A new case of reciprocal translocation t(10;13)(q16;q21) diagnosed in an AI boar

Danielak-Czech, B.; Słota, E.

doi:10.1007/bf03195236

Cited by 4 publications

(2 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Tandem fusion occurs similarly to Robertsonian translocations; however, it instead involves the fusion of the telomeric region of one chromosome to the centromeric region of another. Tandem fusion is a rare event in the pig, with just one such rearrangement reported, 37, XY, der(14;17)(q29;q10) [ 58 ].…”

Section: Robertsonian Translocations and Tandem Fusionsmentioning

confidence: 99%

Classical, Molecular, and Genomic Cytogenetics of the Pig, a Clinical Perspective

Donaldson

Villagómez

King

2021

Animals

View full text Add to dashboard Cite

The chromosomes of the domestic pig (Sus scrofa domesticus) are known to be prone to reciprocal chromosome translocations and other balanced chromosome rearrangements with concomitant fertility impairment of carriers. In response to the remarkable prevalence of chromosome rearrangements in swine herds, clinical cytogenetics laboratories have been established in several countries in order to screen young boars for chromosome rearrangements prior to service. At present, clinical cytogenetics laboratories typically apply classical cytogenetics techniques such as giemsa-trypsin (GTG)-banding to produce high-quality karyotypes and reveal large-scale chromosome ectopic exchanges. Further refinements to clinical cytogenetics practices have led to the implementation of molecular cytogenetics techniques such as fluorescent in-situ hybridization (FISH), allowing for rearrangements to be visualized and breakpoints refined using fluorescently labelled painting probes. The next-generation of clinical cytogenetics include the implementation of DNA microarrays, and next-generation sequencing (NGS) technologies such as DNA sequencing to better explore tentative genome architecture changes. The implementation of these cytogenomics techniques allow the genomes of rearrangement carriers to be deciphered at the highest resolution, allowing rearrangements to be detected; breakpoints to be delineated; and, most importantly, potential gene implications of those chromosome rearrangements to be interrogated. Clinical cytogenetics has become an integral tool in the livestock industry, identifying rearrangements and allowing breeders to make informed breeding decisions.

show abstract

Section: Robertsonian Translocations and Tandem Fusionsmentioning

confidence: 99%

Classical, Molecular, and Genomic Cytogenetics of the Pig, a Clinical Perspective

Donaldson

Villagómez

King

2021

Animals

View full text Add to dashboard Cite

show abstract

“…The most prevalent type of structural rearrangements in pigs are reciprocal translocations, which are caused by the exchange of chromatid parts between two or more nonhomologous chromosomes. These heritable chromosomal mutations affect all autosomal chromosomes and sex chromosomes, and among almost 200 translocations that have been identified to date, no two identical cases have been found in unrelated animals [ 1 , 2 , 4 , 12 , 13 , 15 , 16 , 17 , 18 , 19 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 ]. The individual consequences of each translocation depend on the morphology of the chromosomes involved, size of the rearranged fragments, and location of centromere breakpoints and positions as factors determining the gametogenesis process (meiotic conjugation and segregation) and the proportion of aneuploid gametes produced (about 40% on average).…”

Section: Pig Karyotype Abnormalities and Their Effect On Carrier Fmentioning

confidence: 99%

Breeding and Economic Aspects of Cytogenetic Screening Studies of Pigs Qualified for Reproduction

Danielak-Czech

Kozubska‐Sobocińska

Smołucha

et al. 2020

Animals

Self Cite

View full text Add to dashboard Cite

Cytogenetic monitoring allows the identification and early removal of pigs affected by inherited karyotype defects from breeding herds. These abnormalities cause developmental anomalies, considerably reducing the fertility (by several dozen to 100%) and performance parameters of breeding herds, resulting in substantial financial losses. This mainly concerns reciprocal translocations, typical of pigs, which are highly prevalent (about 0.46%), generally occur de novo, and normally result in low breeding soundness of the carriers. Due to the potential spontaneous occurrence of chromosomal aberrations and the rapid spread of these genetic defects in the population, especially under artificial insemination conditions, it is necessary to perform routine karyotype screening of animals qualified for reproduction. The cytogenetic screening program for young boars, carried out using continually refined diagnostic techniques, permits a precise and reliable karyotype assessment, identification of chromosomal abnormalities, and formulation of specific selection guidelines.

show abstract

A High Incidence of Adjacent-1 Meiotic Segregation Pattern, Revealed by Multicolor Sperm FISH, in a Carrier Boar of a New Reciprocal Translocation t(6;16)(p13;q23)

Kociucka

Szczerbal

Bugaj

et al. 2013

Cytogenet Genome Res

View full text Add to dashboard Cite

Reciprocal translocations pose a serious problem in pig breeding due to the reduced fertility of the carriers. This paper presents a new reciprocal translocation in a phenotypically normal, but hypoprolific (20% reduction) boar. Chromosome banding as well as the FISH technique with the use of BAC and telomeric probes was applied for a detailed characterization of this chromosome rearrangement. The karyotype of the studied boar was described as 38,XY,t(6;16)(p13;q23). The meiotic segregation of the quadrivalent was studied in 1,071 sperms by multicolor FISH. The most frequent segregation patterns were alternate (47.5%) and adjacent 1 (41.9%), while adjacent 2 and 3:1 were less frequent at 1.2 and 9.2%, respectively. Surprisingly, the frequency of the adjacent-1 segregation appeared to be relatively high, when compared with human and pig reciprocal translocations studied by sperm FISH. Our study, along with a review of the literature, shows that a reduction of fertility in the carriers and the incidence of different segregation patterns of the quadrivalent may vary within a broad range, and both aspects seem to be unrelated. A need for obligatory karyotype screening programs of artificial insemination boars is emphasized.

show abstract

A new case of reciprocal translocation t(10;13)(q16;q21) diagnosed in an AI boar

Cited by 4 publications

References 17 publications

Classical, Molecular, and Genomic Cytogenetics of the Pig, a Clinical Perspective

Classical, Molecular, and Genomic Cytogenetics of the Pig, a Clinical Perspective

Breeding and Economic Aspects of Cytogenetic Screening Studies of Pigs Qualified for Reproduction

A High Incidence of Adjacent-1 Meiotic Segregation Pattern, Revealed by Multicolor Sperm FISH, in a Carrier Boar of a New Reciprocal Translocation t(6;16)(p13;q23)

Contact Info

Product

Resources

About