A new diagnostic vestibular evoked response

Dastgheib, Zeinab; Lithgow, Brian; Blakley, Brian W.; Moussavi, Zahra

doi:10.1186/s40463-015-0065-7

Cited by 14 publications

(15 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The trade‐off for utilizing a matched filter within the detection algorithm is that the NEER algorithm will inherently detect FP's even in pure noise. The ratio of real‐detected FPs from a noisy signal is dependent on the signal‐to‐noise ratio 10 . Thus, regardless of whether there is a Scarpa's ganglionectomy or not, the system will detect some FPs even in noise.…”

Section: Discussionmentioning

confidence: 99%

“…The ratio of real-detected FPs from a noisy signal is dependent on the signal-to-noise ratio. 10 Thus, regardless of whether there is a Scarpa's ganglionectomy or not, the system will detect some FPs even in noise.…”

Section: Discussionmentioning

confidence: 99%

“…The second main source of evidence 4 was based on EVestG recordings on four anesthetized guinea pigs with: (1) normal hearing and vestibular function, then (2) following cisplatin‐induced auditory toxicity, and then (3) following both cisplatin auditory and gentamicin vestibular ablation. The FPs were found to be both acoustic and vestibular in origin, that is, vestibuloacoustic; albeit predominately vestibular 2,10 . This finding was not surprising, considering that the recording electrode of EVestG is placed in the ear canal but understanding the nature of FPs also opens the door for possible treatments.…”

Section: Introductionmentioning

confidence: 93%

See 2 more Smart Citations

Verification EVestG recordings are vestibuloacoustic signals

Blakley

Ashiri

Moussavi

et al. 2022

Laryngoscope Investig Oto

Self Cite

View full text Add to dashboard Cite

Introduction: Neural dysfunction is associated with aberrant nerve firing; thus, electrodiagnosis has the potential for objective diagnosis and quantification of neural dysfunction. Electrical stimulation alters nerve firing and may also have treatment potential. This article outlines some findings related to electrodiagnosis and electrical stimulation of the ear. The quasi-synchronous firing of many vestibuloacoustic nerve fibers can produce an extracellular potential defined as a field potential (FP). Electrovestibulography (EVestG) is a method to record vestibuloacoustic signals and detect the associated FPs. A clear picture of the muscle-, EEG-, saccade-related, or other artefactual origins, and the physiologic basis of FPs recorded with EVestG, is evolving. EVestG was applied to demonstrate the effect of electrical stimulation on spontaneous FPs in the ear canal.Methods: Bilateral EVestG recordings were conducted on 14 guinea pigs before and after stimulation with 3-0.5 mA ipsilateral anodal electrical pulses before and after ablation via unilateral Scarpa's ganglionectomy to elucidate the origin of the EVestG recorded spontaneous FPs.Results: Anodal electrical stimulation suppresses the recorded activity. There was a significant reduction of the level of recorded signal observed following anodal stimulation on the ablated but not the intact side. Conclusion:Electrical stimulation of the external auditory canal reduces spontaneous electrical activity in the ear canal, some of which is due to central nervous system activity. The EVestG recorded FPs have a major vestibuloacoustic component.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 93%

See 1 more Smart Citation

Verification EVestG recordings are vestibuloacoustic signals

Blakley

Ashiri

Moussavi

et al. 2022

Laryngoscope Investig Oto

Self Cite

View full text Add to dashboard Cite

show abstract

“…25 In our previous studies, 4,8 we used the same dataset as in, 25 which was recorded at the EVestG Lab of the Alfred Hospital (Melbourne, Australia), for training the classifiers' algorithm. In that study, we investigated many features and extracted the characteristic features that were found statistically significant between the Meniere's and healthy individuals of the training dataset using only one tilt (side tilt), and designed an algorithm for classification of patients with Meniere's disease.…”

Section: Introductionmentioning

confidence: 99%

Application of Vestibular Spontaneous Response as a Diagnostic Aid for Meniere’s Disease

