A new case of cutaneous infection by a presumed monoxenous trypanosomatid in the island of Martinique (French West Indies)

Boisseau‐Garsaud, Anne‐Marie; Calès-Quist, D.; Desbois, N.; Jouannelle, J.; Jouannelle, A; Pratlong, Francine; Dedet, Jean-Pierre

doi:10.1016/s0035-9203(00)90435-8

Cited by 43 publications

(36 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A second case report, also from Martinique, identified the same organism as that described above for the previous Martinique case as being the cause of a localized cutaneous lesion in an ICT patient (54). The patient was treated with pentamidine, and the lesion disappeared within 2 months.…”

Section: Lower Trypanosomatidsmentioning

confidence: 57%

“…The prospect of parasitological cure for patients infected with lower trypanosomatids appears to be quite good, even in the presence of HIV. In all of these cases, patients presented with symptoms similar to those observed for the common Leishmania syndromes and responded well to antimonial treatment or pentamidine in one case (54). Therefore, in cases where infection with lower trypanosomatids is misdiagnosed as leishmaniasis and treated as such, therapy is likely to be successful.…”

Section: Lower Trypanosomatidsmentioning

confidence: 81%

See 1 more Smart Citation

Importance of Nonenteric Protozoan Infections in Immunocompromised People

et al. 2010

View full text Add to dashboard Cite

SUMMARY There are many neglected nonenteric protozoa able to cause serious morbidity and mortality in humans, particularly in the developing world. Diseases caused by certain protozoa are often more severe in the presence of HIV. While information regarding neglected tropical diseases caused by trypanosomatids and Plasmodium is abundant, these protozoa are often not a first consideration in Western countries where they are not endemic. As such, diagnostics may not be available in these regions. Due to global travel and immigration, this has become an increasing problem. Inversely, in certain parts of the world (particularly sub-Saharan Africa), the HIV problem is so severe that diseases like microsporidiosis and toxoplasmosis are common. In Western countries, due to the availability of highly active antiretroviral therapy (HAART), these diseases are infrequently encountered. While free-living amoebae are rarely encountered in a clinical setting, when infections do occur, they are often fatal. Rapid diagnosis and treatment are essential to the survival of patients infected with these organisms. This paper reviews information on the diagnosis and treatment of nonenteric protozoal diseases in immunocompromised people, with a focus on patients infected with HIV. The nonenteric microsporidia, some trypanosomatids, Toxoplasma spp., Neospora spp., some free-living amoebae, Plasmodium spp., and Babesia spp. are discussed.

show abstract

Section: Lower Trypanosomatidsmentioning

confidence: 57%

Section: Lower Trypanosomatidsmentioning

confidence: 81%

Importance of Nonenteric Protozoan Infections in Immunocompromised People

et al. 2010

View full text Add to dashboard Cite

show abstract

“…However, in some cases, nonhuman monoxenous trypanosomatids have been isolated from HIV-positive patients, mimicing both VL (121,180) and CL (40,75,227). These infections suggest that the immunocompromised patient could be vulnerable to other currently non-human-pathogenic trypanosomatids due to their anergic status (58,74).…”

Section: Other Leishmania Species During Hiv Coinfectionmentioning

confidence: 99%

The Relationship between Leishmaniasis and AIDS: the Second 10 Years

et al. 2008

View full text Add to dashboard Cite

SUMMARY To date, most Leishmania and human immunodeficiency virus (HIV) coinfection cases reported to WHO come from Southern Europe. Up to the year 2001, nearly 2,000 cases of coinfection were identified, of which 90% were from Spain, Italy, France, and Portugal. However, these figures are misleading because they do not account for the large proportion of cases in many African and Asian countries that are missed due to a lack of diagnostic facilities and poor reporting systems. Most cases of coinfection in the Americas are reported in Brazil, where the incidence of leishmaniasis has spread in recent years due to overlap with major areas of HIV transmission. In some areas of Africa, the number of coinfection cases has increased dramatically due to social phenomena such as mass migration and wars. In northwest Ethiopia, up to 30% of all visceral leishmaniasis patients are also infected with HIV. In Asia, coinfections are increasingly being reported in India, which also has the highest global burden of leishmaniasis and a high rate of resistance to antimonial drugs. Based on the previous experience of 20 years of coinfection in Europe, this review focuses on the management of Leishmania-HIV-coinfected patients in low-income countries where leishmaniasis is endemic.

show abstract

“…Monoxenous trypanosomatids had never been confirmed as pathogenic in vertebrate host. However, there is one report of trypanosomatid, other than Trypanosoma and Leishmania, in some opportunistic cutaneous infections in immunocompromised individuals [3] or those without any previous history of immunodepression [4]. In addition, our group was pioneer in proving the infection of mouse dermal fibroblasts by two different monoxenous trypanosomatid species-Crithidia deanei and Herpetomonas roitmani [5].…”

Section: Introductionmentioning

confidence: 99%