A new coumarin from the fruits of<b><i>Coutarea hexandra</i></b>

Olmedo, Dionisio A.; Rodriguez, Nelson J.; Vásquez, Yelkaira; Solı́s, Pablo; López-Pérez, Jose Luis; Feliciano, Arturo San; Gupta, Mahabir P.

doi:10.1080/14786410701371116

Cited by 8 publications

(4 citation statements)

References 12 publications

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“…23,24-Dihydrocucurbitacin F and 23,24-dihydro-25-acetylcucurbitacin F have been isolated from the ethanolic extract of Coutarea hexandra fruits. Both compounds have shown moderate cytotoxic activity against MCF-7 cells (44). Another cucurbitacin-derived compound, 23,24-dihyderocucurbitacin B, isolated from the roots of Trichosanthes kirilowli , possesses anticancer activity in a dose- and time-dependent manner against human breast cancer cell lines including Bcap37 and MCF-7.…”

Section: Triterpenoids and Breast Cancermentioning

confidence: 99%

Triterpenoids as potential agents for the chemoprevention and therapy of breast cancer

Bishayee

Ahmed²,

Brankov³

et al. 2011

Front Biosci

289

180

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Breast cancer remains a major cause of death in the United States as well as the rest of the world. In view of the limited treatment options for patients with advanced breast cancer, preventive and novel therapeutic approaches play an important role in combating this disease. The plant-derived triterpenoids, commonly used for medicinal purposes in many Asian countries, posses various pharmacological properties. A large number of triterpenoids are known to exhibit cytotoxicity against a variety of tumor cells as well as anticancer efficacy in preclinical animal models. Numerous triterpenoids have been synthesized by structural modification of natural compounds. Some of these analogs are considered to be the most potent antiinflammatory and anticarcinogenic triterpenoids known. This review examines the potential role of natural triterpenoids and their derivatives in the chemoprevention and treatment of mammary tumors. Both in vitro and in vivo effects of these agents and related molecular mechanisms are presented. Potential challenges and future directions involved in the advancement of these promising compounds in the prevention and therapy of human breast cancer are also identified.

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Section: Triterpenoids and Breast Cancermentioning

confidence: 99%

Triterpenoids as potential agents for the chemoprevention and therapy of breast cancer

Bishayee

Ahmed²,

Brankov³

et al. 2011

Front Biosci

289

180

View full text Add to dashboard Cite

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“…Coutarea hexandra , from the Rubiaceae family, has been used traditionally in the treatment of malaria, inflammation, and diabetes. Olmedo et al performed, with cucurbitacins isolated from the ethanolic extract (80%) of this plant, sulphorhodamine B assay in the following cancer cell lines: breast (MCF-7), lung (H-460) and central nervous system (SF-268), observing moderate cytotoxicity [ 15 ]. Wu et al isolated some cucurbitacins from Begonia nantoensis (Begoniaceae family) such as cucurbitacin B, dihydrocucurbitacin B, cucurbitacin E, dihydrocucurbitacin E, and cucurbitacin I and evaluated their cytotoxicity.…”

Section: Cucurbitacins: Origin Traditional Uses and Therapeutic Poten...mentioning

confidence: 99%

“…Cucurbitacin B isolated from Trichosanthes cucumerina (snake gourd) is the greatest source of cucurbitacins, which ensued the attention of scientists because of its several anticancer mechanisms [ 14 , 15 ]. There are numerous health benefits displayed by the entire Cucurbitaceae family, each vegetable or fruit with a unique effect on human health [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

