A New Class of Stem Cells in South Africa: Introducing Induced Pluripotent Stem cells (iPS cells)

Ballo, Robea; Greenberg, L J; Kidson, Susan H.

doi:10.7196/samj.6604

Cited by 4 publications

(2 citation statements)

References 23 publications

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“…[5,6] We, and many groups around the world, immediately saw the potential of these cells to study development and have established 'disease-in-the-dish' models to help elucidate the cellular aetiology of diseases and for patient-specific drug-testing studies. [7] With the rapid exploration of iPSC technology and the burgeoning research output, it is not surprising that the first trial of iPSC for the treatment of agerelated macular degeneration is underway. [8] However, the rise of iPSC technology has brought into focus many new ethical questions that must be addressed and resolved.…”

mentioning

confidence: 99%

Towards guidelines for informed consent for prospective stem cell research

Greenberg¹,

Smith²,

Burman³

et al. 2015

S Afr J BL

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mentioning

confidence: 99%

Towards guidelines for informed consent for prospective stem cell research

Greenberg¹,

Smith²,

Burman³

et al. 2015

S Afr J BL

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“…It was Dr Janine Scholefield, [7] originally trained by Prof. Jacquie Greenberg in Human Genetics, and at the time working at the University of Oxford, who brought our attention to the new cells on the block, namely induced pluripotent stem cells (iPSC). [8,9] It was evident to us that the time was ripe to set up a stem cell research facility at UCT. [10] Dr Robea Ballo, also originally from the Department of Human Genetics (in the 1980s) was invited to join the group and establish the iPSC facility.…”

Section: The Uct Stem Cell Initiative and The New Eramentioning

confidence: 99%

The rise of developmental genetics – a historical account of the fusion of embryology and cell biology with human genetics and the emergence of the Stem Cell Initiative

2016

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Examining the potentials of stem cell therapy in reducing the burden of selected non-communicable diseases in Africa

Atewologun,

Okesanya,

Okon

et al. 2024

Stem Cell Res Ther

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Stem cell therapy (SCT) is a promising solution for addressing health challenges in Africa, particularly non-communicable diseases (NCDs). With their regenerative potential, stem cells have the inherent capacity to differentiate into numerous cell types for tissue repair. Despite infrastructural, ethical, and legal challenges, SCT holds immense promise for managing chronic illnesses and deep-seated tissue injuries. The rising prevalence of NCDs in Africa highlights the need for innovative strategies and treatment options. SCT offers hope in combating conditions like burns, osteoarthritis, diabetes, Alzheimer’s disease, stroke, heart failure and cancer, potentially reducing the burden of NCDs on the continent. Despite SCT’s opportunities in Africa, there are significant obstacles. However, published research on SCT in Africa is scarce, but recent initiatives such as the Basic School on Neural Stem Cells (NSC) express interest in developing NSC research in Africa. SCT research in African regions, notably on neurogenesis, demonstrates a concentration on studying neurological processes in indigenous settings. While progress has been made in South Africa and Nigeria, issues such as brain drain and impediments to innovation remain. Clinical trials have investigated the efficacy of stem cell treatments, emphasising both potential benefits and limitations in implementing these therapies efficiently. Financing research, developing regulatory frameworks, and resolving affordability concerns are critical steps toward realizing the potential of stem cell treatment in Africa.

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A New Class of Stem Cells in South Africa: Introducing Induced Pluripotent Stem cells (iPS cells)

Cited by 4 publications

References 23 publications

Towards guidelines for informed consent for prospective stem cell research

Towards guidelines for informed consent for prospective stem cell research

The rise of developmental genetics – a historical account of the fusion of embryology and cell biology with human genetics and the emergence of the Stem Cell Initiative

Examining the potentials of stem cell therapy in reducing the burden of selected non-communicable diseases in Africa

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