A new Drosophila octopamine receptor responds to serotonin

Qi, Yixin; Xu, Gang; Gu, Gui-Xiang; Mao, F.; Yè, Gōngyín; Liu, Weiwei; Huang, Jia

doi:10.1016/j.ibmb.2017.09.010

Cited by 53 publications

(79 citation statements)

References 31 publications

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“…Members of octopamine receptors have been reported from many insects in recent years . So far, there are three families of octopamine receptors, including α 1 ‐adrenergic‐like octopamine receptors (OA1), β‐adrenergic‐like octopamine receptors (OA2), and α 2 ‐adrenergic‐like octopamine receptors (OA3) . Activation of OA1 leads to the elevation of [Ca 2+ ] i and [cAMP] i levels when expressed in HEK‐293 cell line .…”

Section: Resultsmentioning

confidence: 99%

“…A similar alternative splicing phenomenon was also reported in fruit fly. However, besides octopamine and tyramine, serotonin and serotoninergic agonists can also activate the orthologue OA3 receptor from Drosophila . This indicated that orthologue receptors from different insects could have different pharmacological properties.…”

Section: Resultsmentioning

confidence: 99%

“…All of NlOA2 subtypes are assembled in a group that contains β ‐ adrenergic‐like octopamine receptors from Drosophila, Bombyx, Apis, and Chilo . And NlOA3 clustered with CsOA3 and DmOA3, which belongs to α 2 ‐ adrenergic‐like octopamine receptors.…”

Section: Resultsmentioning

confidence: 99%

“…Both of them cause increases of intracellular Ca 2+ concentration, and activation of the short form results in decreased intracellular [cAMP] i . Recent work has shown that activation of both isoforms of OA3 in Drosophila with octopamine, tyramine and serotonin could inhibit cAMP production …”

Section: Introductionmentioning

confidence: 99%

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Molecular features and expression profiles of octopamine receptors in the brown planthopper, Nilaparvata lugens

Huang

et al. 2019

Pest Management Science

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BACKGROUND Octopamine, the invertebrate counterpart of adrenaline and noradrenaline, regulates and modulates many physiological and behavioral processes in insects. It mediates its effects by binding to specific octopamine receptors, which belong to the superfamily of G‐protein coupled receptors (GPCRs). The expression profiles of octopamine receptor genes have been well documented in different developmental stages and multiple tissue types in several different insect orders. However, little work has addressed this issue in Hemiptera. RESULTS In this study, we cloned four octopamine receptor genes from brown planthopper. The deduced amino acid sequences share high identity with other insect homologues and have the characteristic GPCRs domain architecture: seven transmembrane domains. These genes were expressed in all developmental stages and examined tissues. The expression of NlOA2B3 and NlOA3 was relatively higher in egg and first instar nymph stage than in other stages and other receptor genes. All of these receptor genes were more highly expressed in brain than other tissues. CONCLUSION The identification of octopamine receptor genes in this study will provide a foundation for investigating the diverse roles played by NlOARs and for exploring specific target sites for chemicals that control agricultural pests. © 2019 Society of Chemical Industry

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Molecular features and expression profiles of octopamine receptors in the brown planthopper, Nilaparvata lugens

Huang

et al. 2019

Pest Management Science

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“…Whether the OAMB receptor is a true OCT receptor or a mixed OCT/TYR receptor has been a matter of some recent conjecture (El-Kholy et al, 2015). Very recently, a putative novel receptor with homology to a 2 -adrenoceptors was reported in Drosophila, coupled to G i -mediated inhibition of adenylyl cyclase, and activated by both OCT and TYR (Qi et al, 2017).…”

Section: Octopamine Receptorsmentioning

confidence: 99%

Trace Amines and Their Receptors

Gainetdinov¹,

Hoener²,

Berry³

2018

Pharmacol Rev

254

246

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Biogenic amine biosynthetic and transduction genes in the endoparasitoid wasp Pteromalus puparum (Hymenoptera: Pteromalidae)

Wang²,

et al. 2019

Arch Insect Biochem Physiol

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Biogenic amines (BAs), such as octopamine, tyramine, dopamine, serotonin, and acetylcholine regulate various behaviors and physiological functions in insects. Here, we identified seven genes encoding BA biosynthetic enzymes and 16 genes encoding BA G protein‐coupled receptors in the genome of the endoparasitoid wasp, Pteromalus puparum. We compared the genes with their orthologs in its host Pieris rapae and the related ectoparasitic wasp Nasonia vitripennis. All the genes show high (>90%) identity to orthologs in N. vitripennis. P. puparum and N. vitripennis have the smallest number of BA receptor genes among the insect species we investigated. We then analyzed the expression profiles of the genes, finding those acting in BA biosynthesis were highly expressed in adults and larvae and those encoding BA receptors are highly expressed in adults than immatures. Octα1R and 5‐HT7 genes were highly expressed in salivary glands, and a high messenger RNA level of 5‐HT1A was found in venom apparatuses. We infer that BA signaling is a fundamental component of the organismal organization, homeostasis and operation in parasitoids, some of the smallest insects.

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A new Drosophila octopamine receptor responds to serotonin

Cited by 53 publications

References 31 publications

Molecular features and expression profiles of octopamine receptors in the brown planthopper, Nilaparvata lugens

Molecular features and expression profiles of octopamine receptors in the brown planthopper, Nilaparvata lugens

Trace Amines and Their Receptors

Biogenic amine biosynthetic and transduction genes in the endoparasitoid wasp Pteromalus puparum (Hymenoptera: Pteromalidae)

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