Cucurbitacins as potential anticancer agents: new insights on molecular mechanisms

et al. 2022

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Since ancient times, plants have been an extensive reservoir of bioactive compounds with therapeutic interest for new drug development and clinical application. Cucurbitacins are a compelling example of these drug leads, primarily present in the plant kingdom, especially in the Cucurbitaceae family. However, these natural compounds are also known in several genera within other plant families. Beyond the Cucurbitaceae family, they are also present in other plant families, as well as in some fungi and one shell-less marine mollusc. Despite the natural abundance of cucurbitacins in different natural species, their obtaining and isolation is limited, as a result, an increase in their chemical synthesis has been developed by researchers. Data on cucurbitacins and their anticancer activities were collected from databases such as PubMed/MedLine, TRIP database, Web of Science, Google Scholar, and ScienceDirect and the information was arranged sequentially for a better understanding of the antitumor potential. The results of the studies showed that cucurbitacins have significant biological activities, such as anti-inflammatory, antioxidant, antimalarial, antimicrobial, hepatoprotective and antitumor potential. In conclusion, there are several studies, both in vitro and in vivo reporting this important anticancer/chemopreventive potential; hence a comprehensive review on this topic is recommended for future clinical research.

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“…Coutarea hexandra, a Brazilian native plant found in the Atlantic rainforest [27], exhibits a range of therapeutic properties, e.g., suppressive activity on inflammatory responses, anti-nociceptive and anti-cancer actions [28,29], including potent antioxidant activity [30]. Based on these positive aspects associated with the therapeutic functions of C. hexandra, and considering its ability in scavenging efficiently the stable radical 2,2-diphenyl-1picrylhydrazyl [30], we aimed to investigate the counteracting action of C. hexandra aqueous stem bark extract (Ch-E) on the systemic effects induced by L. m. muta venom in rats.…”

Section: Introductionmentioning

confidence: 99%

Counteracting Action of Coutarea hexandra (Rubiaceae) Stem Bark Extract on the Systemic Toxicity Induced by Lachesis muta muta (Viperidae: Crotalinae) Venom in Rats

2021

AJBSR

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Purpose: In this work, we investigated the protective action of Coutarea hexandra aqueous stem bark extract (Ch-E), associated with a commercial antivenom or as a stand-alone therapy, on the acute systemic envenomation induced by Lachesis muta muta in rats.Methods: Male Wistar rats (300-350 g) were exposed to L. m. muta venom (1.5 mg/kg -i.m.) and then treated with a polyvalent antivenom (antivenom:venom ratio 1:3 'v/w' -i.p.), Ch-E (100 mg/kg -i.p.) or combining both of these agents. After 120 min envenomation, animals were anesthetized in order to collect blood samples through intracardiac puncture and, subsequently, euthanized for collecting tissue samples; the hematological-biochemical and histopathological analyses were performed through conventional methods.Results: Venom caused pronounced local oedema, necrosis formation and subcutaneous haemorrhage; Ch-E alone or combined with antivenom prevented the occurrence of subcutaneous haemorrhage. Ch-E administered alone or associated with antivenom effectively prevented the increase of serum creatine kinase (CK) and alanine aminotransferase (ALT) release; Ch-E reduced the release of the serum biomarker (CK-MB) for cardiotoxicity only in association with antivenom. Venom caused pronounced inflammatory responses associated with neutrophilia, eosinophilia and monocytosis; Ch-E alone also contributed significantly to reduce the venom-induced leukocytosis mainly due to its suppressive action on neutrophils. Ch-E prevented the venom-induced increase of reticulocytes either alone or in the presence of antivenom; however, no group had erythrocyte alterations.Ch-E produced effective protection against venom-induced hepatic and renal morphological alterations similarly to antivenom action. Conclusion:Ch-E shows to be an important source of biomolecules with therapeutic potential to prevent efficiently a number of systemic disorders caused by L. m. muta venom in rats, e.g., myotoxicity, hepatotoxicity, inflammatory responses.

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A new coumarin from the fruits ofCoutarea hexandra

Cited by 8 publications

References 12 publications

Triterpenoids as potential agents for the chemoprevention and therapy of breast cancer

Triterpenoids as potential agents for the chemoprevention and therapy of breast cancer

Cucurbitacins as potential anticancer agents: new insights on molecular mechanisms

Counteracting Action of Coutarea hexandra (Rubiaceae) Stem Bark Extract on the Systemic Toxicity Induced by Lachesis muta muta (Viperidae: Crotalinae) Venom in Rats

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