A new configuration for bar adsorptive microextraction (BAμE) for the quantification of biomarkers (hexanal and heptanal) in human urine by HPLC providing an alternative for early lung cancer diagnosis

Oenning, Anderson Luiz; Morés, Lucas; Dias, Adriana Neves; Carasek, Eduardo

doi:10.1016/j.aca.2017.02.034

Cited by 43 publications

(22 citation statements)

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“…The second study was published in 2017. At this time, the use of cork BAµE bars was extended to biological samples for determination of two potential lung cancer biomarkers (hexanal and heptanal) in human urine by HPLC-DAD [19]. In this study, the adsorptive bar surface was impregnated with 2,4-dinitrophenylhydrazine (DNPH) so that derivatization and extraction were accomplished simultaneously on the surface of the bar under acidic conditions.…”

Section: Cork As a Biosorbentmentioning

confidence: 99%

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Alternative Green Extraction Phases Applied to Microextraction Techniques for Organic Compound Determination

et al. 2019

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The use of green extraction phases has gained much attention in different fields of study, including in sample preparation for the determination of organic compounds by chromatography techniques. Green extraction phases are considered as an alternative to conventional phases due to several advantages such as non-toxicity, biodegradability, low cost and ease of preparation. In addition, the use of greener extraction phases reinforces the environmentally-friendly features of microextraction techniques. Thus, this work presents a review about new materials that have been used in extraction phases applied to liquid and sorbent-based microextractions of organic compounds in different matrices.

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Section: Cork As a Biosorbentmentioning

confidence: 99%

“…Scheme of the biobased bar-adsorptive microextraction (BAµ E) procedure to determine hexanal and heptanal in human urine by HPLC-DAD. Reproduced with permission from[19], Copyright Elsevier, 2017.…”

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Alternative Green Extraction Phases Applied to Microextraction Techniques for Organic Compound Determination

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“…Although the flotation method is an advance in the technique, there is still the difficulty of keeping the bar under constant stirring in the vortex. In this way, a new configuration using a stainless steel rod was proposed for the first time in our group, to keep the bar balanced [30]. Recently, our group also proposed the coupling of several agitators to allow the simultaneous use of several adsorptive bars to improve the high-throughput aspects of the technique [23].…”

Section: Introductionmentioning

confidence: 99%

Application of bar adsorptive microextraction (BAµE) for the determination of pesticides and emerging contaminants in water used for rice cultivation in southern Brazil

et al. 2020

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Brazil is among the ten largest rice producers in the world, concentrating its production in the southern region. Anthropic activities, such as the disposal of chemicals in the ecosystem and consequently in the aquatic environment, end up harming the availability and quality of the water. Here, we developed an analytical method based on BAµE with WAX as an extraction phase for the determination of 5 pesticides and 2 emerging contaminants in water samples used in rice cultivation by HPLC-DAD. The method was fully optimized through univariate and multivariate approaches. The optimized condition was obtained with 145 min of extraction time, without salt addition and 35 min of desorption time using 250 μL of MeOH:AcEt (60:40, v/v). A reduced mass of extraction phase (around 4 mg) and sample and solvent volumes (15 mL and 300 µL, respectively) were used. The bars have a low cost and can be used up to 20 times without loss of extraction efficiency. Furthermore, the developed method presented high-throughput, because it uses a Voltage Regulator Variac system that allows the coupling of six magnetic stirrers simultaneously. The LODs ranged from 1.67 to 2.50 µg L −1 and the LOQs ranged from 5.00 to 7.50 µg L −1 ; both were below the VMP established by Ordinance 2.914/2011/MS for drinking water. Relative recoveries applied to the sample ranged from 80 to 121%. The intra-day and inter-day precision were up to 14% and 19%, respectively. The results were satisfactory, in accordance with the validation guidelines of the AOAC. Twenty-four samples collected in the Camboriú River Basin, which is influenced by rhiziculture, were analyzed and the analytes were not detected, as they are below the limits obtained in this method.

