A new colonial type of N. gonorrhoeae.

Chan, K; Wiseman, G. M.

doi:10.1136/sti.51.4.251

Cited by 5 publications

(7 citation statements)

References 15 publications

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“…The apparent coloration of colonies of Neisseria gonorrhoeae propagated on clear, solid media has been reported to range from light cream to dark brown-black (3,4,5,10,11,14). Recently this variation has been explained to be based on the occurrence of surface proteins affecting the intracellular aggregation and thus the optical properties (apparent color and opacity) of the gonococcal colonies (23,24,25).…”

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confidence: 99%

Studies on gonococcus infection. XIII. Occurrence of color/opacity colonial variants in clinical cultures

James¹,

Swanson²

1978

Infect Immun

195

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Colonial variants of Neisseria gonorrhoeae differing in color and opacity characteristics are distributed differently between male urethral and female cervical cultures. Colonial characteristics of cultures isolated from female cervices differ with time of isolation within the menstrual cycle and use of oral contraceptives. These differences may reflect selective forces in the ecology of the cervix, particularly proteolytic enzymes in cervical mucus and menstrual blood. Cycle changes in the characteristics of gonococci isolated from females may have implications for pathogenesis of gonococcal infections and immune reponse to the gonococcus.

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confidence: 99%

Studies on gonococcus infection. XIII. Occurrence of color/opacity colonial variants in clinical cultures

James¹,

Swanson²

1978

Infect Immun

195

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“…Although the size of the clear areas varied from strain to strain, no definite differences were seen between Op and Tr bacteria or in Tr bacteria before and after inoculation into chicken embryos. DISCUSSION Intravenous inoculation of 11-day-old chicken embryos has been used previously as a model for gonococcal (5,6,8)-, meningococcal (4), and streptococcal (24) infections. Colonial types of gonococci which have proven to be virulent for human volunteers (13) and chimpanzees (15) are considerably more lethal than the avirulent gonococcal colony types when injected intrave-nously into chicken embryos (5,6,8).…”

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confidence: 99%

“…(13,14) into four colony types initiated much investigative work into the pathogenetic mechanisms of this bacterium. It has been recognized for some time, however, that not all gonococcal colonies can be encompassed by this typing system (2,6,9). Recently, Swanson has studied gonococcal colonial variants which have similar edge morphology to that described by Kellogg but which include a wider variation in opacity and color (21).…”

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Gonococcal color and opacity variants: virulence for chicken embryos

Salit¹,

Gotschlich²

1978

Infect Immun

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Previous studies have noted that the prevalence of certain gonococcal colony types is influenced by the physiological state of the human host. Consequently eight different gonococcal strains were passed on clear typing medium, and opaque (Op) and transparent (Tr) variants of heavily pilated (P++) bacteria were selected. P++Op and P++Tr were injected into 11-day-old chicken embryos, and the resulting mortality was determined. In every case the Tr variants were more lethal to the embryos than were the Op variants (P = 0.01). P++Tr were stable in vivo, but chicken embryos injected with P++Op strains developed bacteremia with P++Tr organisms. However, chicken blood was not bactericidal for either colonial variant. These results indicate that transparent pilated bacteria may be more virulent than opaque pilated bacteria and that in vivo selection of transparent forms occurs.

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“…Differentiation of colonies under these lighting conditions was made according to criteria set out by the Kellogg group and by Jephcott and Reyn (1971). Type 1' newly described by Chan and Wiseman (1975), was also investigated. Type 1' resembles Type 1 and 2 colonies in physical characteristics but the colonies are granular, slightly crenated, and deeper gold in colour under oblique lighting.…”

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confidence: 99%