A NEW CYTOTOXIC DOLABELLANE FROM THE INDONESIAN SOFT CORAL &lt;i&gt;Anthelia&lt;/i&gt; sp.

Murni, Anggia; Hanif, Novriyandi; Tanaka, Junichi

doi:10.22146/ijc.21279

Cited by 4 publications

(14 citation statements)

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“…Therefore, the current primary issues in marine conservation, such as the loss of biodiversity through over-exploitation and habitat degradation, can be overcome. Additional information can be found in the Supplementary Materials [95,96,97,98,99,100,101,102,103,104,105,106,107,108,109,110,111,112,113,114,115,116,117,118,119,120,121,122,123,124,125,126,127,128,129,130,131,132,133,134,135,136,137,138,139,140,141,142,143,144,145,146,147,148,149,150,151,152,153,154,…”

Section: Discussionmentioning

confidence: 99%

Marine Natural Products from Indonesian Waters

et al. 2019

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Natural products are primal and have been a driver in the evolution of organic chemistry and ultimately in science. The chemical structures obtained from marine organisms are diverse, reflecting biodiversity of genes, species and ecosystems. Biodiversity is an extraordinary feature of life and provides benefits to humanity while promoting the importance of environment conservation. This review covers the literature on marine natural products (MNPs) discovered in Indonesian waters published from January 1970 to December 2017, and includes 732 original MNPs, 4 structures isolated for the first time but known to be synthetic entities, 34 structural revisions, 9 artifacts, and 4 proposed MNPs. Indonesian MNPs were found in 270 papers from 94 species, 106 genera, 64 families, 32 orders, 14 classes, 10 phyla, and 5 kingdoms. The emphasis is placed on the structures of organic molecules (original and revised), relevant biological activities, structure elucidation, chemical ecology aspects, biosynthesis, and bioorganic studies. Through the synthesis of past and future data, huge and partly undescribed biodiversity of marine tropical invertebrates and their importance for crucial societal benefits should greatly be appreciated.

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Section: Discussionmentioning

confidence: 99%

Marine Natural Products from Indonesian Waters

et al. 2019

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“…In another chemical investigation, one new dolabellane ( 119 ) and two known diterpenoids (stolonidiol ( 120 ) and clavinflol B ( 121 )) (Figure 15) were isolated from the coral Anthelia sp. Among them, compound 119 exhibited cytotoxicity against NBT-T2 cells at 10 μg/mL (31.25 µM), while known compounds 120 and 121 showed stronger cytotoxicity at 1.0 and 0.5 μg/mL (2.98 and 1.34 µM), respectively [108]. Chao et al [109] isolated three new steroidal carboxylic acids, paraminabic acids A–C, from the coral Paraminabea acronocephala .…”

Section: Bioactive Compounds From Coralmentioning

confidence: 99%

Coral and Coral-Associated Microorganisms: A Prolific Source of Potential Bioactive Natural Products

et al. 2019

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Marine invertebrates and their associated microorganisms are rich sources of bioactive compounds. Among them, coral and its associated microorganisms are promising providers of marine bioactive compounds. The present review provides an overview of bioactive compounds that are produced by corals and coral-associated microorganisms, covering the literature from 2010 to March 2019. Accordingly, 245 natural products that possess a wide range of potent bioactivities, such as anti-inflammatory, cytotoxic, antimicrobial, antivirus, and antifouling activities, among others, are described in this review.

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“…Stolonidiol showed cytotoxicity at 1 g/mL and was identified from its 1 H NMR spectrum and specific rotation. Further chromatographic separation resulted in the isolation of the known clavinflol B [18] and a dolabellane [3], and a new minor constituent 1, whose structure ( Figure 1) is the subject of this note. hydroxyl groups.…”

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“…Most of them lack physical defense and therefore have been known to develop chemical defense [1]. The metabolites within the soft corals have been extensively studied resulting in the identification of a diverse array of structurally unique and biologically active terpenoids including eunicellin [2], dolabellane [3], cembrane [4], casbane [5],…”

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“…In our continuing interest in new bioactive molecules from marine organisms [3], an Indonesian soft coral, Anthelia sp., collected at Sunda Strait, Indonesia, was examined. As a lipophilic extract of a specimen of the soft coral showed significant cytotoxicity at 1 g/mL against NBT-T2 cells, the extract was separated to give stolonidiol [17] as one of its major constituents.…”

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A New Trinor-guaiane Sesquiterpene from an Indonesian Soft Coral Anthelia sp

Hanif

Murni

Yamauchi

et al. 2015

Natural Product Communications

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A new trinor-guaiane sesquiterpene has been isolated from an Indonesian soft coral Anthelia sp. The planar structure, possessing an octahydroazulene skeleton, and relative stereochemistry were established by analyzing 1D and 2D NMR data, including NOE experiments. Its absolute stereochemistry was elucidated to be 1S, 4S, 7R, and 10R by comparing observed and calculated optical rotation values. The new compound showed weak cytotoxicity against NBT-T2 cells.

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A NEW CYTOTOXIC DOLABELLANE FROM THE INDONESIAN SOFT CORAL <i>Anthelia</i> sp.

Abstract: One new dolabellane (1) and two known diterpenoids stolonidiol (2)

Cited by 4 publications

References 9 publications

Marine Natural Products from Indonesian Waters

Marine Natural Products from Indonesian Waters

Coral and Coral-Associated Microorganisms: A Prolific Source of Potential Bioactive Natural Products

A New Trinor-guaiane Sesquiterpene from an Indonesian Soft Coral Anthelia sp

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