A new concept of integrated cardiopulmonary bypass circuit

Mueller, Xavier M.; Jochheim, David; Augstburger, Monique; Horisberger, Judith; Godar, Gilles; Segesser, Ludwig K. von

doi:10.1016/s1010-7940(02)00086-6

Cited by 37 publications

(22 citation statements)

References 15 publications

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“…OPCAB procedures were revisited in this context [8]. Other investigators have focused on new developments of CPB comprising minimized extracorporeal bypass systems in order to reduce foreign surfaces [9]. The newly developed CCECC system, which was used in this study, is based on a concept of a compactly built closed total CPB circuit.…”

Section: Discussionmentioning

confidence: 99%

Comparison of minimally invasive closed circuit extracorporeal circulation with conventional cardiopulmonary bypass and with off-pump technique in CABG patients: selected parameters of coagulation and inflammatory system

Wippermann

Albes

Hartrumpf

et al. 2005

European Journal of Cardio-Thoracic Surgery

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Section: Discussionmentioning

confidence: 99%

Comparison of minimally invasive closed circuit extracorporeal circulation with conventional cardiopulmonary bypass and with off-pump technique in CABG patients: selected parameters of coagulation and inflammatory system

Wippermann

Albes

Hartrumpf

et al. 2005

European Journal of Cardio-Thoracic Surgery

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“…The hemolysis on CPB is also attributed to blood contact with the pericardium, excessive negative pressure, and coaspiration of blood with air (2). Today, the tendency to completely remove the CS during CPB has been shown to reduce systemic inflammatory response clinically and experimentally (8)(9)(10). Additionally, the CS has been replaced with alternatives such as cell salvage (CeS) improving biocompatibility (11).…”

mentioning

confidence: 99%

A Novel Device for Reducing Hemolysis Provoked by Cardiotomy Suction During Open Heart Cardiopulmonary Bypass Surgery: A Randomized Prospective Study

et al. 2006

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Since the inception of cardiopulmonary bypass (CPB), little progress has been made concerning the design of cardiotomy suction (CS). Because this is a major source of hemolysis, we decided to test a novel device (Smartsuction [SS]) specifically aimed at minimizing hemolysis during CPB in a clinical setting. Block randomization was carried out on a treated group (SS, n=28) and a control group (CTRL, n=26). Biochemical parameters were taken pre-, peri-, and post CPB and were compared between the two groups using the Student's t-test with statistical significance when P<0.05. No significant differences in patient demographics were observed between the two groups. Lactate dehydrogenase (LDH) and plasma free hemoglobin (PFH) pre-CPB were comparable for the CTRL and SS groups, respectively. LDH peri-CPB was 275+/-100 U/L versus 207+/-83 U/L for the CTRL and SS groups, respectively (P<0.05). PFH was 486+/-204 mg/L versus 351+/-176 mg/L for the CTRL and SS groups, respectively (P<0.05). LDH post CPB was 354+/-116 U/L versus 275+/-89 U/L for the CTRL and SS groups, respectively (P<0.05). PFH was 549+/-271 mg/L versus 460+/-254 mg/L for the CTRL and SS groups, respectively (P<0.05). Preoperative hematocrit (Hct) of 43+/-5% (CTRL) versus 37+/-5% (SS), and hemoglobin (Hb) of 141+/-16 g/L (CTRL) versus 122+/-17 g/L (SS) were significantly lower in the SS group. However, when normalized (N), the SS was capable of conserving Hct, Hb, and erythrocyte count perioperatively. Erythrocytes (N) were 59+/-5% (CTRL) versus 67+/-9% (SS); Hct (N) was 59+/-6% (CTRL) versus 68+/-9% (SS), and Hb (N) was 61+/-6% (CTRL) versus 70+/-10% (SS) (all P<0.05). This novel SS device evokes significantly lowered blood PFH and LDH values peri- and post CPB compared with the CTRL blood using a CS system. The SS may be a valuable alternative compared to traditional CS techniques.

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“…Haemodilution-associated low haematocrits are linked with higher morbidity and mortality rates. 4 Reduction in haemodilution is also associated with improved gas exchange efficiency 5 and a diminished inflammatory response. 6 With a static prime volume of 190ml, the Admiral offers a reduction in prime volume and surface contact area compared with a number of commercially available oxygenators (Table 2).…”

Section: Admiral Efficiencymentioning

confidence: 99%

Clinical evaluation of the Admiral 1.35m2 hollow-fibre membrane oxygenator

Issitt¹,

Cumberland²,

Clements³

et al. 2008

Perfusion

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This prospective study was designed to evaluate the fundamental clinical performance of a new, small surface area oxygenator. Data were collected from twenty patients undergoing first-time coronary artery bypass grafting using this device. This study focuses on how the reduction of surface area and prime volume affects the essential function of the oxygenator in terms of oxygenation efficiency, heat transference, membrane pressure drops, haemolysis and safety. Oxygenation efficiency was deemed to be well within acceptable margins, even at high flows, over a temperature range of 32-36°C. Heatexchanger performance was assessed by recording the heater/chiller water temperature compared to retrospective data from a current standard oxygenator. Heater/ chiller water temperatures were on average 0.3°C higher with the small surface oxygenator than the standard data. The air handling of the device was excellent and extremely safe. Haemolysis, measured as plasma free haemoglobin, did not increase during bypass (p>0.05). This new oxygenator offers a reduced surface area and priming volume while still ensuring an acceptable safety reserve and performance. Perfusion (2008) 23, 33-38.

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A new concept of integrated cardiopulmonary bypass circuit

Cited by 37 publications

References 15 publications

Comparison of minimally invasive closed circuit extracorporeal circulation with conventional cardiopulmonary bypass and with off-pump technique in CABG patients: selected parameters of coagulation and inflammatory system

Comparison of minimally invasive closed circuit extracorporeal circulation with conventional cardiopulmonary bypass and with off-pump technique in CABG patients: selected parameters of coagulation and inflammatory system

A Novel Device for Reducing Hemolysis Provoked by Cardiotomy Suction During Open Heart Cardiopulmonary Bypass Surgery: A Randomized Prospective Study

Clinical evaluation of the Admiral 1.35m2 hollow-fibre membrane oxygenator

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