A new entry to the substituted pyrrolo[3,2-c]quinoline derivatives of biological interest by intramolecular heteroannulation of internal imines

Optimization of the Suzuki coupling reaction in the synthesis of 2‐[(2‐substituted)phenyl]pyrrole derivatives

“…Synthesis of pyrrole derivatives having molecular skeletons similar to 1 and 2 has been reported [3][4][5][6][7][8]. However, the synthetic strategy was mostly based on tedious multistep synthetic procedures involving a condensation of the pyrrole ring [3][4][5][6][7][8].…”

“…However, the synthetic strategy was mostly based on tedious multistep synthetic procedures involving a condensation of the pyrrole ring [3][4][5][6][7][8]. Recently, the one-pot synthesis of diverse 2-substituted, 2,3-and 2,5-disubstituted NH-and N-vinylpyrroles through the Trofimov reaction of ketoximes with acetylenes was reported [9].…”

Microwave-assisted multi-step synthesis of novel pyrrolo-[3,2-c]quinoline derivatives

“…1) have been known for several years as one of the most widely used motifs in medicinal chemistry. Several derivatives of such heterocycles possess a wide spectrum of biological activities, including most notably antitumor 5 and hypotensive 6 properties, gastric (H þ /K þ )-ATPase inhibition, [7][8][9] anti-inflammatory activities, 10 and 5-HT 3 agonism [11][12][13] (Fig. 1).…”

Practical one-pot sequential procedure for the preparation of N-arylated 3,4-disubstituted pyrroles from alkenes

“…N-Arylated substituted pyrroles have been found very important applications in pharmaceutical researches [1][2][3][4][5][6][7][8][9][10][11][12][13]. Paal-Knorr pyrrole synthesis offered a classic route for their preparation, but with limitation by using pre-formed 1,4-diketones [8][9][10][11][12][13].…”

“…Paal-Knorr pyrrole synthesis offered a classic route for their preparation, but with limitation by using pre-formed 1,4-diketones [8][9][10][11][12][13]. Recently, many alternative synthetic methods have been developed for this purpose.…”