Dastgheib

Lithgow

Blakely³

et al. 2015

Ann Biomed Eng

View full text Add to dashboard Cite

In this paper, we report on a new method for assisting in Meniere's disease diagnosis. An accurate diagnosis of Meniere's is challenging, and requires an expert opinion after observing several clinical assessments and tests over a period of time. Our proposed method is based on the analysis of the spontaneous and driven ear evoked responses recorded using Electrovestibulography (EVestG). We used the EVestG signals of 35 individuals suspected of Meniere's and 26 age-matched healthy controls, out of which data of 14 patients with Meniere's and 16 healthy controls were used for developing the diagnostic algorithm (training set) and the rest for testing. While recording and analyzing the test dataset, the researchers were only aware the patients suffered some dizziness, and were kept blind to the exact diagnoses till the end of study. EVestG field potentials (FPs) and their firing pattern, in response to several whole body tilt stimuli from both left and right ears were extracted. We investigated several features of the extracted FPs in response to each of side, back/forward, rotation, up/down, supine rotation, and supine up/down tilt stimulations, and selected the top five features showing the most significant differences between of the groups of the training set for every tilt. An ad-hoc average voting classifier was designed based on building five single-feature classifiers (using Linear Discriminant analysis) and taking the average of the single-feature classifiers' votes. The results showed the side tilt data were best for the purpose of Meniere's diagnosis; it resulted in 78% and 90% sensitivity and specificity for test dataset, respectively. The second best accuracy was achieved using back/forward tilt. The results and their implications are discussed. Overall, the EVestG side tilt results encourage the use of vestibular response as a non-invasive, robust and quick screening for Meniere's and separating it from other types of dizziness.

show abstract

“…There is evidence that the EVestG responses are vestibuloacoustic and predominantly vestibular [1][2][3][4][5]. EVestG assessment has been applied to the detection of a number of pathologies including Alzheimer's Disease (AD) [5], Parkinson's Disease (PD) [6], Post-Concussion Syndrome (PCS [7][8][9], Vertiginous disorders [10][11][12], Major Depressive Disorder (MDD) [2], non-manic Bipolar Disorder [1] and the separation of Bipolar and MDD [13]. In previous studies we have collected Electrovestibulography recording data from Parkinson's Disease (PD), Alzheimer Disease (AD), Post-Concussion Syndrome (PCS), Major Depression and Bipolar Depression populations as well as a pool of healthy controls (N = 117).…”

Section: Introductionmentioning

confidence: 99%

Effect of Multi-site Variabilities on Electrovestibulography: Environmental and Physical Factors

Lithgow¹,

Moussavi²

2019

Res. Dev. Info. Commun. Tech. J.

Self Cite

View full text Add to dashboard Cite

Background: There are physiological changes in pathologies such as Alzheimer’s Disease (AD) within the lower vestibuloacoustic system, which may be potentially useful when used as neurodegeneration features. We hypothesize two Electrovestibulography feature types (Field Potential (FP) shape and the Firing pattern of detected FP’s) may have utility as Neurodegeneration features. Our long term objective is to use a population of Parkinson’s Disease (PD), AD, Post-Concussion Syndrome (PCS), Bipolar Disorder (BD) and Major Depressive Disorder (MDD) patients together with individual pathology-wise age and gender matched control cohorts to determine the degree to which each of these pathologies varies from controls and in proportion to the level of Neurodegeneration often associated (either temporarily or permanently) with each pathology. However, before such a comparison can be made it is necessary to ensure the various populations recorded across different countries are comparable. This paper determines which populations are comparable. Methods: An initial comparison of AD (with N = 16) and a best matched healthy control population (with specific age/gender/recording site/electrode matched controls) from a pool of 112 controls produced two EVestG features (FP shape and FP firing pattern). These features were examined for their variability with respect to electrode type, age, gender, powerline frequency and environmental factors. Results: Age and gender did not have a significant impact on the features. Powerline and environmental artefacts could be accounted for by filtering; thus, they did not significantly affect the features measured. However, electrode type had a significant effect on the extracted features. Conclusions: For the two EVestG features tested only electrode type had a significant effect on the recordings, and hence the extracted features. Thus, only populations with the same electrode type can be compared.

show abstract

A new diagnostic vestibular evoked response

Cited by 14 publications

References 17 publications

Verification EVestG recordings are vestibuloacoustic signals

Verification EVestG recordings are vestibuloacoustic signals

Application of Vestibular Spontaneous Response as a Diagnostic Aid for Meniere’s Disease

Effect of Multi-site Variabilities on Electrovestibulography: Environmental and Physical Factors

Contact Info

Product

Resources

About