A new class of nifuroxazide analogues: Synthesis of 5-nitrothiophene derivatives with antimicrobial activity against multidrug-resistant Staphylococcus aureus

Substituted benzoic acid benzylidene/furan-2-yl-methylene hydrazides: synthesis, antimicrobial evaluation and QSAR analysis

“…1 There is a real need for discovery of new compounds endowed with antimicrobial activity, possibly acting through mechanisms of actions, which are distinct from those of well known classes of antimicrobial agents to which many clinically relevant pathogens are now resistant. 2 Hydrazide analogues also possess other biological activities like anticonvulsant, 3 antidepressant, 4 anti-inflammatory, 5 antimalarial, 6 antimycobacterial, 7 anticancer 8 and antimicrobial [9][10][11][12] activities. QSAR is one of the oldest and most widely used methods in computational drug design.…”

Crystal structure of N 2,N 6-bis(1-hydrazinyl-2-methyl-1-oxopropan-2-yl) pyridine-2,6-dicarboxamide, C15H23N7O4

“…Several hydrazidehydrazone derivatives have shown antimicrobial, antiviral, antimalarial, anticonvulsant, antiinflammatory, antituberculosis, antitumor, antiplatelet aggregation, antileishmanial, analgesic and antimalarial properties [4][5][6][7][8][9][10][11][12]. Furthermore, various substituted pyridines were recorded to exhibit antibacterial, anti-inflammatory and antitumor activity [13][14][15].…”

Synthesis, in Vitro Antimicrobial Activity of Schiff’s Base, Azetidinones and Thiazolidinones

“…Structurally, a Schiff's base (also known as imine or azomethine) is a nitrogen analogue of an aldehyde or ketone in which the carbonyl group has been replaced by an imine or azomethine group. Schiff's bases of pyrazole aldehydes and aromatic amines exhibit a wide range of biological activities such as antifungal [1], antibacterial [2] and antitubercular [3] etc. The biological significance of this class of compounds impelled us to continue working on the synthesis of new schiff's bases of pyrazole derivatives.…”