A New Cyclopentylidene and Other Chemical Constituents from Malaysian Crotalaria pallida

Fadzil, Siti Rabeah; Yap, Ann-Chee; Choo, Yeun‐Mun

doi:10.17576/jsm-2017-4609-29

Cited by 4 publications

(1 citation statement)

References 13 publications

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“…The addition of methanol to F1 of the CC of the butanolic extract yielded a white solid which was analyzed by the NMR technique. The obtained 1 H and 13 C NMR spectra of the solid (Figures S1 and S2) indicated clearly the fatty material nature of this solid, as the observed resonances were in agreement with the literature data [18]. In order to determine the molecular mass of the components of this fatty material, we analyzed it using the GC-MS technique.…”

Section: Fatty Acid Mixturesupporting

confidence: 83%

New Constituents from the Leaves of Date Palm (Phoenix dactylifera L.) of Saudi Origin

et al. 2021

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The phytochemical analysis of the butanolic extract from the leaves of date palm of Saudi origin resulted in the isolation of three major constituents, oleanolic acid (1), vanillyl alcohol (2), and β-sitosterol-3-O-β-d-glucoside (3), which had not been isolated from this plant or previously reported. Together, compounds 1 and 2 account for 1.0% of the butanol extract, which represents 0.4% of the mass of the dried leaves. The isolation of other known compounds for this plant such as fatty acids, lutein, and sucrose was also achieved in this study. The characterization and identification of the isolated compounds were conducted on the basis of Fourier-transform infrared spectroscopy (FTIR), 1H and 13C nuclear magnetic resonance (NMR), liquid chromatography–mass spectrometry (LC–MS), and gas chromatography–mass spectrometry (GC–MS) analyses. The findings of the current study will definitely increase the knowledge about the contribution of the constituents of this plant to its well-known nutrition, corrosion inhibition, and antimicrobial properties.

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Section: Fatty Acid Mixturesupporting

confidence: 83%

New Constituents from the Leaves of Date Palm (Phoenix dactylifera L.) of Saudi Origin

et al. 2021

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Establishment of quality parameters for fruits of Crotalaria pallida Aiton. through microscopy and phytochemical studies

Bolleddu

Narasimhaji

Venkatesh

et al. 2022

Vegetos

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Compounds isolated from hexane fraction of Alternanthera brasiliensis show synergistic activity against methicillin resistant Staphylococcus aureus

Adesanya

Sonibare

Ajaiyeoba

et al. 2021

Physical Sciences Reviews

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Methicillin resistant Staphylococcus aureus (MRSA) has been classified as a “serious threat” by the centre for Disease Control, USA. Alternanthera brasiliensis plant, usually found on wasteland, belongs to the family Amaranthaceae. It is traditionally used for wound healing and has shown antimicrobial effect. Yet, this plant has not been fully explored for its antibacterial activity. Hence, this study evaluated isolated compounds from this plant for its activity against MRSA infections. The leaves extracts and fractions were prepared and concentrated in vacuo using a rotatory evaporator. Isolated compounds were obtained through vacuum liquid chromatographic (VLC) techniques and structurally elucidated with various spectroscopic techniques. Anti-MRSA assay of the fraction and compounds were evaluated by agar-well diffusion and broth-dilution methods while checkerboard assay was used to determine the fractional inhibitory concentration index (FICi). The Gas Chromatography-Mass Spectrometry (GCMS) and High Performance Liquid Chromatography (HPLC) analysis revealed fatty acid and carboxylic acid components like hexadecanoic acid, bis (2-ethylhexyl) phthalate and Fettsäure. The compounds AbHD1 and AbHD5 were identified as hexadecanoic acid and di (ethylhexyl) phthalate. Anti-MRSA assay shows that A. brasiliensis hexane fraction (AbHF) and the compounds had zones of inhibitions (Zi) ranging from 7.3 ± 0.5 to 17.5 ± 0.5 mm with minimum inhibitory concentrations (MIC) between 1.22 × 10−5 – 2.5 mg/mL. Synergistic effects were observed between AbHF and erythromycin, AbHF and ampicillin and AbHF and ciprofloxacin with FICi 0.208–0.375 in K1St4 strain while amoxicillin revealed antagonistic effects against M91 strain (4.67). Similarly, hexadecanoic acid and di (ethylhexyl) phthalate showed synergistic behaviour only with ampicillin against K1St4 while the rest were antagonistic. The study revealed that hexadecanoic acid and di (ethylhexyl) phthalate isolated from A. brasiliensis showed synergistic activity in variations against MRSA isolate and strains.

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A New Cyclopentylidene and Other Chemical Constituents from Malaysian Crotalaria pallida

Cited by 4 publications

References 13 publications

New Constituents from the Leaves of Date Palm (Phoenix dactylifera L.) of Saudi Origin

New Constituents from the Leaves of Date Palm (Phoenix dactylifera L.) of Saudi Origin

Establishment of quality parameters for fruits of Crotalaria pallida Aiton. through microscopy and phytochemical studies

Compounds isolated from hexane fraction of Alternanthera brasiliensis show synergistic activity against methicillin resistant Staphylococcus aureus

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