A New Criterion for Anti-tumor Activity of Tissue Extracts Using Crocker Sarcoma No. 180 in Mice.

Abstract

The amount of aspirin required to ameliorate the glycosuria of the rat is very large. and there is no reason to expect that this drug would be of any therapeutic value in clinical diabetes.Aspirin ~7 a s administered to 7 mildl!. diabetic rats which were force-fed a medium carbohydrate diet. The dose was 30. 80. and 160 mg of the drug per day. A marked amelioration of the glycosuria together with a gain in weight was noted in each rat. U-hen the drug was withdrawn, there was exacerbation of the glycosuria to significantly higher levels than were noted during the preinjection period, and there was an accompanj.ing loss of weight.Sumttzary. C roc ke r S a r c on1 a N 0..4ddenduin. Since this manuscript was submitted for publication a review (Gross, 31. and L. A. Greenberg, Hillhouse Press, Kew Haven, Conn., 1948. pp 108-9) of the effects of salicylates upon carbohydrate metabolism has been noted. Salicylates were shown to have an ameliorating effect upon diabetes mellitus in man as early as 1875, but large and frequently toxic amounts were required and the use of salicylates for this purpose has long since been discontinued. The nature of the action of salicylates upon carbohydrate metabolism remains as an interesting problem.