A New Electrode for Electromyographic Study of Bronchial Smooth Muscle

Akasaka, Kazuaki; Konno, Kunihiko; Ono, Yasuo; Mue, Suetsugu; Abe, Chozo; Kumagai, Mutsumi; Ise, Tadao

doi:10.1620/tjem.117.49

Cited by 5 publications

(6 citation statements)

References 2 publications

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“…airway smooth muscle; bronchial smooth muscle; quick stretch; electrical field stimulation; serum immunoglobulin E THE MECHANISM(S) BY WHICH human airways become hyperreactive to endogenous mediators of anaphylaxis in asthma remains elusive. However, increased responsiveness of airway smooth muscle (ASM) causes augmented narrowing of the conducting airways (9) and increased airway resistance (1). Using bronchoscopically placed extracellular electrodes, Akasaka et al (1) demonstrated that asthmatic subjects have increased phasic electrical activity in their bronchi compared with normal individuals.…”

mentioning

confidence: 99%

Passive sensitization of human airways induces myogenic contractile responses in vitro

Mitchell

Rabe²,

Magnussen³

et al. 1997

Journal of Applied Physiology

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We assessed effects of passive sensitization on human bronchial smooth muscle (BSM) response to mechanical stretching in vitro. Bronchial rings were sham (control) or passively sensitized overnight by using sera from donors demonstrating sensitivity to Dermatophagoides farinae and having immunoglobulin E (IgE) concentrations of 2,600 +/- 200 U/ml. Tissues were fixed isometrically to force transducers to measure responses to electrical field stimulation (EFS) and quick stretch (QS). The myogenic response to QS was normalized to the maximal response to EFS (%EFS). The myogenic response of sensitized BSM was 47.9 +/- 10.9 %EFS to a QS of approximately 6.5% optimal length (Lo); sham-sensitized tissues had a myogenic response of 13.5 +/- 6.4 %EFS (P = 0.012 vs. passively sensitized). A QS of approximately 13% Lo in sensitized BSM caused a response of 82.8 +/- 20.9 %EFS; sham-sensitized tissues developed a response of 38.2 +/- 17.3 %EFS (P = 0.004). BSM incubated with serum from nonallergic donors did not demonstrate increased QS response (4.6 +/- 1.4 %EFS, P = not significant vs. tissue exposed to atopic sera). However, tissues incubated in sera from nonatopic donors supplemented with hapten-specific chimeric IgE (JW8) demonstrated augmented myogenic response to QS of approximately 6.5% Lo (21.9 +/- 6.2 %EFS, P = 0. 027 vs. nonatopic sera alone). We demonstrate that passive sensitization of human BSM preparations causes induction and augmentation of myogenic contractions to QS; this hyperresponsiveness corresponds to the IgE concentration in sensitizing sera.

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mentioning

confidence: 99%

Passive sensitization of human airways induces myogenic contractile responses in vitro

Mitchell

Rabe²,

Magnussen³

et al. 1997

Journal of Applied Physiology

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“…On the other hand, we observed that during asthmatic attack the discharge of the spike potential increased up to 6-14 per sec from sporadic discharge with a long pause during non-attack phase by the new electrode (Akasaka et al 1975a, b) Akasaka (1965) also observed, in the continuous bronchographical study, the reversible change in caliber of the bronchial wall during asthmatic attack. All of these observations can support the resonant mechanism of the bronchial wall per se as a pathogenesis of whistling rale.…”

Section: W Histling Ralementioning

confidence: 66%

Acoustical Studies on Respiratory Sounds in Asthmatic Patients

Akasaka

Konno

Ono

et al. 1975

Tohoku J. Exp. Med.

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“…The electrode to record action potentials from the bronchial smooth muscle was fundamentally the same as described by us in the preceding paper (Akasaka et al 1975).…”

Section: Methodsmentioning

confidence: 99%

“…Action potentials were recorded in the same manner as described in the preceding paper (Akasaka et al 1975). …”

Section: Methodsmentioning

confidence: 99%