A new colorimetric method for the determination of nifedipine tablets by derivatization using 4-carboxyl-2,6-dinitrobenzene diazonium ion

Aderibigbe, Segun A.; Adegoke, Olajire A.

doi:10.1186/2228-5547-3-5

Cited by 9 publications

(8 citation statements)

References 19 publications

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“…The results showed that the titration value and colourimetric value for the ascorbic acid were consistent, indicating that each technique is appropriate for determining ascorbic acid. This result means that there was little or no interference of the excipient on the assay procedure [12]. Seven out of the nine brands were within the official titration specification of 95.0-107.50% BP (2018).…”

Section: Discussionmentioning

confidence: 78%

Evaluation of the Quality of Different Brands of Ascorbic Acid in Freetown, Sierra Leone

Lahai

Conteh

Mansaray

et al. 2021

Int J Pharm Pharm Sci

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Objective: This study evaluates the registration status and the quality of nine brands of Vitamin C sold in Freetown, Sierra Leone, using official and non-official methods of analysis. Methods: The parameters taken into consideration during the study include non-official methods (friability and disintegration) and the official methods (identification test, uniformity of dosage unit, and assay by titrimetric and colorimetric tests). The different brands of vitamin C were selected and classified as registered and unregistered based on the data derived from the National Medicines Regulatory Authority. Results: One vitamin C product collected was unregistered at the National medicines regulatory authority (Pharmacy Board of Sierra Leone). All nine vitamin C products met the requirements for uniformity of dosage unit. The vitamin C products also conformed to the BP specification for friability and identification test (retention factor). The identification test showed that each brand contained vitamin C (ascorbic acid). The disintegration test was not applicable for chewable tablets. Three of the four non-chewable vitamin C products complied with the BP specification for disintegration, while one failed and did not meet the requirement. The assay results for ascorbic acid using titration and colourimetric method were comparable and appropriate for determining vitamin C. Out of a total of nine samples; seven met the requirement for BP specification (Passed) for assay. In contrast, one product did not meet the BP requirement (failed), and one sample had more vitamin C than the Pharmacopoeia limit. Conclusion: Periodic quality evaluation and routine checks for pharmaceutical products can ascertain the quality of products, their storage conditions and identify potential counterfeit medications.

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Section: Discussionmentioning

confidence: 78%

Evaluation of the Quality of Different Brands of Ascorbic Acid in Freetown, Sierra Leone

Lahai

Conteh

Mansaray

et al. 2021

Int J Pharm Pharm Sci

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“…Several study showed that validation and estimation of STZ may be done using high-performance liquid chromatography (HPLC) [4], high-performance thin layer chromatography (HPTLC) [5,6] colorimetric method after chemical derivatization [7,8], and UVspectrophotometric methods both in combination with ofloxacin or gatifloxacin or alone [9,10]. Absence of sufficient experimental data of UVspectrophotometric methods for quantitative estimations of satranidazole (STZ) in pharmaceutical formulation using different classes of solvents influence to perform the present study.…”

Section: Introductionmentioning

confidence: 99%

Improved comprehensive analytical method for assessment of satranidazole in drug and product

Mazumder

Mahanti

Majumdar³

et al. 2020

Futur J Pharm Sci

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Background: The aim of the present investigation was to improve comprehensive analytical method for the assessment of satranidazole in drug and product with simple, economic, sensitive, and reproducible spectrophotometric method. The drug was analyzed in three different methods by using various solvents where satranidazole (STZ) showed different absorbance maxima (s) and sharp peaks in the first order derivative spectra. Beer's law range, correlation coefficient, apparent molar absorptivity, etc., were determined for each solvent using all the three methods. Results: All the results of analysis were found to be satisfactory which was validated statistically for various parameters and by performing recovery studies in accordance with international conference on harmonization (ICH) guidelines. The developed methods were also compared statistically using one way analysis of variance (ANOVA). Conclusion: Three different spectrophotometric methods were developed for satranidazole (STZ) using various inorganic and organic solvents. The analytical methods are found to be simple, sensitive, rapid, specific, and economic, and it can be conveniently employed for the routine analysis, quality control. The sample recoveries from the formulation were in good agreement with its respective label claim.

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“…It has been successfully applied to the assay of many clinically useful drugs. The chemical derivatization methodologies are based on absorption spectroscopy [5][6][7][8][9][10][11][12][13][14][15][16] and liquid chromatography [17].…”

Section: Introductionmentioning

confidence: 99%

Modeling of 4-Carboxyl-2,6-dinitrobenzenediazonium Ion (CDNBD) Hydrolysis Through Addition of Water and Alkaline Buffer in a Strongly Acidic Medium

Thomas

Bioku

2015

J Solution Chem

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The transition from aryl diazonium reagent solution to a crystalline form has substantial merits, namely augmented stability and versatility. Absorbance decay data was from photometric titration with hydroxyl ion, supplied incrementally by water and alkaline buffer (pH 12.0), to 4-carboxyl-2,6-dinitrobenzenediazonium ion (CDNBD) and simpler analogs in a strongly acidic medium. The data were fitted to nested models (mono-and bi-exponential decay). Akaike's Information Criterion was used for statistical model comparison. Preferred model identification shows simpler diazonium analogs are less reactive towards hydroxyl ion when alkaline buffer solution is the diluting medium. In contrast, CDNBD hydrolysis is faster when an alkaline diluting medium is added, owing to profound positive effect of strong electron withdrawing groups on its electrophilic reactivity. Acidic diluting medium was shown, unambiguously, as a critical requirement for maintaining CDNBD, in an acidic solution as the cation species. Key input process variables were reliably predicted, using model parameters like V 1=2 and V T 1=2 , thus giving direction for optimal synthesis of crystalline CDNBD.

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A new colorimetric method for the determination of nifedipine tablets by derivatization using 4-carboxyl-2,6-dinitrobenzene diazonium ion

Cited by 9 publications

References 19 publications

Evaluation of the Quality of Different Brands of Ascorbic Acid in Freetown, Sierra Leone

Evaluation of the Quality of Different Brands of Ascorbic Acid in Freetown, Sierra Leone

Improved comprehensive analytical method for assessment of satranidazole in drug and product

Modeling of 4-Carboxyl-2,6-dinitrobenzenediazonium Ion (CDNBD) Hydrolysis Through Addition of Water and Alkaline Buffer in a Strongly Acidic Medium

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