A new epoxidic ganoderic acid and other phytoconstituents from Ganoderma lucidum

Joseph, Soniamol; Janardhanan, K. K.; George, Varughese; Baby, Sabulal

doi:10.1016/j.phytol.2011.08.011

Cited by 11 publications

(4 citation statements)

References 15 publications

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“…Lanostanol was formed through a MVA pathway as an 8,9-ene skeleton; nevertheless, the double bond was transformed to an epoxy group due to the presence of oxygenase's [135]. 8α,9α-Epoxy-3,7,11,15,23-pentaoxo-5α-lanosta-26-oic acid (253) (Figure 6) was isolated from the chloroform extract of the fruiting bodies of G. lucidum and exhibited good antifungal activity against Candida albicans in disc diffusion assay (100 µg/disc) [240]. 7(8),9(11)-diene-triterpenoids ∆ 7(8),9 (11) -triterpenoids are also a series of lanostane-type triterpenoids which were frequently isolated from Ganoderma (Table 2).…”

Section: 9-epoxy-triterpenoidsmentioning

confidence: 99%

A Review of Ganoderma Triterpenoids and Their Bioactivities

et al. 2022

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For centuries, Ganoderma has been used as a traditional medicine in Asian countries to prevent and treat various diseases. Numerous publications are stating that Ganoderma species have a variety of beneficial medicinal properties, and investigations on different metabolic regulations of Ganoderma species, extracts or isolated compounds have been performed both in vitro and in vivo. However, it has frequently been questioned whether Ganoderma is simply a dietary supplement for health or just a useful “medication” for restorative purposes. More than 600 chemical compounds including alkaloids, meroterpenoids, nucleobases, nucleosides, polysaccharides, proteins, steroids and triterpenes were extracted and identified from Ganoderma, with triterpenes serving as the primary components. In recent years, Ganoderma triterpenes and other small molecular constituents have aroused the interest of chemists and pharmacologists. Meanwhile, considering the significance of the triterpene constituents in the development of new drugs, this review describes 495 compounds from 25 Ganoderma species published between 1984 and 2022, commenting on their source, biosynthetic pathway, identification, biological activities and biosynthesis, together with applications of advanced analytical techniques to the characterization of Ganoderma triterpenoids.

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Section: 9-epoxy-triterpenoidsmentioning

confidence: 99%

A Review of Ganoderma Triterpenoids and Their Bioactivities

et al. 2022

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“…Stellasterol was also isolated from fruiting bodies of Ganoderma lucidum as pentadecanoate ester ( 9 ), which at a dose 100 mg/kg bw demonstrated moderate anti-inflammatory activity (60% inhibition) in carrageenan-induced paw edema [ 93 ].…”

Section: Sterolsmentioning

confidence: 99%

Structure and Biological Activity of Ergostane-Type Steroids from Fungi

2022

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Mushrooms are known not only for their taste but also for beneficial effects on health attributed to plethora of constituents. All mushrooms belong to the kingdom of fungi, which also includes yeasts and molds. Each year, hundreds of new metabolites of the main fungal sterol, ergosterol, are isolated from fungal sources. As a rule, further testing is carried out for their biological effects, and many of the isolated compounds exhibit one or another activity. This study aims to review recent literature (mainly over the past 10 years, selected older works are discussed for consistency purposes) on the structures and bioactivities of fungal metabolites of ergosterol. The review is not exhaustive in its coverage of structures found in fungi. Rather, it focuses solely on discussing compounds that have shown some biological activity with potential pharmacological utility.

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“…A pesar de que no fue posible separar los Ácidos Ganodéricos presentes en el extracto, se corroboró su presencia, tomando el espectro UV-Vis del pico a 12,45 min y comparándolo con aquellos reportados en la bibliografía [32]. Con la ayuda del software del detector UV-Vis con arreglo de diodos, se pudo determinar también, el solapamiento de los picos en la señal.…”

Section: Análisis Cromatográficounclassified

Ácidos ganodéricos en Ganoderma sp, Ganoderma lucidum y en su sustrato agotado

Ayala

Bravo

Espinosa

2020

Biotecnol. sector agropecuario agroind.

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Los hongos del Género Ganoderma son reconocidos mundialmente por sus propiedades medicinales y su mercado nacional e internacional crece continuamente. Con el objetivo de indagar acerca del potencial comercial de nuestra diversidad fúngica, se determinaron los contenidos de compuestos bio-activos, conocidos como Ácidos Ganodéricos (A.G.), a partir de tres fuentes del hongo. De los cuerpos fructíferos de dos variedades de Ganoderma sp y Ganoderma lucidum (silvestre y comercial). La variedad silvestre fue recolectada en el municipio de Quimbaya Quindío, la comercial, certificada, se cultivó sobre residuos agroindustriales de plátano y el sustrato agotado fue obtenido después de la recolección de la variedad comercial. Las tres muestras obtenidas por triplicado, fueron secadas y sometidas a extracción con fluidos supercríticos y por ultrasonido. La concentración de A.G. se determinó por Cromatografía Líquida (HPLC), por el método de normalización de áreas, usando como estándar el Acido Ganodérico A. Los mayores rendimientos de extracción fueron obtenidos por el método de ultrasonido, independientemente de la muestra analizada. El mayor contenido de A.G., fue encontrado en la cepa silvestre (266 µg/g), aproximadamente 30% más que en la variedad comercial, aunque considerablemente menor a estudios internacionales. Es posible concluir que la variedad silvestre tendría potencial para convertirse en una fuente comercial de A.G.

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A new epoxidic ganoderic acid and other phytoconstituents from Ganoderma lucidum

Cited by 11 publications

References 15 publications

A Review of Ganoderma Triterpenoids and Their Bioactivities

A Review of Ganoderma Triterpenoids and Their Bioactivities

Structure and Biological Activity of Ergostane-Type Steroids from Fungi

Ácidos ganodéricos en Ganoderma sp, Ganoderma lucidum y en su sustrato agotado

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