A New Drug Delivery System Using Plasma-Irradiated Pharmaceutical Aids. IX. Controlled-Release of Theophylline from Double-Compressed Tablet Composed of Cellulose Derivatives as Wall Material.

Abstract

The rapid release from a double-compressed tablet containing theophylline with the water-soluble polymer, hydroxypropylmethylcellulose (HPMC) or hydroxypropylmethylcellulose phthalate (HPMCP), used as a wall material can be suppressed by argon plasma-irradiation and changed into the sustained-release system due to a decrease in solubility of the outer layer. It was shown that the release profiles can be varied so as to cause theophylline release at different rates, depending on the set of conditions chosen for tablet manufacture and for plasma operation.

Irradiation of Cellulosic Pulps: Understanding Its Impact on Cellulose Oxidation

“…Flow volume (32.07 mL/min) and pressurized nitrogen gas (0.1 MPa) for plasmolysis were applied for 3 and 5 minutes, respectively, to each sample. 25,26 Cellulose Analysis. Labeling.…”

Nature of Mechanoradical Formation of Substituted Celluloses as Studied by Electron Spin Resonance

“…6) We have further undertaken the characterization of the plasma-induced radicals of several other substituted celluloses such as carboxylmethylcellulose (CMC), 2-acetamido-2-deoxycellulose (chitin), and 2-amino-2-deoxycellulose (chitosan) 7) in response to the need for experimental design in a series of studies on novel plasma-assisted drug-delivery system (DDS) preparations. [8][9][10][11][12][13][14][15][16][17][18][19] The substituted celluloses thus far studied are all pharmaceutically important polymers used as pharmaceutical aids and food additives. The study of mechanolysis is of fundamental significance in connection with the manufacture of a wide variety of solid materials in industry.…”

Preparation of Floating Drug Delivery System by Plasma Technique

“…2, and this apparatus is essentially the same as reported earlier. [9][10][11][12][13][14][15][16][17][18][19] The plasma state was generated by the use of radio frequency discharges of inductive coupling with supplied power of 70 and 100 W at 13.56 MHz. Flow volume (50 ml/min) and pressure of argon gas (0.5 Torr (66.7 Pa)) for plasmolysis were controlled by flow meter and changing evacuating speed, respectively.…”

“…Over the years, in a series on preparation of double-compressed (DC) tablets for use in a DDS with plasma techniques, we have reported that novel sustained-and delayedrelease systems can be prepared by plasma-irradiation on the outer layer of DC tablet, [9][10][11][12][13][14][15][16][17][18][19] as well as matrix-type composite powder for sustained-drug release system can be prepared by mechanically-amplified plasma processing. [20][21][22] During the course of such studies on plasma-assisted DDS preparation, we have found that the carbon dioxide was trapped in the tablet when argon plasma was irradiated onto the DC tablet composed of plasma-crosslinkable polymers possessing carboxyl group as an outer layer.…”