A new classification of ocular surface burns

Dua, Harminder S.; King, Anthony J; Joseph, Annie

doi:10.1136/bjo.85.11.1379

Cited by 262 publications

(216 citation statements)

References 21 publications

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“…We do find support for this hypothesis in some studies that have shown a decrease in the goblet cell density within the conjunctiva in chemical burns. 26 Moreover, most of the data on wound healing in chemical burns are obtained from animal experiments, wherein the limbus is selectively damaged with chemicals to produce limbal stem cell deficiency. However, in human eyes, ocular surface insult from chemical burns may go beyond damage to the limbal tissues.…”

Section: Histopathology Of Pannus a Fatima Et Almentioning

confidence: 99%

Ocular surface changes in limbal stem cell deficiency caused by chemical injury: a histologic study of excised pannus from recipients of cultured corneal epithelium

Anjum

Iftekhar

Sangwan

et al. 2007

Eye

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Purpose To report histopathologic changes of the ocular surface pannus in patients with severe limbal stem cell deficiency (LSCD). Methods Corneal and conjunctival pannus tissues from 29 patients undergoing ocular reconstruction with cultured limbal cell transplantation were included. The medical records of these patients were reviewed for demographics, aetiologic diagnosis, type of injury, interval between the initial insult and excision of pannus, and medical history involving human amniotic membrane (HAM) or limbal transplantation. The paraffin-embedded tissues were reviewed for epithelial changes, type-degree of fibrosis, degenerative changes, vascular changes, conjunctivalization of corneal surface, and evidence of residual HAM. We attempted a clinicopathologic correlation to understand the pathogenesis of pannus formation in LSCD. Results The 29 tissues were from 29 eyes of patients with primary aetiology of chemical burn in 89.6% (undetermined in 10.4%) of cases. The pannus showed epithelial hyperplasia in 62%, active fibrosis in 66%, severe inflammation in 21%, giant cell reaction in 28%, and stromal calcification in 14% cases. Goblet cells were seen over the cornea in 64% cases; their absence was associated with squamous metaplasia of the conjunctiva and with long duration of insult. Evidence of residual HAM was noted in 42% cases. ConclusionsThe commonest cause of severe LSCD is alkali-induced injury. Goblet cells over the cornea were seen in 60% of cases. HAM used for ocular surface reconstruction could persist for long periods within the corneal pannus, thus raising the need for further studies with long-term follow-up.

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Section: Histopathology Of Pannus a Fatima Et Almentioning

confidence: 99%

Ocular surface changes in limbal stem cell deficiency caused by chemical injury: a histologic study of excised pannus from recipients of cultured corneal epithelium

Anjum

Iftekhar

Sangwan

et al. 2007

Eye

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“…Ocular thermal burns are among the most severe ocular surface injuries and may lead to limbal stem cell deficiency (1,4) . While mild burns heal within a few days, moderate to severe chemical and thermal burns cause ischemic necrosis of the cornea, conjunctiva, sclera, iris, and ciliary body by damaging the surface epithelium.…”

Section: Discussionmentioning

confidence: 99%

“…Thermal burns may result from contact with various materials such as steam, boiling water, fireworks explosion, and molten metal (1) . The severity of the burn varies depending on the structure of the agent, duration of contact, and contact surface area (2) .…”

Section: Introductionmentioning

confidence: 99%

Molten metal-related ocular thermal burn: report on two cases

Arıcı¹,

İskeleli²,

Atalay³

et al. 2015

Arquivos Brasileiros De Oftalmologia

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We report two cases of severe thermal burns on the ocular surface and its adnexal appendages that developed secondary to exposure to molten heavy metal with a melting temperature of near-thousand degree Celsius. Despite aggressive intervention and strict monitoring, the profound inflammation caused significant damage to the ocular surface, ending up in an intractable infection with an unfavorable outcome. The heat of the molten metal at impact, the heat-retaining capacity of the heavy metal, the total area of the ocular surface exposed to the molten metal, and the duration of exposure determined the severity of the injury. The unfavorable outcome, despite an intensive treatment, in terms of visual acuity and cosmetic appearance, should be explicitly explained to the patient, and a psychiatrist consultation should be considered if necessary.

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“…Se analizaron 10 ojos de 10 pacientes que acudieron de urgencia a nuestro centro (monográfico de patología laboral) por accidentes laborales: quemaduras oculares grado III de la clasificación de Dua (29), es decir, con defectos corneales de 3 a 6 horas de afectación corneal y de 30-50% de lesión conjuntival. Tras recibir el tratamiento pautado, según método y protocolo, se realizó seguimiento clínico hasta su curación.…”

Section: Sujetos Materials Y Métodounclassified

Aplicación subconjuntival de concentrado de plaquetas plasmáticas en el tratamiento de quemaduras oculares: Resultados preliminares

Márquez-De-Aracena

Montero-De-Espinosa

Muñoz

et al. 2007

Arch Soc Esp Oftalmol

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RESUMENObjetivo: Se valoró la eficacia de la aplicación subconjuntival de concentrado de plaquetas plasmáticas autólogas en pacientes con quemaduras oculares. Método: Para ello se analizaron 10 ojos de 10 pacientes que sufrieron accidentes laborales por quemaduras oculares del mismo grado. Se establecieron dos tipos de tratamiento: al primer grupo, control, se le aplicó tratamiento médico tópico convencional; al segundo, se le añadió además, inyección subconjuntival de concentrado de plaquetas autólogas. Se estudió la evolución clínica, días que le incapacitaron dicha patología para su actividad laboral y seguimiento hasta su curación final. Resultados: Se encontraron diferencias entre el grupo de los tratados con concentrado de plaquetas autólogas subconjuntivales respecto al grupo con tratamiento médico tópico convencional, siendo más corto el tiempo de cicatrización de córnea (sig-ARTÍCULO ORIGINAL ABSTRACT Purpose: The efficiency of the subconjunctival application of autologous platelet concentrate in patients with ocular burns was assessed. Methods: This was carried out by analysing the effect of treatment in the eyes of 10 patients suffering from ocular burns as a result of work-related accidents. Two types of treatment were evaluated: the first group only received conventional topical medical treatment; and the second group, in addition, had subconjunctival injection of plasma platelet concentrate. The clinical condition of the patient and the period in which the disease prevented the patient from working were studied; monitoring was carried out until the burns had fully healed. Results: Statistically significant differences were found between the group treated with subconjunctival autologous platelet concentrate and the group treated with conventional topical medications, with

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A new classification of ocular surface burns

Cited by 262 publications

References 21 publications

Ocular surface changes in limbal stem cell deficiency caused by chemical injury: a histologic study of excised pannus from recipients of cultured corneal epithelium

Ocular surface changes in limbal stem cell deficiency caused by chemical injury: a histologic study of excised pannus from recipients of cultured corneal epithelium

Molten metal-related ocular thermal burn: report on two cases

Aplicación subconjuntival de concentrado de plaquetas plasmáticas en el tratamiento de quemaduras oculares: Resultados preliminares

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