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“…Regarding the recent publications, raw cork-based approaches have been highlighted in microextraction methodologies whereas they exhibit some unique analytical features that allow for "green", sustainable, and efficient procedures that are relevant to the current environmental concerns [30][31][32][33][34][35][36][37][38]. Table 1 points out the analytical features of the recent applications using raw cork-based methodologies for the extraction of different analytes from various matrices.…”

Section: Introductionmentioning

confidence: 99%

“…Afterward, the resulting powder is conditioned with acetonitrile, and it is ready to be applied as sorbent phase. Raw cork powder has been successfully applied in different microextraction approaches such as bar adsorptive microextraction [30,31], disposable pipette extraction [32,35,36], thin film-solid phase microextraction [33], and rotating disk sorptive extraction [34] as a biosorbent for the reliable determination of organic micropollutants, toxic metals, UV filters, endocrine disruptors, and compounds in aqueous samples as well as pharmaceuticals and lung cancer biomarkers in human urine. Cork exhibits significant hydrophobicity and a number of aromatic rings that can undergo effective π-π interactions with the analytes and substantially enhance the preconcentration ability of the extraction procedures.…”

Section: Introductionmentioning

confidence: 99%

Returning to Nature for the Design of Sorptive Phases in Solid-Phase Microextraction

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Green analytical chemistry principles aim to minimize the negative impact of analytical procedures in the environment, which can be considered both at close (to ensure the safety of the analysts) and global (to conserve our natural resources) levels. These principles suggest, among other guidelines, the reduction/minimization of the sample treatment and the use of renewable sources when possible. The first aspect is largely fulfilled by microextraction, which is considered to be among the greenest sample treatment techniques. The second consideration is attainable if natural products are used as raw materials for the preparation of new extraction phases. This strategy is in line with the change in our production system, which is being gradually moved from a linear model (take-make-dispose) to a circular one (including reusing and recycling as key terms). This article reviews the potential of natural products as sorbents in extraction and microextraction techniques from the synergic perspectives of two research groups working on the topic. The article covers the use of unmodified natural materials and the modified ones (although the latter has a less green character) to draw a general picture of the usefulness of the materials.Separations 2020, 7, 2 2 of 22 principle identifies one of the trends of current research in analytical sciences, it is difficult to be applied when complex samples containing the analytes at very low concentrations are processed. In such scenarios, the simplification of the sample treatment and the reduction of the sources applied (reagents, energy) can be a more practical objective, at least currently. Microextraction techniques fulfill the latter criteria [8], and they are considered among the greenest sample treatment techniques [9].Microextraction techniques have evolved in the last decade following some key trends. Among them, the development of new extraction phases can be highlighted, considering the context of this review article. In this evolution, the tenth (use of renewable resources) and eleventh (replace or remove toxic reagents) principles of GAC are especially relevant [7]. In the liquid microextraction context, environmentally friendly solvents [10,11] such as CyreneTM [12] and deep eutectic solvents [13] are clear examples of this progress.The paradigm of our production system, which up to now has been based on a linear "take-make-dispose" model, is progressively changed to a circular model [14] where reusing, repairing, refurbishing, and recycling appear as key terms. The use of surpluses of natural products as raw materials for the preparation of new sorbents is an interesting contribution of analytical chemistry for changing the production model. This review article, which combines the vision of two research groups working in the topic, tries to draw the general picture of the potential of natural products for the synthesis of new sorptive phases in solid phase extraction and solid phase microextraction. The article will cover strategies with different green characterist...

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A new configuration for bar adsorptive microextraction (BAμE) for the quantification of biomarkers (hexanal and heptanal) in human urine by HPLC providing an alternative for early lung cancer diagnosis

Cited by 43 publications

References 32 publications

Alternative Green Extraction Phases Applied to Microextraction Techniques for Organic Compound Determination

Alternative Green Extraction Phases Applied to Microextraction Techniques for Organic Compound Determination

Application of bar adsorptive microextraction (BAµE) for the determination of pesticides and emerging contaminants in water used for rice cultivation in southern Brazil

Returning to Nature for the Design of Sorptive Phases in Solid-Phase Microextraction

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