A new dendrimer series: synthesis, free radical scavenging and protein binding studies

Abstract

Superhydrophobic dendrimers with excellent antioxidant properties, and the ability to bind proteins and enzymes in their functional void spaces.

Non-equilibrium Binding Energy Determined Using Alpha-amylase Catalysed Amylolysis of Gelatinised Starch as a Probable Generalisable Model and Importance

“…The importance of non-equilibrium binding energies is better corroborated or elucidated with examples of researches where binding affinity is regularly mentioned apart from the formation of encounter complex formation preceding enzyme-substrate complex formation used as model in this research. The webderimers (poly(amidoamine)) that are believed to possess binding affinity for nanoparticles for drug and gene encapsulation for drug transport and delivery [42] and cerium oxide nanoparticles (CNPs) for therapeutic applications for the cure of neurological oxidative stresses [23] requires information about the binding energy with both target and unintended target organ, tissue, cell etc. The 1st tier dendrimers with a common 1, 3,5-benzenetricarbonyl trichloride/trimesoyl chloride (TMC) core [42] can only exhibit its scavenging activity against reactive oxygen species (free radicals which triggers carcinogenesis, cardiovascular disease etc) in an effective manner if they possess strong binding affinity (energy) that remains essentially irreversible.…”