A new cation-modified Al-polyacrylamide (CAPAM) flocculant was prepared by the in situ polymerization of acrylamide (AM) and (2-methacryloyloxyethyl) trimethyl ammonium chloride (DMC) with Al(OH) 3 sol. The optimum preparation conditions were obtained by a one-factor experimental design: as the amount of AlCl 3 was fixed at 0.025 mol, the polymerization time, polymerization temperature, n(AM) : n(AlCl 3 ), n(DMC) : n(AlCl 3 ), and n(K 2 S 2 O 8 ) : n(AM) were 4 h, 70 C, 8, 0.9, and 1.82 3 10 23 , respectively. The CAPAM was characterized by thermogravimetric analysis, Fourier transform infrared spectroscopy, scanning electron microscopy, and transmission electron microscopy. The solid-liquid separation performance of the CAPAM was evaluated in terms of water content. The CAPAM showed better flocculation performance than cationic polyacrylamide and polyaluminum sulfate at a fixed concentration of 0.3% in waste drilling fluid and tended to perform well in alkaline solution.