A new family of folate-decorated and carbon nanotube-mediated drug delivery system: Synthesis and drug delivery response

Huang, Haifeng; Yuan, Quan; Shah, J.S.; Misra, R.D.K.

doi:10.1016/j.addr.2011.04.001

Cited by 170 publications

(89 citation statements)

References 38 publications

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“…Anthracyclines, especially DNR and DOX have been widely investigated using various spectroscopic methods, e.g. Raman spectroscopy [24,25], Resonance Raman (RR) [26][27][28], Surface Enhanced Raman Spectroscopy (SERS) [29][30][31][32], UV-Vis absorption [26,33] and FT-IR absorption spectroscopy [24,34,35]. The visible absorption spectra of DOX and DNR are, however, almost identical, having a maximum of absorption near to 480-490 nm.…”

Section: Introductionmentioning

confidence: 99%

Spectroscopic studies of anthracyclines: Structural characterization and in vitro tracking

Szafraniec

Majzner

Farhane³

et al. 2016

Spectrochimica Acta Part A: Molecular and Biomolecular Spectros

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A broad spectroscopic characterization, using ultraviolet-visible (UV-vis) and Fourier transform infrared absorption as well as Raman scattering, of two commonly used anthracyclines antibiotics (DOX) daunorubicin (DNR), their epimers (EDOX, EDNR) and ten selected analogs is presented. The paper serves as a comprehensive spectral library of UV-vis, IR and Raman spectra of anthracyclines in the solid state and in solution. The particular advantage of Raman spectroscopy for the measurement and analysis of individual antibiotics is demonstrated. Raman spectroscopy can be used to monitor the in vitro uptake and distribution of the drug in cells, using both 488 nm and 785 nm as source wavelengths, with submicrometer spatial resolution, although the cellular accumulation of the drug is different in each case. The high information content of Raman spectra allows studies of the drug-cell interactions, and so the method seems very suitable for monitoring drug uptake and mechanisms of interaction with cellular compartments at the subcellular level.

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Section: Introductionmentioning

confidence: 99%

Spectroscopic studies of anthracyclines: Structural characterization and in vitro tracking

Szafraniec

Majzner

Farhane³

et al. 2016

Spectrochimica Acta Part A: Molecular and Biomolecular Spectros

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show abstract

“…[12][13][14][15][16][17][18][19] Liu et al 20 proposed a new drug delivery system using polyethylene glycol (PEG)-functionalized SWCNTs attached to DOX. Water-soluble SWCNTs by PEG functionalization exhibited an extremely high loading efficiency of ~400%.…”

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confidence: 99%

Carbon nanotubes as cancer therapeutic carriers and mediators

Son¹,

Hong²,

Lee³

2016

IJN

216

106

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Carbon nanotubes (CNTs) have received increasing attention in biomedical fields because of their unique structures and properties, including high aspect ratios, large surface areas, rich surface chemical functionalities, and size stability on the nanoscale. Particularly, they are attractive as carriers and mediators for cancer therapy. Through appropriate functionalization, CNTs have been used as nanocarriers for anticancer drugs including doxorubicin, camptothecin, carboplatin, cisplatin, paclitaxel, Pt(II), and Pt(IV), and genes including plasmid DNA, small-interfering RNA, oligonucleotides, and RNA/DNA aptamers. CNTs can also deliver proteins and immunotherapy components. Using combinations of light energy, they have also been applied as mediators for photothermal therapy and photodynamic therapy to directly destroy cancer cells without severely damaging normal tissue. If limitations such as a long-term cytotoxicity in the body, lack of size uniformity during the synthetic process, loading deviations for drug–CNT complexes, and release controllability at the target point are overcome, CNTs will become one of the strongest tools that are available for various other biomedical fields as well as for cancer therapy.

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“…MCN can also protect the encapsulated agents from degradation during delivery (Hartmann et al, 2005;Huang et al, 2011;Ramanathan et al, 2005;Wan et al, 2016;Zhao et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Evaluating the ameliorative potential of plant flavonoids and their nanocomposites in bleomycin induced idiopathic pulmonary fibrosis

Kar¹,

Biswas²,

Banerjee³

2016

Biomed Res Ther

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Abstract-Introduction: Pulmonary Fibrosis can severely disrupt lung function. The cause of Idiopathic Pulmonary Fibrosis (IPF) is still unclear. The treatment currently available for IPF provides minimal benefits. Bleomycin is used in research to induce experimental pulmonary fibrosis in animals. Plant flavonoids such as fisetin and curcumin are known for their anti-inflammatory properties. The aim was to demonstrate the path of physiological changes in bleomycin induced IPF and to further evaluate the reversal and ameliorative potentials of some plant flavonoids and their nanocomposites. Bleomycin administration is known to damage the lung epithelial cells resulting in lower cell numbers. Methods: The Balb/c mice were used as models for bleo-induced IPF. Inflammation was measured by the generation of ROS, RONI, and histological assessment. Cell proliferation was measured by MTS assay and CFU assay. Results: Our colony-forming assay in BALF also demonstrated a reduction (1.65 fold) in colony-forming unit after bleomycin administration. The number of colonies increased upon treatment with fisetin(1.20 fold) and curcumin (1.13 fold) respectively. MTT proliferation assay demonstrated a significant increase in the number of viable cells upon treatment with curcumin (1.42 fold) and fisetin (1.74 fold) respectively, in the lung. The NBT assay demonstrated a significant effect of curcumin in BALF, lung and peripheral blood. A significant effect of fisetin was observed in BALF and peripheral blood. Conclusion: These findings were also supported by the histological analyses of the lung samples. Curcumin showed highest potential for the treatment of IPF and fisetin showed its ameliorative effect.

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A new family of folate-decorated and carbon nanotube-mediated drug delivery system: Synthesis and drug delivery response

Cited by 170 publications

References 38 publications

Spectroscopic studies of anthracyclines: Structural characterization and in vitro tracking

Spectroscopic studies of anthracyclines: Structural characterization and in vitro tracking

Carbon nanotubes as cancer therapeutic carriers and mediators

Evaluating the ameliorative potential of plant flavonoids and their nanocomposites in bleomycin induced idiopathic pulmonary fibrosis

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