A New Cubitane Diterpenoid from the Soft Coral Sinularia crassa

Cheng, Chun-Wen; Lin, Yun‐Sheng; Wen, Zhi‐Hong; Su, Jui‐Hsin

doi:10.3390/molecules170910072

Cited by 9 publications

(2 citation statements)

References 12 publications

(20 reference statements)

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“…In contrast, the related cubitane crassalone A 1014 (Sinularia crassa, Taitung County, Taiwan) exhibited no cytotoxicity towards a panel of tumour cell lines. 784 Two separate studies of Cespitularia sp. (Zamami Is., Okinawa) afforded the mildly cytotoxic alcyonolide-type diterpenes 1015-1023.…”

Section: Cnidariansmentioning

confidence: 99%

Marine natural products

et al. 2014

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This review covers the literature published in 2012 for marine natural products, with 1035 citations (673 for the period January to December 2012) referring to compounds isolated from marine microorganisms and phytoplankton, green, brown and red algae, sponges, cnidarians, bryozoans, molluscs, tunicates, echinoderms, mangroves and other intertidal plants and microorganisms. The emphasis is on new compounds (1241 for 2012), together with the relevant biological activities, source organisms and country of origin. Biosynthetic studies, first syntheses, and syntheses that lead to the revision of structures or stereochemistries, have been included.

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Section: Cnidariansmentioning

confidence: 99%

Marine natural products

et al. 2014

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“…The prior studies demonstrated that the cubitanoids originating from marine organisms were elaborated as a minor group in certain species, such as gorgonian corals, Eunicea calyculata [ 3 , 4 ] and E. laciniata [ 20 ], and soft corals, Sinularia triangula [ 21 , 22 ] and S. crassa [ 23 ]. Our present study discovered new cubitanoids from the S. nanolobata, collected off the coast of the eastern region of Taiwan.…”

Section: Discussionmentioning

confidence: 99%

Cubitanoids and Cembranoids from the Soft Coral Sinularia nanolobata

Chao

Huang

et al. 2016

Marine Drugs

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Two new cubitanoids, nanoculones A and B (1 and 2), and three new cembranoids, nanolobols A–C (3–5), as well as six known compounds, calyculone I (6), sinulariuol A (7), sinulariols C, D, H, and J (8–11), were isolated from the soft coral Sinularia nanolobata, collected off the coast of the eastern region of Taiwan. Their structures were elucidated on the basis of extensive spectroscopic analysis. Cytotoxicity of compounds 1–11 was evaluated. The nitric oxide (NO) inhibitory activity of selected compounds was further measured by assay of lipopolysaccharide (LPS)-stimulated NO production in activated RAW264.7 cells. The results showed that none of 1–11 exhibited cytotoxicity against the tested cancer cell lines, whereas compound 8 was found to significantly reduce NO production.

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Sinucrassins A—K, Casbane‐type Diterpenoids from the South China Sea Soft Coral Sinularia crassa

Liu

Wang

et al. 2021

Chin. J. Chem.

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Main observation and conclusion A detailed chemical study on the Hainan soft coral Sinularia crass has resulted in the isolation and characterization of eleven casbane‐type diterpenoids, named sinucrassins A—K (1—11), along with six known related ones (12—17). Their structures were elucidated by extensive spectroscopic analyses and comparison with the reported data. The absolute configurations of new compounds were determined by the X‐ray diffraction analysis and computer‐assisted structural elucidation including 13C NMR data calculation and time‐dependent density functional theory/electronic circular dichroism calculation.

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A New Cubitane Diterpenoid from the Soft Coral Sinularia crassa

Cited by 9 publications

References 12 publications

Marine natural products

Marine natural products

Cubitanoids and Cembranoids from the Soft Coral Sinularia nanolobata

Sinucrassins A—K, Casbane‐type Diterpenoids from the South China Sea Soft Coral Sinularia crassa

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