A New Cytotoxic Stilbenoid from Arundina graminifo

Meng, Chunyang; Niu, De‐Yun; Li, Yin-Ke; Zeng, Bin; Ye, Yanqing; Du, Gang; Hu, Qiu‐Fen

doi:10.14233/ajchem.2014.16082

Cited by 9 publications

(2 citation statements)

References 5 publications

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“…Arundina graminifolia (D. Don) Hochr., a species widely distributed in subtropical Asia and known as bai-yang-jie in Chinese, has a long history of use as one of the major drugs in a formula “BaoGan Capusle” with the efficacy of heat clearing and detoxifying, dispersing blood and relieving pain, reducing inflammation and promoting urination and so on [1]. Previous phytochemical investigation focusing on the chloroform and ethyl acetate exacts of A. graminifolia had resulted in the separation of stilbenoids [2,3,4], phenols [5,6,7], flavonoids [8,9] and other ketones [3,10,11]. However, the works on the polar parts of the plant are few.…”

Section: Introductionmentioning

confidence: 99%

HPLC-ESI-MSn Identification and NMR Characterization of Glucosyloxybenzyl 2R-Benzylmalate Deriva-Tives from Arundina Graminifolia and Their Anti-Liver Fibrotic Effects In Vitro

et al. 2019

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Four new glucosyloxybenzyl 2R-benzylmalate derivatives, named Arundinoside H (2), I (5), J (6), K (8) as well as four known compounds Arundinoside D (1), G (3), F (4), E (7) were isolated and characterized by a combination of chemical and spectroscopic methods, including HR-ESI-MS, 1D and 2D NMR experiments. Besides, 24 unreported compounds were inferred from ESI-MSn data. The anti-liver fibrotic activities of the isolates were determined as proliferation inhibition of lipopolysaccharide (LPS)-induced activation of rat hepatic stellate cells (HSC-T6). The result suggested Arundinosides D, H, F, I and K showed moderate inhibitory effects in vitro.

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Section: Introductionmentioning

confidence: 99%

HPLC-ESI-MSn Identification and NMR Characterization of Glucosyloxybenzyl 2R-Benzylmalate Deriva-Tives from Arundina Graminifolia and Their Anti-Liver Fibrotic Effects In Vitro

et al. 2019

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“…In Bangladesh, it used to cure rheumatism (Hossain, 2009 ). Previous studies have reported stilbenoids as the major secondary metabolites in bamboo orchid, revealing the structural diversity of phenanthrenes (Liu et al, 2005 ), diphenylethylenes (Hu et al, 2013b ; Li et al, 2013a ; Gao et al, 2014 ; Meng et al, 2014 ; Yang et al, 2014 ), bibenzyls (Majumder and Ghosal, 1993 ; Du et al, 2014 ), and other phenolic compounds (Gao et al, 2012 ; Hu et al, 2013a ; Lidan et al, 2013 ; Li et al, 2013b ; Niu et al, 2013 ). Bibenzyls are effective antitumor agents due to their antioxidant and cell-protective properties (Gong, 2003 ; Zhang et al, 2007 ; Barbosa et al, 2009 ; Li et al, 2010 ; Su, 2011 ; Cai et al, 2015a ).…”

Section: Introductionmentioning

confidence: 99%

The Transcriptome Profiling of Flavonoids and Bibenzyls Reveals Medicinal Importance of Rare Orchid Arundina graminifolia

et al. 2022

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Orchids are very important flowering plants that spend long juvenile phases before flowering. Along with aesthetic importance, they are rich sources of medicinal components. However, their long reproductive cycle is the major hurdle to study the medicinal efficacy. Arundina graminifolia is a rare orchid that grows fast, unlike other orchids, and this characteristic makes it an ideal plant to study the medicinal enrichment of orchids. Therefore, this study presents the identification of important medicinal components in various parts of A. graminifolia. Transcriptome analysis was performed for five stages (FD1–FD5) of flower development and four tissue types (mature flower, silique, root, and leaf) to ascertain genetic regulators of flavonoids and bibenzyls. Most of the genes showed the highest expression in roots as compared with other tissues. Weighted gene coexpression network analysis (WGCNA) was performed to identify the coexpression modules and the candidate genes involving biosynthesis pathways of these chemicals. MEyellow module contained the highly coexpressed genes. Moreover, the concentrations of phenylpropanoid, bibenzyls, and flavone were ascertained through high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). Phenylpropanoid and bibenzyl were comparatively high in the leaf, while flavone showed a high concentration in the stem. The selected candidate genes [bibenzyl biosynthesis (BIBSY212), CYP84A1, CYP73A4, 4CLL7, UGT88B1, UGT73C3, anthocyanin synthase (ANS), phenylalanine ammonia-lyase (PAL), flavanone synthase FLS, and CHS8] were validated through quantitative real-time PCR (qRT-PCR). Most of these genes showed high expression in leaf and root as compared with other tissue. Therefore, the presence of bibenzyls and flavonoids in different parts of A. graminifolia and their molecular regulators can provide a quick source to decipher the medicinal efficacy of orchids.

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Two New Stilbenes from the Whole Plant of Arundina graminifolia and Their Anti-SARS-CoV-2 Activity

Li,

Zhang,

Zhao

et al. 2024

Chem Nat Compd

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A New Cytotoxic Stilbenoid from Arundina graminifo

Cited by 9 publications

References 5 publications

HPLC-ESI-MSn Identification and NMR Characterization of Glucosyloxybenzyl 2R-Benzylmalate Deriva-Tives from Arundina Graminifolia and Their Anti-Liver Fibrotic Effects In Vitro

HPLC-ESI-MSn Identification and NMR Characterization of Glucosyloxybenzyl 2R-Benzylmalate Deriva-Tives from Arundina Graminifolia and Their Anti-Liver Fibrotic Effects In Vitro

The Transcriptome Profiling of Flavonoids and Bibenzyls Reveals Medicinal Importance of Rare Orchid Arundina graminifolia

Two New Stilbenes from the Whole Plant of Arundina graminifolia and Their Anti-SARS-CoV-2 Activity

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