A New Carbazole Alkaloid from Murraya koenigii Spreng (Rutaceae)

Abstract

A new carbazole alkaloid (kurryam) oxygenated at the 4-position, hitherto unknown among carbazole alkaloids, has been isolated from the seeds of an Indian medicinal plant, Murraya koenigii (Rutaceae). The structure has been established as 4-hydroxy-(2′,2′,3)-trimethyl-(6,7)-dimethoxy pyranocarbazole from extensive 2D NMR spectral studies. In addition, two known carbazole alkaloids, (2′,2′,3)-trimethyl 6-methoxy pyranocarbazole and (2′,2′,3)-trimethyl 6-hydroxy pyranocarbazole were isolated from the seeds of the same plant, of which (2′,2′,3)-trimethyl 6-methoxy pyranocarbazole exhibited significant antidiarrhoeal activity, as also did the new compound.

Diversity of Mushrooms and Their Metabolites of Nutraceutical and Therapeutic Significance

“…Alkaloids have been reported in curing many deadly human diseases like AIDS, cancer, and lung diseases [113]. Alkaloids regulate Na + ions and channels and microbial activity, have stimulating properties, and induce immunogenic cell death.…”

A New Chalcone from Pongamia Pinnata and its Antioxidant Properties

“…Experimental Instruments: The instruments used for the measurement of melting points, UV, NMR and mass spectra were reported in our earlier publication [3].…”

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“…Experimental Instruments: The instruments used for the measurement of melting points, UV, NMR and mass spectra were reported in our earlier publications [4].…”