A new cerebroside from Gynura divaricata

Chen, Lei; Li, Houquan; Hong-tao, Song; Zhang, Guogang

doi:10.1016/j.fitote.2009.06.010

Cited by 21 publications

(17 citation statements)

References 3 publications

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“…Many other plants of the genus of Gynura were found to inhibit the key enzymes relevant to type 2 diabetes (including α-glucosidase and α-amylase) and hypertension and show anti-diabetic and hypoglycemic activities [6–14]. The chemical constituents of the genus of Gynura included flavonoid, phenolic acid, cerebrosides, polysaccharide, alkaloids, terpenoids and sterols [15–19]. Phenolic acid, flavonoid and polysaccharide were the major hypoglycemic active components of Gynura genus.…”

Section: Introductionmentioning

confidence: 99%

Yeast α-Glucosidase Inhibitory Phenolic Compounds Isolated from Gynura medica Leaf

Tan

Wang

Luo

et al. 2013

IJMS

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Gynura medica leaf extract contains significant amounts of flavonols and phenolic acids and exhibits powerful hypoglycemic activity against diabetic rats in vivo. However, the hypoglycemic active constituents that exist in the plant have not been fully elaborated. The purpose of this study is to isolate and elaborate the hypoglycemic activity compounds against inhibition the yeast α-glucosidase in vitro. Seven phenolic compounds including five flavonols and two phenolic acids were isolated from the leaf of G. medica. Their structures were identified by the extensive NMR and mass spectral analyses as: kaempferol (1), quercetin (2), kaempferol-3-O-β-D-glucopyranoside (3), kaempferol-3-O-rutinoside (4), rutin (5), chlorogenic acid (6) and 3,5-dicaffeoylquinic acid methyl ester (7). All of the compounds except 1 and 3 were isolated for the first time from G. medica. Compounds 1–7 were also assayed for their hypoglycemic activity against yeast α-glucosidase in vitro. All of the compounds except 1 and 6 showed good yeast α-glucosidase inhibitory activity with the IC50 values of 1.67 mg/mL, 1.46 mg/mL, 0.38 mg/mL, 0.10 mg/mL and 0.53 mg/mL, respectively.

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Section: Introductionmentioning

confidence: 99%

Yeast α-Glucosidase Inhibitory Phenolic Compounds Isolated from Gynura medica Leaf

Tan

Wang

Luo

et al. 2013

IJMS

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show abstract

“…The ethanol extract of G. medica had demonstrated hypoglycemic activity in animal models [16,17]. Many plants of the genus Gynura have been used for the treatment of bronchitis, pulmonary tuberculosis, pertussis, sore eyes, toothache, rheumatic arthralgia and diabetes in folk medicine [18]. They were also used as a nutriment vegetable by the local people in the southeast area of China.…”

Section: Introductionmentioning

confidence: 99%

“…They were also used as a nutriment vegetable by the local people in the southeast area of China. The chemical constituents of the genus Gynura include flavonoid, phenolic acid, cerebrosides, polysaccharide, alkaloids, terpenoids and sterols [18–21]. Phenolic acid and flavonoid are the major components of the Gynura genus.…”

Section: Introductionmentioning

confidence: 99%

Optimization of Total Flavonoid Compound Extraction from Gynura medica Leaf Using Response Surface Methodology and Chemical Composition Analysis

Liu

Yang

et al. 2010

IJMS

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Optimization of total flavonoid compound (TFC) extraction from Gynura medica leaf was investigated using response surface methodology (RSM) in this paper. The conditions investigated were 30–60% (v/v) ethanol concentration (X1), 85–95 °C extraction temperature (X2) and 30–50 (v/w) liquid-to-solid ratio (X3). Statistical analysis of the experiments indicated that temperature and liquid-to-solid ratio significantly affected TFC extraction (p < 0.01). The Box-Behnken experiment design showed that polynomial regression models were in good agreement with the experimental results, with the coefficients of determination of 0.9325 for TFC yield. The optimal conditions for maximum TFC yield were 55% ethanol, 92 °C and 50 (v/w) liquid-to-solid ratio with a 30 min extraction time. Extracts from these conditions showed a moderate antioxidant value of 54.78 μmol quercetin/g dry material (DM), 137.3 μmol trolox/g DM for 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 108.21 μmol quercetin/g DM, 242.31 μmol trolox/g DM for 2,2-azino-bis-(3-ethylbenzthiazoline-6-sulphonic acid) (ABTS+), respectively. HPLC-DAD-MS analysis showed that kaempferol-3-O-glucoside was the principal flavonoid compound in Gynura medica leaf.

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“…At present, reported techniques about purification and isolation of cerebroside molecular species are all traditionally adopted repeated normal/reverse-silica gel column chromatography 17,18 . To many chromatographic procedure results in wastage, low yield and long cycle, consequently restrict further research.…”

Section: Isolated Cerebrosides From Stichopus Varie-mentioning

confidence: 99%

Isolation of cytotoxic glucoerebrosides and long-chain bases from sea cucumber Cucumaria frondosa using high speed counter-current chromatography

Guo

et al. 2013

J. Oleo Sci.

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A new cerebroside from Gynura divaricata

Cited by 21 publications

References 3 publications

Yeast α-Glucosidase Inhibitory Phenolic Compounds Isolated from Gynura medica Leaf

Yeast α-Glucosidase Inhibitory Phenolic Compounds Isolated from Gynura medica Leaf

Optimization of Total Flavonoid Compound Extraction from Gynura medica Leaf Using Response Surface Methodology and Chemical Composition Analysis

Isolation of cytotoxic glucoerebrosides and long-chain bases from sea cucumber Cucumaria frondosa using high speed counter-current chromatography

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