An efficient approach to prepare
trifluoromethyl-α-carbolines
and ester group-substituted α-carbolines via the tandem cyclization
reaction of 2-(2-aminophenyl)acetonitriles and trifluoromethyl 1,3-diones
or β,γ-unsaturated α-ketoesters was reported. The
transformation proceeded smoothly in the presence of catalytic environmental-benign
iron salts, which are used to prepare the desired products in moderate
to good yields.