A New Combination Chemotherapy for Resistant Hodgkin Disease

Vinciguerra, Vincent

doi:10.1001/jama.1977.03270280035017

Cited by 33 publications

(3 citation statements)

References 7 publications

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“…[4,34] mit 62% Vollremissionen angegeben, wfihrend Clamon [13] bei keinem von 9 Patienten eine Vollremission erreichte. ABVS enthfilt Streptozotozin (,,S") statt Dacarbazin und ffihrte bei den Erstbeschreibern zu 30% (3 von 10) Vollremissionen [40]. B-DOPA [29] erh~ilt Vincristin (,,0") statt Vinblastin und zusfitzlich Prednison (,,P").…”

Section: Ergebnisse: Remissionszahlenunclassified

“…Dennoch rezidivierten 30% der Patienten, so dab nur 50 bis 60% durch das MOPP-Protokoll eine Langzeitremission erreichten [17]. Die Suche nach nichtkreuzresistenten Chemotherapieprotokollen ffihrte zum ABVD-Schema von Bonadonna [3,5] und verwandten Chemotherapieprotokollen [9,14,18,22,27,29,32,33,40]. Die Suche nach nichtkreuzresistenten Chemotherapieprotokollen ffihrte zum ABVD-Schema von Bonadonna [3,5] und verwandten Chemotherapieprotokollen [9,14,18,22,27,29,32,33,40].…”

Section: Introductionunclassified

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Behandlungsergebnisse mit dem ABVD-Schema bei C-MOPP-resistentem Morbus Hodgkin

et al. 1981

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22 Patients were treated with ABVD, 19 (18 stage IV B 1 stage III B) could be evaluated. No patient with impaired but 7 of 13 patients with intact bone-marrow function achieved a complete remission. A complete remission was also achieved by all 4 patients with a treatment- and disease-free interval but only by 3 of 15 without a free interval. Pretreatment, histology, duration of disease, and age showed no clear prognostic significance with respect to induction of remission. Toxicity was severe especially in patients over 50 years of age. 2 patients discontinued therapy because of gastro-intestinal toxicity. 2 of 8 died of treatment-related causes (1 leukemia, 1 sudden cardiac death). In 3 patients with high-dose mediastinal irradiation a pneumonitis secondary to bleomycin contributed significantly to death. Our results suggest that ABVD is an effective salvage-regimen for some subgroups of MOPP-failures.

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Section: Ergebnisse: Remissionszahlenunclassified

Section: Introductionunclassified

Behandlungsergebnisse mit dem ABVD-Schema bei C-MOPP-resistentem Morbus Hodgkin

et al. 1981

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“…Im Stadium IIIA und B wird die komplement/ire Bestrahlung diskutiert.Echte Atternativen fiir die Primdrbehandtung oder ffir die Therapie MOPP-resistenter Patienten wurden entwickelt. Eine Remissionsrate yon 50% (davon 30% komplette Remissionen) liel3 sich bei MOPP-resistenten Patienten mit der Kombination von Bleomycin, Vinblastin, Adriamycin und Streptozocin (einem Nitrosourea-Antibiotikum) erzielen[94].Rezidive zytostatisch behandelter Patienten der Stadien III und IV treten hfiufig im Bereich primfirer Manifestationen auf. Etwa 60%[14], nach Tabelle 3.…”

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M. Hodgkin. Ergebnisse der Diagnostik und Therapie

Huhn¹,

Wilmanns²

1979

Klin Wochenschr

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Optimal treatment in Hodgkin's disease requires the knowledge of the stage the disease has reached. Laboratory tests, x-ray and scintigraphy, usually, are not sufficient, but biopsies of bone marrow and liver are necessary, in special cases supplemented by laparoscopy or explorative laparotomy with splenectomy. As treatment of choice, irradiation is favored for disease restricted to lymph nodes, and cytostatics for disease complicated by severe symptoms or by organ involvement. Diagnosis and therapy should be adapted to the individual patient. New therapeutic approaches must be compared with the sometimes excellent results obtained by several institutions.

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Combination Chemotherapy With Doxorubicin and Lomustine

Williams

Einhorn

1977

JAMA

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A New Combination Chemotherapy for Resistant Hodgkin Disease

Cited by 33 publications

References 7 publications

Behandlungsergebnisse mit dem ABVD-Schema bei C-MOPP-resistentem Morbus Hodgkin

Behandlungsergebnisse mit dem ABVD-Schema bei C-MOPP-resistentem Morbus Hodgkin

M. Hodgkin. Ergebnisse der Diagnostik und Therapie

Combination Chemotherapy With Doxorubicin and Lomustine

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