A New Diagnostic Approach to Mucosal Inflammation in Proctocolitis

Anthonisen, P

doi:10.1016/s0140-6736(61)92374-1

Cited by 25 publications

(8 citation statements)

References 8 publications

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“…CYTOLOGY OF THE MUCOSAL SECRETION A specimen of the surface secretion of the area of mucosa being studied was obtained on 52 occasions using the method of Anthonisen and Riis (1961). A circular coverslip, 10 mm.…”

Section: Clinical Materials and Methods Of Investigationmentioning

confidence: 99%

Sigmoidoscopy and cytology in the detection of microscopic disease of the rectal mucosa in ulcerative colitis

Watts¹,

Thompson²,

Goligher³

1966

Gut

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Section: Clinical Materials and Methods Of Investigationmentioning

confidence: 99%

Sigmoidoscopy and cytology in the detection of microscopic disease of the rectal mucosa in ulcerative colitis

Watts¹,

Thompson²,

Goligher³

1966

Gut

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“…A considerable infiltration of eosinophils is seen in the mucosa of the rectum and colon as well as in the luminal inflammatory exudate (Truelove and Richards, 1956;Goldgraber, Kirsner, and Palmer, 1960;Anthonisen and Riis, 1962; Riis and Anthonisen, 1964). Histamine is assumed to play an important part in allergic reactions and it was therefore considered of interest to determine the histamine content of the mucosa in patients with ulcerative colitis.…”

mentioning

confidence: 99%

“…Three parameters have been compared: the mucosal histamine content, the distribution of different cell types in the rectal inflammatory exudate, and the clinical severity of the disease. METHODS CYTOLOGICAL TECHNIQUE Cytological examination of the rectal inflammatory exudate was performed according to the method of Anthonisen and Riis (1961). A proteincoated glass disc fixed on a cork was inserted through a sigmoidoscope and lightly pressed against the mucosa for about one second.…”

mentioning

confidence: 99%

Histamine content of rectal mucosa in ulcerative colitis.

Binder¹,

Hvidberg²

1967

Gut

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“…Soon after the introduction of the imprint method as a differential-diagnostic tool for separating slightly inflammatory from non-inflarnmatory diseases, we described the presence of inflammatory eosinophilia in many patients with ulcerative colitis (1,2).…”

Section: Ilerrmarkmentioning

confidence: 99%

Eosinophilic Granulocytes in the Rectal Mucus of Patients with Ulcerative Colitis and Crohn's Disease of the Ileum and Colon

Anthonisen

Riis

1971

Scandinavian Journal of Gastroenterology

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Anthonisen. P. & Riis, P. 1971. Eosinophilic Granulocytes in the Rectal Mucus of Patients with Ulcerative Colitis and Crohn's Disease of the Ileum and Colon. Scarrd. J . Gusrroerir. 6 , 731-734.The frequent presence of inflammatory eosinophilia in ulcerative colitis, compared with other inflammatory states such as Crohn's disease. has previously been described by us. This investigation is a controlled study of the observation. 359 patients with ulcerative colitis and 36 patients with Crohn's disease of the small and large bowel, both fulfilling the department's diagnostic criteria of the two diseases, were included in the study. Cytological imprints of the rectal mucus by first diagnostic contact were blindly classified according to presence or absence of eosinophilia. Inflammatory cells \\ere present in 351 patients with ulcerative colitis and 26 with Crohn's disease. Eosinophilia was detected in 248 (70%) and 4 (approx. 15Yc) respectively. The difference of proportions is highly significant. The demonstration of cytological eosinophilia in a non-glucocorticoid-treated patient thus makes a diagnosis of ulcerative colitis more likely than one o f Crohn's disease.

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A New Diagnostic Approach to Mucosal Inflammation in Proctocolitis

Cited by 25 publications

References 8 publications

Sigmoidoscopy and cytology in the detection of microscopic disease of the rectal mucosa in ulcerative colitis

Sigmoidoscopy and cytology in the detection of microscopic disease of the rectal mucosa in ulcerative colitis

Histamine content of rectal mucosa in ulcerative colitis.

Eosinophilic Granulocytes in the Rectal Mucus of Patients with Ulcerative Colitis and Crohn's Disease of the Ileum and Colon

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