A new experimental model: the vascular pedicle cutaneous flap over the dorsal aspect (flank and hip) of the rat

Syed, Shamsuddin A.; Tasaki, Yukihiro; Fujii, Tohru; Hirano, Akiyoshi; Kobayashi, Kazuo

doi:10.1016/0007-1226(92)90109-b

Cited by 23 publications

(11 citation statements)

References 5 publications

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“…Three different axial-pattern flaps on the rat dorsum have recently been described [9 -11]. These dorsal skin flaps were harvested from the flank and lateral aspect of the hip [9], the thoracic region of the dorsum [10], and the middorsum [11], based on the iliolumber [9], lateral thoracic [11], or 10th posterior intercostal [11] vessels, respectively. Because these models could not be used as multiple vascular territory skin flaps with predictable necrosis, they have not been adopted extensively in experimental flap research.…”

Section: Introductionmentioning

confidence: 99%

An Extended Dorsal Island Skin Flap with Multiple Vascular Territories in the Rat: A New Skin Flap Model

Yang

Morris

1999

Journal of Surgical Research

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Section: Introductionmentioning

confidence: 99%

An Extended Dorsal Island Skin Flap with Multiple Vascular Territories in the Rat: A New Skin Flap Model

Yang

Morris

1999

Journal of Surgical Research

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“…Syed et al [3] described this flap as the skin area supplied by the iliac branch of iliolumbar artery. Its borders were from the back of 12th rib to the proximal part of the tail medially and the axillary line laterally.…”

Section: Flank Flapmentioning

confidence: 99%

Experimental Rat Flap Models

Serin¹,

Bayrami̇çli̇²

2018

Issues in Flap Surgery

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Experimental flap surgery aims to increase our understanding of flap physiology and to test new surgical techniques to increase flap viability. Many experimental flap models have been described with the advancement of flap surgery and research. Most commonly used experimental flaps used in rats, including dorsal skin, flank, epigastric, oblique groin, pectoral, latissimus dorsi, rectus abdominis and fibula flaps, will be described.

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“…The survival of the skin island was evaluated on postoperative day 7 by gross inspection of the flap color compared with normal skin. 21 Microangiography. Microangiography was applied to delineate the vascularization of the osteomuscle flap in two animals on postoperative day 7.…”

Section: Assessment Of Flap Viabilitymentioning

confidence: 99%

“…Higher survival rates of the cellular elements, minimal bone resorption, and faster and better callus formation were demonstrated in the vascularized bone grafts. 21 In free bone graft transfers, most of the bone cells except those immediately subjacent to the periosteum perished, and the dead bone acted as a scaffolding for the ingrowth of new cells. Because of the poorly vascularized tissue bed often found in the reconstruction of composite defects, reconstruction with a flap consisting of bone gives more pleasing results than with a soft-tissue flap over a bone graft.…”

Section: Composite Flaps Containing Vascularized Bone Have Some Advanmentioning

confidence: 99%

New experimantal composite flap model in rats: Gluteus maximus‐tensor fascia lata osteomuscle flap

et al. 2003

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Experimental animal models need to be developed for studies of composite flaps that have often recently been used for defects of both bone and soft tissues. A consistent anatomy, simple surgical technique, and reliable blood flow are essential for the success of experimental flap studies. Here we propose a gluteus maximus-tensor fascia lata osteomuscle flap in rats as a model of these qualities. Gluteus maximus and tensor fascia lata muscles and the adjacent iliac bone segment were combined as a lateral circumflex femoral artery-based flap. To test the reliability of this composite flap, three types of composite tissues were harvested and replaced: osteomusculocutaneous flap, osteomuscle flap, and osteomuscle composite graft. The osteomusculocutaneous flap was elevated by including a skin island over the gluteal region. The osteomuscle graft was formed by deliberately dividing the vascular pedicle of the osteomuscle flap. Direct observation revealed complete necrosis of the skin islands in all osteomusculocutaneous flaps. Microangiography of the flap demonstrated that both muscles and the attached bone were supplied by the pedicle. Dye studies with nitro blue tetrazolium (NBT) and India ink demonstrated dye uptake in both muscle and bone components in osteomuscle flaps. Histological examinations also demonstrated the viability of both tissues only in the flap group. Bone scintigraphy performed in flaps on postoperative day 7 demonstrated radionuclide uptake, confirming perfusion of the bony segment. The gluteus maximus-tensor fascia lata osteomuscle flap is a reliable and simple model for composite flap studies that offers the following advantages: 1) it is a new composite flap which includes bone, 2) it can be dissected easily with the naked eye, without using the microscope, 3) it has a long pedicle for flap displacement, and 4) it is a small animal model.

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A new experimental model: the vascular pedicle cutaneous flap over the dorsal aspect (flank and hip) of the rat

Cited by 23 publications

References 5 publications

An Extended Dorsal Island Skin Flap with Multiple Vascular Territories in the Rat: A New Skin Flap Model

An Extended Dorsal Island Skin Flap with Multiple Vascular Territories in the Rat: A New Skin Flap Model

Experimental Rat Flap Models

New experimantal composite flap model in rats: Gluteus maximus‐tensor fascia lata osteomuscle flap

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