A new chamigrane sesquiterpene from the basidiomycete <i>Antrodiella albocinnamomea</i>

Luo, Cheng; Lou, Dengji; Li, Yin-Fei; Yang, Linlin; Shao, Lin-Jiao; Liu, Ji‐Kai; Yang, Xiaoyan

doi:10.1080/10286020.2022.2064283

Cited by 3 publications

(1 citation statement)

References 15 publications

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“…In the fungal kingdom, basidiomycetes produce a wide variety of sesquiterpenoids with an extensive repertoire of backbone structures (Chen & Liu, 2017 ; Fraga, 2013 ; Kramer & Abraham, 2012 ). For instance, several sesquiterpenoids possessing rare/unique/novel backbone skeletons have been isolated and characterized from basidiomycetous fungi (Luo et al, 2022 ; Nakashima et al, 2019 ; Niu et al, 2020 ). Genome sequences of many fungi have been determined and released through the 1000 Fungal Genomes Project (Grigoriev et al, 2014 ), leading to a new research paradigm associated with the functionomics of enzymes.…”

Section: Introductionmentioning

confidence: 99%

Biocatalyst collection and heterologous expression of sesquiterpene synthases from basidiomycetous fungi: Discovery of a novel sesquiterpene hydrocarbon

Masunaga

Kitaoka

Ichinose

2022

Microbial Biotechnology

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Basidiomycetes produce a wide variety of sesquiterpenoids, which attract significant interest in pharmaceutical and industrial applications. Structural diversification of sesquiterpenoids is performed by sesquiterpene synthases (STSs), which produce a wide array of backbone structures; therefore, functional characterization and increased biocatalyst collection of STSs are important for expanding scientific knowledge and meeting the needs of advanced biotechnology. Gene identification and functional annotation of STSs from the basidiomycetous fungi Agaricus bisporus, Auriscalpium vulgare, Lepista nuda, Pleurotus ostreatus and Trametes versicolor were conducted. Through these investigations, the catalytic functions of 30 STSs were revealed using recombinant enzymes heterologously expressed in Saccharomyces cerevisiae. Furthermore, the unique function of an STS from P. ostreatus, PoSTS-06, was revealed to be the production of a novel sesquiterpene hydrocarbon that we named pleostene. The absolute structure of pleostene was determined by NMR spectroscopy and X-ray crystallography using the crystalline sponge method.

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Section: Introductionmentioning

confidence: 99%

Biocatalyst collection and heterologous expression of sesquiterpene synthases from basidiomycetous fungi: Discovery of a novel sesquiterpene hydrocarbon

Masunaga

Kitaoka

Ichinose

2022

Microbial Biotechnology

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Recent progress in the evaluation of secondary metabolites from Basidiomycota

Sum,

Ebada,

Clement Matasyoh

et al. 2023

Current Research in Biotechnology

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Sesquiterpenes from the Fungus Antrodiella albocinnamomea with Cytotoxicity and Antibacterial Activity

Ning

Liu

et al. 2023

JoF

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Eight new sesquiterpenes, namely, albocinnamins A−H (1−8), along with two known ones (9 and 10), have been isolated from the fungus Antrodiella albocinnamomea. Compound 1 possesses a new backbone that might be derived from cadinane-type sesquiterpene. Structures of the new compounds were elucidated by detailed spectroscopic data analysis, single-crystal X-ray diffraction, and ECD calculations. Compounds 1a and 1b showed cytotoxicity against SW480 and MCF-7 cells, with IC50 values ranging from 19.3 to 33.3 μM, while compound 2 displayed cytotoxicity against the HL-60 cell with an IC50 value of 12.3 μM. In addition, compounds 5 and 6 exhibited antibacterial activity against Staphylococcus aureus with MIC values of 64 and 64 µg/mL, respectively.

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A new chamigrane sesquiterpene from the basidiomycete Antrodiella albocinnamomea

Cited by 3 publications

References 15 publications

Biocatalyst collection and heterologous expression of sesquiterpene synthases from basidiomycetous fungi: Discovery of a novel sesquiterpene hydrocarbon

Biocatalyst collection and heterologous expression of sesquiterpene synthases from basidiomycetous fungi: Discovery of a novel sesquiterpene hydrocarbon

Recent progress in the evaluation of secondary metabolites from Basidiomycota

Sesquiterpenes from the Fungus Antrodiella albocinnamomea with Cytotoxicity and Antibacterial Activity

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