A new convenient method for the synthesis of cardiolipin

Lin, Zhen Yang; Ahmad, M. S.; Ali, Shoukath M.; Ahmad, Imran

doi:10.1016/j.tetlet.2004.07.084

Tetrahedron Letters

2004

DOI: 10.1016/j.tetlet.2004.07.084

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A new convenient method for the synthesis of cardiolipin

Zhen Yang Lin¹,

M. S. Ahmad²,

Shoukath M. Ali³

et al.

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Cited by 5 publications

(1 citation statement)

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“…Our initial studies revealed that alkyl protecting groups for phosphoserine NCAs, such as methyl, ethyl, and isopropyl, gave polymers with poor solubility in common solvents. Attempts to use other groups such as 2-cholorophenyl and 2-trimethylsilylethyl gave NCA monomers that were unstable and challenging to purify. Following these initial setbacks, we developed a more modular approach toward quickly testing suitable protecting groups.…”

mentioning

confidence: 99%

Controlled Synthesis of Phosphorylcholine Derivatives of Poly(serine) and Poly(homoserine)

Yakovlev

Deming

2015

J. Am. Chem. Soc.

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ABSTRACT:We report methods for the synthesis of polypeptides that are fully functionalized with desirable phosphorylcholine, PC, groups. Due to inherent challenges in the direct incorporation of the PC group into α-amino acid N-carboxyanhydride (NCA) monomers, we developed a synthetic approach that combined functional NCA polymerization with efficient postpolymerization modification. While poly(L-phosphorylcholine serine) was found to be unstable upon synthesis, we successfully prepared poly(L-phosphorylcholine homoserine) with controlled chain lengths, and found these to be water soluble with disordered chain conformations.

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mentioning

confidence: 99%

Controlled Synthesis of Phosphorylcholine Derivatives of Poly(serine) and Poly(homoserine)

Yakovlev

Deming

2015

J. Am. Chem. Soc.

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The physicochemical properties of cardiolipin bilayers and cardiolipin-containing lipid membranes

Lewis

McElhaney

2009

Biochimica et Biophysica Acta (BBA) - Biomembranes

232

187

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In this review article, we summarize the current state of biophysical knowledge concerning the phase behavior and organization of cardiolipin (CL) and CL-containing phospholipid bilayer model membranes. We first briefly consider the occurrence and distribution of CL in biological membranes and its probable biological functions therein. We next consider the unique chemical structure of the CL molecule and how this structure may determine its distinctive physical properties. We then consider in some detail the thermotropic phase behavior and organization of CL and CL-containing lipid model membranes as revealed by a variety of biophysical techniques. We also attempt to relate the chemical properties of CL to its function in the biological membranes in which it occurs. Finally, we point out the requirement for additional biophysical studies of both lipid model and biological membranes in order to increase our currently limited understanding of the relationship between CL structure and physical properties and CL function in biological membranes.

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Synthesis of short and long chain cardiolipins

Ali¹,

Ahmad²,

Koslosky³

et al. 2006

Tetrahedron

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A new convenient method for the synthesis of cardiolipin

Cited by 5 publications

References 16 publications

Controlled Synthesis of Phosphorylcholine Derivatives of Poly(serine) and Poly(homoserine)

Controlled Synthesis of Phosphorylcholine Derivatives of Poly(serine) and Poly(homoserine)

The physicochemical properties of cardiolipin bilayers and cardiolipin-containing lipid membranes

Synthesis of short and long chain cardiolipins

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