A new coumarin from the stem ofAngelica dahurica

Abstract

One new and three known coumarins were isolated from the CHCl3 soluble fraction of Angelica dahurica stem. On the basis of spectral data, the structures of the isolated compounds were determined to be scopoletin, angelol I, angelol H and 6-[(1S), 2(R)-2, 3-dihydroxy-1-methoxy-3-methylbutyl]-7-methoxycoumarin; the latter being isolated for the first time from a plant source.

Research on Chemical Composition and Biological Properties Including Antiquorum Sensing Activity of Angelica pancicii Vandas Aerial Parts and Roots

“…A total of 52 compounds were identified in ME of aerial parts and 53 in ME of the roots (Tables and ). ,− Specified structures are mostly in line with literature on Angelica species and/or the Apiaceae family. Coumarins are represented with 32 compounds found in each analyzed plant part: simple coumarins, coumarin glucoside isoscopoletin β- d -glucopyranoside, furanocoumarins (including furanocoumarin ethers of falcarindiol-japoangelols C and D and furanocoumarin glycoside nodakenin), pyranocoumarins, and bifuranocoumarins dahuribirin D and rivulobirin A.…”

Simultaneous Characterisation of Fifty Coumarins from the Roots ofAngelica dahuricaby Off-line Two-dimensional High-performance Liquid Chromatography Coupled with Electrospray Ionisation Tandem Mass Spectrometry

“…The root of A. dahurica is a well-known herbal medicine used for the treatment of headache, toothache, abscess, furunculosis and acne (Chinese Pharmacopeia Committee, 2010). Given that A. dahurica has diverse and important pharmacological properties, intensive investigations focusing on screening the bioactive constituents from A. dahurica have been carried out leading to the separation and structural elucidation of bioactive components (Baek et al, 2000;Wang et al, 2001;Kwon et al, 2002;Lee et al, 2003;Sarker and Nahar, 2004;Zhao et al, 2007aZhao et al, , 2007bJia et al, 2008;Liu et al, 2011), among which coumarins were the major bioactive constituents, indicating anti-tumour, anti-bacterial, anti-oxidative, antiinflammatory and estrogenic (Kwon et al, 1997;Lin et al, 2002;Thanh et al, 2004;Piao et al, 2006;Hua et al, 2008;Thuong et al, 2010;). However, the conventional methods for screening bioactive constituents and structural elucidation were mainly achieved by column chromatography and spectroscopic techniques, which are laborious and time consuming, and especially the successful preparations of trace components are still challenging.…”

Antioxidant Activity and Irritation Test of Extracts Obtained from Angelica dahurica

“…According to the results of a recent study, extracts of this plant can protect against dexamethasone-induced disorders, and have also been shown to exhibit liver-protective activity, antimicrobial activity (5,6), anti-inflammatory activity, and antimutagenic activity (7). Over twenty coumarins and furanocoumarins, including coumarin, scopoletin, psoralen, xanthotoxin, bergapten, and imperatorin have been isolated from A. dahurica (8)(9)(10).…”