A new diphenolic metabolite isolated from the marine-derived fungus <i>Aspergillus niger</i> 102

Zhang, Panpan; Song, Shuang; Lang, Jiajia; Jia, Chunxiu; Yan, Sujun; Liu, Lan; Chen, Senhua; Li, Jing

doi:10.1080/10286020.2018.1488830

Cited by 4 publications

(2 citation statements)

References 22 publications

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“…In addition, it was found that the COVID-19 mortality rate in breast cancer patients depends more on comorbidities than prior radiation therapy or current anti-cancer treatment [9]. Currently, breast cancer is the leading (30%) common cancer and the second (23%) cause of cancer death among women, which is considered as a top killer for women [10]. Therefore, these patients need to take additional precautions against the COVID-19 outbreak.…”

Section: Introductionmentioning

confidence: 99%

COVID-19 precautionary behavior among Israeli breast cancer patients

Shinan-Altman

Levkovich

2021

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Objective Cumulative knowledge indicates that cancer patients, among them breast cancer patients, are more susceptible to COVID-19 than individuals without cancer. Therefore, these patients need to take additional precautions against the COVID-19 outbreak. This study aimed to examine factors associated with precautionary behavior among Israeli breast cancer patients during the COVID-19 pandemic. Methods A cross-sectional study was conducted among 151 women with breast cancer. Participants completed measures of knowledge about COVID-19, perceived threat, sense of mastery, social support, precautionary behavior, and socio-demographic questionnaires. A multivariate regression model was calculated with precautionary behavior as the dependent variable. Results The mean of precautionary behavior score was relatively high. Participants perceived their health as relatively good, had relatively high knowledge about COVID-19, and moderate perceived threat. Sense of mastery was relatively moderate and perceived social support was relatively high. In the multivariate regression analysis, after controlling for the background variables, knowledge about COVID-19 (F(2,149) = 8.68, p < 0.001; beta = 0.36) was significantly associated with precautionary behavior. This variable explained 15.4% of the precautionary behavior variance. Conclusion Findings suggest that in order to enhance precautionary behavior among women with breast cancer during a pandemic outbreak, it is recommended to pay attention their knowledge about the virus.

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Section: Introductionmentioning

confidence: 99%

COVID-19 precautionary behavior among Israeli breast cancer patients

Shinan-Altman

Levkovich

2021

Support Care Cancer

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“…The compounds isolated from Aspergillus niger caught a lot of attention because of their chemical diversities and significant biological activity. Fumonisins, naptho‐γ‐pyrones (NGPs), bicoumarins, asperazines and malformins are important secondary metabolites from A. niger , [ 3 ] which displayed significant biological activity including antimicrobial [ 4 ] and antitumour effects. [ 5 ]…”

Section: Introductionmentioning

confidence: 99%

Pyoluteorin induces cell cycle arrest and apoptosis in human triple-negative breast cancer cells MDA-MB-231

Ding

Yang

Zhang

et al. 2020

Journal of Pharmacy and Pharmacology

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Objectives To screen the cytotoxic activity of six secondary metabolites isolated from soil fungus Aspergillus niger. Importantly, to investigate the mechanism that pyoluteorin induced human triple-negative breast cancer MDA-MB-231 cells apoptosis in vitro. Methods The cell viability assay was tested with CTG assay. Cell cycle, apoptosis and intracellular reactive oxygen species (ROS) production assay were tested with flow cytometry. Additionally, intracellular ROS production assay and mitochondrial membrane potential assay were determined with laser scanning confocal microscopy. The expression of apoptosis-related proteins was determined with Western blot. Key findings Pyoluteorin displayed significantly selective cytotoxicity against human triple-negative breast cancer MDA-MB-231 cells (IC 50 = 0.97 µM) with low toxicity against human breast epithelial cell MCF-10A. It was found that pyoluteorin could arrest MDA-MB-231 cells cycle at G 2 /M phase and induce cell apoptosis. Further experiments demonstrated that the apoptosis-inducing effect of pyoluteorin was related to reduction of mitochondrial membrane potential, accumulation of ROS and change of apoptosis-related protein expressions. Conclusion Our studies revealed that pyoluteorin had potent proliferation inhibition against MDA-MB-231 cells through arresting cell cycle at G 2 /M phase and inducing caspase-3-dependent apoptosis by mitochondrial pathway, implying that pyoluteorin may be a potential lead compound for drug discovery of human triple-negative breast cancer.

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