“…For this research study, we were only considered undirected, loop-free connected graphs according to the PPIN topology. For centrality analysis, the following 27 centrality measures were selected: Average Distance [ 43 ], Barycenter [ 44 ], Closeness (Freeman) [ 9 ], Closeness (Latora) [ 45 ], Residual closeness [ 46 ], ClusterRank [ 47 ], Decay [ 48 ], Diffusion degree [ 49 ], Density of Maximum Neighborhood Component (DMNC) [ 50 ], Geodesic K-Path [ 51 , 52 ], Katz [ 53 , 54 ], Laplacian [ 55 ], Leverage [ 56 ], Lin [ 57 ], Lobby [ 58 ], Markov [ 59 ], Maximum Neighborhood Component (MNC) [ 50 ], Radiality [ 60 ], Eigenvector [ 61 ], Subgraph scores [ 62 ], Shortest-Paths betweenness [ 9 ], Eccentricity [ 63 ], Degree, Kleinberg’s authority scores [ 64 ], Kleinberg’s hub scores [ 64 ], Harary graph [ 63 ] and Information [ 65 ]. All these measures are calculated for undirected networks in a reasonable time.…”