A new cytotoxic plumbagin derivative from roots of <i>Diospyros undulata</i>

Suchaichit, Nattawut; Kanokmedhakul, Kwanjai; Boottanun, Patcharaporn; Sermswan, Rasana W.; Moosophon, Panawan; Kanokmedhakul, Somdej

doi:10.1080/14786419.2019.1630120

Cited by 8 publications

(3 citation statements)

References 18 publications

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“…Plumbagin has a variety of biological properties, including antioxidant, antiviral, antibacterial, antimalarial, and antiinflammatory activities (24,34). Some studies have shown that plumbagin has cytoxocity against various cancer cell lines including breast cancer, lung cancer, cervical cancer, leukemia, hepatocellular carcinoma, and oral cancer (34,35), but its adverse effects were extremely low (19,24,(36)(37)(38). For this reason, it has attracted increased attention and interest from researchers.…”

Section: Discussionmentioning

confidence: 99%

Establishment of a Jaw Fibrosarcoma Patient-Derived Xenograft and Evaluation of the Tumor Suppression Efficacy of Plumbagin Against Jaw Fibrosarcoma

Yong

Jiang

et al. 2020

Front. Oncol.

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Background: Head and neck fibrosarcoma is a rare malignant tumor, accounting for about 1% of all head and neck tumors. It can also occur in the jaw bone, for which surgical resection is the main treatment but the recurrence rate is high and the prognosis is usually poor. Due to the lack of models mimicking the biological characteristics of the tumor, there is little progress in the research of the pathogenesis and treatment of fibrosarcoma. Therefore, there is an urgent need to explore a high-fidelity model that can reflect the biological characteristics of fibrosarcoma for the sake of improving the therapeutic outcome and prognosis, and preventing recurrence. Patient-derived xenografts (PDX) may more accurately reflect the human disease, and is an attractive platform to study disease biology and develop treatments and biomarkers. In this study we describe the establishment of jaw fibrosarcoma PDX models and compare PDX tumors to those of human origin. Methods: Tumor biopsies from a patient with jaw fibrosarcoma were implanted in immunodeficient mice. Primary and PDX tumors were characterized extensively by histology, immunohistochemistry and humanized identification. Based on the finding of our previous preliminary research that plumbagin had an anti-tumor effect against head and neck cancer, we used this model in the present study to evaluate the anti-tumor effect of plumbagin on jaw fibrosarcoma. Results: The established PDX model maintained the histological and immunohistochemical characteristics of the primary tumor. Plumbagin significantly inhibited the tumor growth in the jaw fibrosarcoma PDX model. Conclusion: We successfully established a PDX model of jaw fibrosarcoma and demonstrated that this PDX model preserved the important molecular characteristics of the human primary tumor, thus providing a powerful tool for treatment research and new drug development of jaw fibrosarcoma. In addition, plumbagin was found to have an inhibitory effect on the growth of PDX modeled jaw fibrosarcoma, which provides a preliminary research basis for its clinical application.

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Section: Discussionmentioning

confidence: 99%

Establishment of a Jaw Fibrosarcoma Patient-Derived Xenograft and Evaluation of the Tumor Suppression Efficacy of Plumbagin Against Jaw Fibrosarcoma

Yong

Jiang

et al. 2020

Front. Oncol.

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“…Therefore, it can meet the advantages of multi-target therapy. [27] In addition to anticancer activity, plumbagin also has antimicrobial activity, which will be described in detail in the following section.…”

Section: Natural 14-nq Analogsmentioning

confidence: 99%

“…It can produce anticancer activity through apoptosis, autophagy, cell cycle arrest, antiangiogenesis, anti‐invasion, antimetastasis pathway, and other mechanisms. Therefore, it can meet the advantages of multi‐target therapy [27] . In addition to anticancer activity, plumbagin also has antimicrobial activity, which will be described in detail in the following section.…”

Section: Introductionmentioning

confidence: 99%

1,4‐Naphthoquinone Analogs and Their Application as Antibacterial Agents

2022

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Antimicrobial resistance threatens the effective prevention and treatment of an ever‐increasing range of infections caused by different types of bacteria. Addressing antibacterial resistance and protecting human health requires multi‐sectoral, long‐acting, and professional administration. Sustainable investment in the R&D of antimicrobial drugs is one of the critical strategies for solving the current problem. Specifically, the development of novel effective drug candidates with a unique mode of action is essential for overcoming antibacterial resistance. 1,4‐Naphthoquinone is a quinone derivative from naphthalene, one of the most important subclasses of quinone. 1,4‐Naphthoquinones have been studied as potential candidates against various diseases, including cancer and malaria, and are a promising new compound that can treat bacterial infections. This review focuses on 1,4‐naphthoquinone analogs for their activity against bacteria.

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