A new custom made bioceramic implant for the repair of large and complex craniofacial bone defects

Brie, Joël; Chartier, Thierry; Chaput, C.; Delage, Cyrille; Pradeau, Benjamin; Caire, François; Boncœur, Marie-Paule; Moreau, Jean-Jacques

doi:10.1016/j.jcms.2012.11.005

Cited by 105 publications

(84 citation statements)

References 30 publications

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“…Brie et al (2013) used SLA to directly fabricate an HA-resin structure from image data with a mixture of HA powder and a photosensitive resin, and then removed the resin by heating to obtain the final 3D porous HA scaffold. Furthermore, they implanted the scaffolds into bone defect sites of the skull of eight patients.…”

Section: Stereolithographymentioning

confidence: 99%

Rapid prototyping technology and its application in bone tissue engineering

Yuan

Zhou

Chen

2017

J. Zhejiang Univ. Sci. B

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Bone defects arising from a variety of reasons cannot be treated effectively without bone tissue reconstruction. Autografts and allografts have been used in clinical application for some time, but they have disadvantages. With the inherent drawback in the precision and reproducibility of conventional scaffold fabrication techniques, the results of bone surgery may not be ideal. This is despite the introduction of bone tissue engineering which provides a powerful approach for bone repair. Rapid prototyping technologies have emerged as an alternative and have been widely used in bone tissue engineering, enhancing bone tissue regeneration in terms of mechanical strength, pore geometry, and bioactive factors, and overcoming some of the disadvantages of conventional technologies. This review focuses on the basic principles and characteristics of various fabrication technologies, such as stereolithography, selective laser sintering, and fused deposition modeling, and reviews the application of rapid prototyping techniques to scaffolds for bone tissue engineering. In the near future, the use of scaffolds for bone tissue engineering prepared by rapid prototyping technology might be an effective therapeutic strategy for bone defects.

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Section: Stereolithographymentioning

confidence: 99%

Rapid prototyping technology and its application in bone tissue engineering

Yuan

Zhou

Chen

2017

J. Zhejiang Univ. Sci. B

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“…Bone grows epitaxially onto solid HA or into the margins of adequately porous HA. 41, 42 HA, hydrolyzed in situ , is approximately one order of magnitude more brittle than calvarial bone 43 and exhibits approximately 60% of the compressive strength of PMMA (much less than 60% under tension or bending). 44-46 Self-setting CaP paste is commonly troweled into large cranial defects over a titanium mesh to provide additional stiffness 1, 4 or pre-operatively prepared via the use of skull models.…”

Section: Advances In Alloplastic Bone Substitutes For Cranial Repairmentioning

confidence: 99%

“…Attention has recently turned to stereolithography to render large format ceramic cranial implants. 42 A French group, led by Moreau, has generated ceramic graft implants via an AM technique in which polymer is used as a binder during 3-D printing and then sintered away. Their results indicated the potential to use ceramics for large scale defect filling.…”

Section: Advances In Pre-operative Cranial Implant Fabricationmentioning

confidence: 99%

The Recent Revolution in the Design and Manufacture of Cranial Implants

et al. 2015

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Large format (i.e., > 25 cm2) cranioplasty is a challenging procedure not only from a cosmesis standpoint, but also in terms of ensuring that the patient's brain will be well-protected from direct trauma. Until recently, when a patient's own cranial flap was unavailable, these goals were unattainable. Recent advances in implant Computer Aided Design and 3-D printing are leveraging other advances in regenerative medicine. It is now possible to 3-D-print patient-specific implants from a variety of polymer, ceramic, or metal components. A skull template may be used to design the external shape of an implant that will become well integrated in the skull, while also providing beneficial distribution of mechanical force distribution in the event of trauma. Furthermore, an internal pore geometry can be utilized to facilitate the seeding of banked allograft cells. Implants may be cultured in a bioreactor along with recombinant growth factors to produce implants coated with bone progenitor cells and extracellular matrix that appear to the body as a graft, albeit a tissue-engineered graft. The growth factors would be left behind in the bioreactor and the graft would resorb as new host bone invades the space and is remodeled into strong bone. As we describe in this review, such advancements will lead to optimal replacement of cranial defects that are both patient-specific and regenerative.

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“…Currently, they can be used in some applications in reconstructive medicine. Although numerous different materials, such as polyethylene (PE), polymethylmethacrylate (PMMA) and polyetheretherketone (PEEK) and techniques, have been and are under investigation, there is not yet the perfect solution for bone reconstruction because large number of infections relate to autologous bone flaps and implants of various materials [9][10][11][12]. Paradoxically, when the metals are radiologically considered too dense materials, polymers of pf PE, PMMA and PEEK are having disadvantage of being radiolucent, which means that that the material cannot be seen either by conventional X-rays, CTs or MRI images [11].…”

Section: Introductionmentioning

confidence: 99%

“…Bulk ceramic biomaterials of hydroxyapatite (HA) and tricalciumphosphate (TCP) have also been tested as cranial implants [12]. Brittleness of the ceramic materials especially when the material has been processed to porous form is a limiting factor for the clinical use of ceramic materials.…”

Section: Introductionmentioning

confidence: 99%

Bioactive glass-containing cranial implants: an overview

Vallittu

2017

J Mater Sci

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Although metals have successfully been used as implants for decades, devices made out of metals do not meet all clinical requirements. For example, metal objects may interfere with some medical imaging systems (computer tomography, magnetic resonance imaging), while their stiffness also differs from natural bone and may cause stress-shielding and over-loading of bone. There has been a lot of development in the field of composite biomaterial research, which has focused to a large extent on biodegradable composites. This overview article reviews the rationale of using glass fiber-reinforced composite-bioactive glass (FRC-BG) in cranial implants. For this overview, published scientific articles with the search term ''bioactive glass cranial implant'' were collected for having basis to introduce a novel design of composite implant, which contains bioactive glass. Additional scientific information was based on articles in the fields of chemistry, engineering sciences and dentistry. Published articles of the material properties, biocompatibility and possibility to add bioactive glass to the FRC-BG implants alongside with the clinical experience as far suggest that there is a clinical need for bioactive nonmetallic implants. In the FRC-BG implants, biostable glass fibers are responsible for the load-bearing capacity of the implant, while the dissolution of the bioactive glass particles supports osteogenesis and vascularization and provides antimicrobial properties for the implant. Material combination of FRC-BG has been used clinically in cranioplasty and cranio-maxillo-facial implants, and they have been investigated also as oral and orthopedic implants. Material combination of FRC-BG has successfully been introduced to be a potential implant material in cranial surgery.

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A new custom made bioceramic implant for the repair of large and complex craniofacial bone defects

Cited by 105 publications

References 30 publications

Rapid prototyping technology and its application in bone tissue engineering

Rapid prototyping technology and its application in bone tissue engineering

The Recent Revolution in the Design and Manufacture of Cranial Implants

Bioactive glass-containing cranial implants: an overview

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