A New Cholesterol Biosynthesis and Absorption Disorder Associated With Epilepsy, Hypogonadism, and Cerebro-Cerebello-Bulbar Degeneration

Korematsu, Seigo; Uchiyama, Shin-ichi; Honda, Akira; Izumi, Tatsuro

doi:10.1016/j.pediatrneurol.2014.01.050

Cited by 3 publications

(2 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our findings in regard to the metabolism of cholesterol and metabolites could reflect upregulated demand and metabolism of cholesterol in the brain as cholesterol is a main component of cell membranes and essential in the nervous system 54 . Increased cholesterol is consistent with upregulation of hippocampal VD3 metabolites and downregulation of 25-(OH)-VD3, eventually indicating high demand and rapid turnover of 25-(OH)-VD3 as discussed above.…”

Section: Discussionmentioning

confidence: 75%

Exploratory Metabolomics Profiling in the Kainic Acid Rat Model Reveals Depletion of 25-Hydroxyvitamin D3 during Epileptogenesis

Heischmann

Quinn

Cruickshank‐Quinn

et al. 2016

Sci Rep

View full text Add to dashboard Cite

Currently, no reliable markers are available to evaluate the epileptogenic potential of a brain injury. The electroencephalogram is the standard method of diagnosis of epilepsy; however, it is not used to predict the risk of developing epilepsy. Biomarkers that indicate an individual’s risk to develop epilepsy, especially those measurable in the periphery are urgently needed. Temporal lobe epilepsy (TLE), the most common form of acquired epilepsy, is characterized by spontaneous recurrent seizures following brain injury and a seizure-free “latent” period. Elucidation of mechanisms at play during epilepsy development (epileptogenesis) in animal models of TLE could enable the identification of predictive biomarkers. Our pilot study using liquid chromatography-mass spectrometry metabolomics analysis revealed changes (p-value ≤ 0.05, ≥1.5-fold change) in lipid, purine, and sterol metabolism in rat plasma and hippocampus during epileptogenesis and chronic epilepsy in the kainic acid model of TLE. Notably, disease development was associated with dysregulation of vitamin D3 metabolism at all stages and plasma 25-hydroxyvitamin D3 depletion in the acute and latent phase of injury-induced epileptogenesis. These data suggest that plasma VD3 metabolites reflect the severity of an epileptogenic insult and that a panel of plasma VD3 metabolites may be able to serve as a marker of epileptogenesis.

show abstract

Section: Discussionmentioning

confidence: 75%

Exploratory Metabolomics Profiling in the Kainic Acid Rat Model Reveals Depletion of 25-Hydroxyvitamin D3 during Epileptogenesis

Heischmann

Quinn

Cruickshank‐Quinn

et al. 2016

Sci Rep

View full text Add to dashboard Cite

show abstract

“…One of the dominant components of human cell membranes and constituent substances in the CNS is cholesterol. [ 22 ] Evidence also advocates steroids antidepressant activity. [ 23 ] Steroids present in the hexane extract could be a good reason for its antidepressant effects in our study during the FST.…”

Section: Discussionmentioning

confidence: 99%

Extraction and fractionation of the seaweed Sargassum plagyophylum and evaluation of fractions on depression induced by interferon alpha in mice

Yegdaneh

Mesripour²,

Gholamzadeh³

2022

Adv Biomed Res

View full text Add to dashboard Cite

Background: Marine organisms such as seaweeds, produce potent chemicals with characteristic biological features. Sargassum species have great potential to be used for neuronal protection as part of nutraceuticals. The aim was to investigate the effects of hexane and methanol extracts of Sargassum plagyophylum from the Persian Gulf on depression induced by interferon-α (IFNa) in mice. Materials and Methods: S. plagyophylum was extracted by maceration with methanol-ethyl acetate solvent (1:1). The extract was evaporated and partitioned by hexane and methanol solvents. Male mice were used, depression was induced by SC injecting IFNα (16 × 10 5 IU /kg) for 6 days. Animals were subject to the forced swimming test (FST) after the locomotor test, on day 7. The extracts were administered IP either one single dose (acute) before the test, or simultaneously with IFNα (sub-acute). Results: The locomotor activity was not different from control values. IFNa increased the immobility time during FST (140 ± 14 s vs. control group 95 ± 9 s, P < 0.05). Hexane extract acute (40 mg/kg) injection was not effective while its sub-acute (20 mg/kg) injection reduced immobility time (46 ± 8 s, P < 0.001 vs. IFNa alone). Methanol extract acute (20 mg/kg) and sub-acute (20 mg/kg) administration significantly reduced immobility during the FST (78 ± 20 s, and 72 ± 8 s respectively, P < 0.05 vs. IFNa alone). Conclusion: S. plagyophylum has antidepressant effects, the hexane extract could prevent depression while the methanol extract not only prevented but also treated depression induced by IFNa in mice. Since this species is abundant in the Persian Gulf further clinical studies on its psychological effects are warranted.

show abstract

Fucosterol, a sterol extracted from Sargassum fusiforme, shows antidepressant and anticonvulsant effects

Zhen

Quan

Jiang

et al. 2015

European Journal of Pharmacology

View full text Add to dashboard Cite

A New Cholesterol Biosynthesis and Absorption Disorder Associated With Epilepsy, Hypogonadism, and Cerebro-Cerebello-Bulbar Degeneration

Cited by 3 publications

References 6 publications

Exploratory Metabolomics Profiling in the Kainic Acid Rat Model Reveals Depletion of 25-Hydroxyvitamin D3 during Epileptogenesis

Exploratory Metabolomics Profiling in the Kainic Acid Rat Model Reveals Depletion of 25-Hydroxyvitamin D3 during Epileptogenesis

Extraction and fractionation of the seaweed Sargassum plagyophylum and evaluation of fractions on depression induced by interferon alpha in mice

Fucosterol, a sterol extracted from Sargassum fusiforme, shows antidepressant and anticonvulsant effects

Contact Info

Product

Resources

About