprospecting of aciduric/acidophilic microorganism resources in Thai mangrove sediments may lead to the discovery of compounds with potential medicinal applications.

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Section: Isolation and Phylogenetic Diversity Of Aciduric Fungi Associated With Thai Mangrove Sedimentmentioning

confidence: 58%

Bioactive Metabolites From Acid-Tolerant Fungi in a Thai Mangrove Sediment

et al. 2021

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“…As part of our ongoing research toward the discovery of secondary metabolites from marine-derived fungi [3,4,5,6,7,8], an endophytic fungal strain, Talaromyces islandicus EN-501, was selected for chemical investigation. Recently, several new natural products were isolated from plant-derived endophytic species of the genus Talaromyces [9,10,11]. The fungal strain used in the present work was isolated from the inner tissue of the fresh collected marine red alga Laurencia okamurai .…”

Section: Introductionmentioning

confidence: 99%

Two New Diphenylketones and a New Xanthone from Talaromyces islandicus EN-501, an Endophytic Fungus Derived from the Marine Red Alga Laurencia okamurai

Liu

et al. 2016

Marine Drugs

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Two new diphenylketones (1 and 2), a new xanthone (3), and a known xanthone analogue (4) were isolated and identified from Talaromyces islandicus EN-501, an endophytic fungus obtained from the fresh collected marine red alga Laurencia okamurai. Their structures were elucidated on the basis of NMR spectroscopic and X-ray crystallographic analysis. The joint isolation of benzophenones and xanthones from the same fungal strain supports the biogenesis of xanthones via a benzophenone intermediate. It is worth mentioning that xanthones 3 and 4 have a methyl group at C-6 and C-2, respectively, which is uncommon compared with typical xanthones usually having a methyl group at C-8. Compounds 1–4 exhibited potent antioxidative activities against DPPH (1,1-diphenyl-2-picrylhydrazyl) and ABTS (2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonate) radicals with IC50 values ranging from 0.58 to 6.92 μg/mL, which are stronger than that of the positive controls BHT (butylated hydroxytoluene) and ascorbic acid. Compounds 1, 3, and 4 also showed inhibitory activities against several pathogenic bacteria.

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