A new fluorescent boronic acid sensor based on carbazole for glucose sensing <i>via</i> aggregation-induced emission

Oloub, Mandana; Hosseinzadeh, Rahman; Tajbakhsh, Mahmood; Mohadjerani, Maryam

doi:10.1039/d2ra04110c

Cited by 5 publications

(3 citation statements)

References 37 publications

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“…Because of the high binding affinity of phenylboronic acid for cis -diols, various fluorophores with appended boronic acids have been designed for direct carbohydrate binding [ 36 ]. In this regard, molecules with vibration-induced luminescence (VIE) [ 37 ] and aggregation-induced luminescence (AIE) [ 38 ] properties were explored for glucose detection. Galan et al synthesized a VIE-based fluorescence receptor (Fig.…”

Section: Boronic Acid-based Sensing Platformmentioning

confidence: 99%

Sensitive and specific detection of saccharide species based on fluorescence: update from 2016

Huang

Han

et al. 2023

Anal Bioanal Chem

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Increasing evidence supports the critical role of saccharides in various pathophysiological steps of tumor progression, where they regulate tumor proliferation, invasion, hematogenic metastasis, and angiogenesis. The identification and recognition of these saccharides provide a solid foundation for the development of targeted drug preparations, which are however not fully understood due to their complex and similar structures. In order to achieve fluorescence sensing of saccharides, extensive research has been conducted to design molecular probes and nanoparticles made of different materials. This paper aims to provide in-depth discussion of three main topics that cover the current status of the carbohydrate sensing based on the fluorescence sensing mechanism, including a phenylboronic acid-based sensing platform, non-boronic acid entities, as well as an enzyme-based sensing platform. It also highlights efforts made to understand the recognition mechanisms and improve the sensing properties of these systems. Finally, we present the challenge of achieving high selectivity and sensitivity recognition of saccharides, and suggest possible future avenues for exploration. Graphical Abstract

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Section: Boronic Acid-based Sensing Platformmentioning

confidence: 99%

Sensitive and specific detection of saccharide species based on fluorescence: update from 2016

Huang

Han

et al. 2023

Anal Bioanal Chem

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“…Extended efforts have been devoted to the fabrication of devices for effective real-time monitoring of glucose levels and point of care analysis. [4] In medical analysis, the necessity for real-time monitoring of urea levels rivals that of glucose monitoring. Tracking and maintaining the appropriate levels of these two analytes has become increasingly significant in medical treatment and diagnosis.…”

Section: Introductionmentioning

confidence: 99%

“…Disrupted regulation of glucose levels leads to Diabetes mellitus , which requires on‐going treatment and monitoring as it can lead to severe complications. Extended efforts have been devoted to the fabrication of devices for effective real‐time monitoring of glucose levels and point of care analysis [4] …”

Section: Introductionmentioning

confidence: 99%

Discriminative detection of glucose and urea with a composite polymer nanofiber based matrix

Apetrei,

Guven,

Camurlu

2024

ChemistrySelect

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Detection and quantification of glucose and urea are fundamental in medical analysis, real‐time monitoring, and point of care analysis. However, such analyses generally require sophisticated instrumentation and specialized personnel. Furthermore, discriminative detection of multiple analytes is often necessary for treatment and diagnosis. To address this challenge, this study describes a proof‐of‐concept for discriminative sensitive amperometric detection of both analytes. This was achieved by the fabrication of a polymer‐MWCNTs composite nanofiber matrix upon which glucose oxidase (GOD) and urease were co‐immobilized to allow detection of the corresponding substrates (glucose and urea). The (PAN(−MWCNTs)/Urease‐GOD) biosensor showed good performance in: (i) glucose biosensing with sensitivity of 31±5 μAmM−2cm−2 within an extended linear range (0.1–5.0 mM) and a limit of detection of 3.7 μM, and (ii) urea detection at very low concentration (4–30 and 30–90 μM) with sensitivity up to 350±19 μAmM−2cm−2 and very low LOD (0.1 μM). The analogous mono‐enzyme platform for urea detection (PAN(−MWCNTs)/Urease) showed very similar performance as the bi‐enzyme sensor, suggesting little to no influence of co‐immobilization on Urease activity, thus confirming that the two catalytic processes are independent of each other. The biosensors exhibited high accuracy in the detection of both analytes (at normal and pathological levels) in human serum, thus proving that the biosensor described herein can have practical applications in healthcare and remote patient monitoring.

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The effect of –CF3 substitution position on the aggregation-induced emission, solvatofluorochromism and mechanofluorochromism properties of the conjugated 9-butyl-9H-carbazole phenylacrylonitrile derivatives

Suresh

Ramachandran

Krishnan

et al. 2023

Journal of Photochemistry and Photobiology A: Chemistry

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A new fluorescent boronic acid sensor based on carbazole for glucose sensing via aggregation-induced emission

Abstract: An amphiphilic chemosensor for a highly selective ratiometric fluorescent response toward glucose via AIE is introduced. High binding constant (K = 2.3 × 106 M−1) and low detection limit (5.9 × 10−7 M) make it an efficient chemosensor for glucose.

Cited by 5 publications

References 37 publications

Sensitive and specific detection of saccharide species based on fluorescence: update from 2016

Sensitive and specific detection of saccharide species based on fluorescence: update from 2016

Discriminative detection of glucose and urea with a composite polymer nanofiber based matrix

The effect of –CF3 substitution position on the aggregation-induced emission, solvatofluorochromism and mechanofluorochromism properties of the conjugated 9-butyl-9H-carbazole phenylacrylonitrile derivatives

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