A new circular RNA–encoded protein BIRC6-236aa inhibits transmissible gastroenteritis virus (TGEV)–induced mitochondrial dysfunction

Zhao, Xuefei; Guo, Jianxiong; Wang, Xinyue; Lin, Jiadi; Liu, Zhihao; Xu, Chunmei; Zhang, Di; Tong, Dewen

doi:10.1016/j.jbc.2022.102280

Cited by 2 publications

(2 citation statements)

References 63 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, the mitochondrial permeability transition is caused by the abnormal opening of the mitochondrial permeability transition pore (mptp) regulated by the voltage-dependent anion-selective channel protein 1 (VDAC)-cyclophilin D (CypD) complex, which is a critical step in the process of mitochondrial dysfunction. Zhao et al (2022) found that circBIRC6-2 encodes a new protein named BIRC6-236aa. This protein inhibits TGEV-induced mptp opening in TGEV infection.…”

Section: Circrna-encoded Proteins and Virusesmentioning

confidence: 99%

Newly discovered circRNAs encoding proteins: recent progress

Shi,

Liao,

et al. 2023

Front. Genet.

View full text Add to dashboard Cite

Circular RNA (circRNA) is a special class of noncoding RNA molecules and the latest research hotspot in the field of RNA. CircRNA molecules have a closed loop structure, which is not affected by RNA exonuclease and has the characteristics of more stable expression. Previous studies have shown that circRNA molecules are rich in microRNA (miRNA) binding sites and act as miRNA sponges in cells. By interacting with miRNAs associated with tumors and other diseases, circRNAs play an important regulatory role. However, circRNAs have recently been found to have small open reading frames that enable them to encode peptides/proteins. These proteins have been reported to play an important role in the mechanism of regulation of a variety of diseases and have great potential in the diagnosis and treatment of diseases. In this review, we summarize the mechanism of action of the newly discovered circRNA-coding proteins since 2022 and briefly describe their research process. In addition, we also discuss the prediction model of the functional sites and encoded proteins of circRNAs, which provides a potential idea for future research on circRNAs.

show abstract

Section: Circrna-encoded Proteins and Virusesmentioning

confidence: 99%

Newly discovered circRNAs encoding proteins: recent progress

Shi,

Liao,

et al. 2023

Front. Genet.

View full text Add to dashboard Cite

show abstract

“…[ 10 – 12 ] When CypD interacts with other proteins in the mitochondrial membrane, it promotes the opening of the mPTP. [ 13 ] This interaction is particularly influenced by the level of Ca 2+ in the mitochondria. CypD acts as a positive regulator of mPTP, facilitating its opening in response to different stimuli.…”

Section: Introductionmentioning

confidence: 99%

Rational design peptide inhibitors of Cyclophilin D as a potential treatment for acute pancreatitis

Li,

Liu,

Lai

et al. 2023

Medicine

View full text Add to dashboard Cite

Cyclophilin D (CypD) is a mitochondrial matrix peptidyl prolidase that regulates the mitochondrial permeability transition pore. Inhibition of CypD was suggested as a therapeutic strategy for acute pancreatitis. Peptide inhibitors emerged as novel binding ligand for blocking receptor activity. In this study, we present our computational approach for designing peptide inhibitors of CypD. The 3-D structure of random peptides were built, and docked into the active center of CypD using Rosetta script integrated FlexPepDock module. The peptide displayed the lowest binding energy against CypD was further selected for virtual iterative mutation based on virtual mutagenesis and molecular docking. Finally, the top 5 peptides with the lowest binding energy was selected for validating their affinity against CypD using inhibitory assay. We showed 4 out of the selected 5 peptides were capable for blocking the activity of CypD, while WACLQ display the strongest affinity against CypD, which reached 0.28 mM. The binding mechanism between WACLQ and CypD was characterized using molecular dynamics simulation. Here, we proved our approach can be a robust method for screening peptide inhibitors.

show abstract

A new circular RNA–encoded protein BIRC6-236aa inhibits transmissible gastroenteritis virus (TGEV)–induced mitochondrial dysfunction

Cited by 2 publications

References 63 publications

Newly discovered circRNAs encoding proteins: recent progress

Newly discovered circRNAs encoding proteins: recent progress

Rational design peptide inhibitors of Cyclophilin D as a potential treatment for acute pancreatitis

Contact Info

Product

Resources

About