A new flavanenol with urease-inhibition activity isolated from roots of manna plant camelthorn (Alhagi maurorum)

Laghari, Abdul Hafeez; Memon, Shahabuddin; Nelofar, Aisha; Khan, Khalid Mohammed; Yasmin, Arfa; Syed, Muhammad Noman; Aman, Afsheen

doi:10.1016/j.molstruc.2009.11.039

Cited by 28 publications

(16 citation statements)

References 11 publications

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“…[9] Here, in the present study, we have investigated the biosynthesis of AuNPs by A. maurorum flower extract. This proves to be a newer novel green chemistry-based approach for synthesizing biocompatible, stable, cost-effective, and eco-friendly AuNPs under different reaction conditions.…”

Section: Original Articlementioning

confidence: 98%

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Anita

2017

AJP

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Aim: The aim of this study is to synthesize gold nanoparticles (AuNPs) from flower extract of Alhagi maurorum and aqueous gold chloride through a simple green route. Materials and Methods: AuNPs were synthesized by the reaction mixture containing freshly prepared flower aqueous extract and HAuCl 4 solution. The reduction of Au 3+ ions to AuNPs was monitored at different time intervals (0-180 min), at different concentration of chloroauric acid (0.1-2.0 mM), and at varying content of flower extract (1.0-25.0 ml). Characterization and storage stability of synthesized AuNPs were also noticed in this study. Results and Discussion: Optimization studies showed that 0.5 mM of chloroauric acid and lower amount (5.0 ml) of flower extract in 1:5 ratio facilitated maximum synthesis of AuNPs at an incubation period of 20 min. Transmission electron microscopic study revealed a size range of 12-24 nm and crystalline nature of biosynthesized AuNPs. The possible involvement of biomolecules in the formation of AuNPs was confirmed by Fourier transform infrared spectroscopy (FTIR) study. Stability of synthesized AuNPs showed only some microaggregates in the reaction mixture after 120 days which indicates the formation of highly stable AuNPs by a novel, simple, non-toxic, and eco-friendly route. Conclusions: Flower extract of A. maurorum could be used as an efficient green material for the rapid and consistent synthesis of AuNPs and their use as an antimicrobial agent in drug delivery system and in pharmaceutical and medical industry for the human welfare.

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Section: Original Articlementioning

confidence: 98%

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Anita

2017

AJP

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“…vegetables, fruits, flowers, roots, stems and herbs. 7,8,9 Present studies have shown that flavonoids from Coreopsis tinctoria Nutt. have a significant amounts of bioactive components.…”

Section: Introductionmentioning

confidence: 93%

Optimization of Total Flavonoids Extraction from Coreopsis tinctoria Nutt. by Response Surface Methodology

Liu¹

2014

Kem. Ind.

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Response surface methodology (RSM) was applied to predict optimum conditions for extraction of flavonoid from Coreopsis tinctoria Nutt. A central composite design (CCD) was used to monitor the effect of extraction temperature, extraction time, and water-to-material ratio on yield of total flavonoids. The optimal extraction conditions were obtained as water-to-material ratio of 55 ml g −1 , extraction temperature of 80 °C and extraction time of 70 minutes. Under these conditions, the average total flavonoids yield, according to the mass of raw material, was 9.0 ± 0.6 %, which corresponds to the predicted value of 8.9 %. Thus, the extraction method was applied successfully to extract total flavonoids from C. tinctoria.

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“…Laghari et al purified a flavanenol 3,4‐dimethyl‐5,6,7,8,2′,3′,5′,6′‐octamethoxyflavan‐3‐en‐4′‐ol ( 54 ) (Fig. ) from ethyl acetate fraction of the roots of Alhagi maurorum .…”

Section: Pure Compounds Isolated From Plants With Anti‐urease Activitymentioning

confidence: 99%

Plant‐Derived Urease Inhibitors as Alternative Chemotherapeutic Agents

Hassan

Žemlička²

2016

Archiv der Pharmazie

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Inhibition of the metalloenzyme urease has important pharmacologic applications in the field of antiulcer and antigastric cancer agents. Urease is involved in many serious infections caused by Helicobacter pylori in the gastric tract as well as by Proteus and related species in the urinary tract. Although numerous studies have described several novel urease inhibitors (UIs) used for the treatment of gastric and urinary infections, all these compounds have exhibited severe side effects, toxicity, and instability. Therefore, to overcome such problems, it is necessary to search for new sources of UIs, such as natural products, that provide reduced side effects, low toxicity, greater stability, and bioavailability. As limited studies have been conducted on plant-derived UIs, this paper aims to highlight and summarize the most promising compounds isolated and identified from plants, such as terpenoids, phenolic compounds, alkaloids, and other substances with inhibitory activities against plant and bacterial ureases; these are in vitro and in vivo studies with an emphasis on structure-activity relationship studies and types of inhibition that show high and promising levels of anti-urease activity. This will aid medicinal chemists in the design and synthesis of novel and pharmacologically potent UIs useful for the development of antiulcer drugs.

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A new flavanenol with urease-inhibition activity isolated from roots of manna plant camelthorn (Alhagi maurorum)

Cited by 28 publications

References 11 publications

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Optimization of Total Flavonoids Extraction from Coreopsis tinctoria Nutt. by Response Surface Methodology

Plant‐Derived Urease Inhibitors as Alternative Chemotherapeutic Agents

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