A new carbapenem drug dosage metric for carbapenem usage and correlation with carbapenem resistance of Pseudomonas aeruginosa

Hirayama, S.; Yasui, Kumiko; Murakami, Hiroatsu; Kosugi, Tadayoshi; Sakamoto, Maki; Hanai, Yuki; Matsuo, Kazuhiro; Miyazaki, Taito; Ishii, Yoshikazu; Nishizawa, Kenji; Tateda, Kazuhiro

doi:10.1016/j.jiac.2018.08.001

Cited by 4 publications

(11 citation statements)

References 27 publications

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“…Schroeder et al [16] has detailed the mechanism of antibiotic resistance previously. A meta-analysis has revealed that antibiotic usage can lead to the resistance mutation, even in animal husbandry where there is a positive association between bacterial resistance and antibiotic consumption in farm animals [23–26] . Interestingly, in this study, our statistical analysis showed that the irregular use of imipenem in 2012 to 2013 (Table 3) had a delayed, rather than immediate effect in causing the sudden increase of CRKp which occurred in 2014 and then gradually decreased (Fig.…”

Section: Discussionmentioning

confidence: 57%

Factors behind the prevalence of carbapenem-resistant Klebsiella pneumoniae in pediatric wards

Yang

Liu²,

Muhammad

et al. 2021

Medicine

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The emergence of carbapenem-resistant Enterobacteriaceae made the treatment difficult, which has become a significant issue of public health. A sharp increase of carbapenem-resistance rate in Klebsiella pneumoniae was observed in a maternity and child health care hospital in Zunyi, China, in 2014. In 2015 to 2016, carbapenem-resistant Klebsiella pneumoniae (CRKp) isolated from all the clinical samples were analyzed to identify the carbapenem-resistance genes. They were then fingerprinted in order to determine their genetic relationship. Clinical data such as usage of imipenem in 2012 to 2016 and the nosocomial infection surveillance data were analyzed. Thirty-five isolates of CRKp out of 4328 various pathogens were obtained, and bla NDM-1 was identified to be the most common resistant gene present in the CRKp isolates. The fingerprint analysis identified 15 major clusters of CRKp isolates. The bacteria with close proximity relationship tended to be from the same wards. However, a few CRKp isolates from different wards were found to be genetically highly related. The clinical data showed a significantly higher usage of carbapenems in 2012 to 2013 before the CRKp rate sharply increased in 2014. The nosocomial infection surveillance showed an unexpectedly high rate of failures to meet the requirement of the hospital environment hygiene and hand hygiene in the neonatal ward. The increasing isolation rate of CRKp was associated with poorly regulated usage of carbapenems, impropriate medical practices, and the poor hospital environmental hygiene and hand hygiene.

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Section: Discussionmentioning

confidence: 57%

Factors behind the prevalence of carbapenem-resistant Klebsiella pneumoniae in pediatric wards

Yang

Liu²,

Muhammad

et al. 2021

Medicine

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“…Overall, 58 articles [ 20 – 77 ] published globally from 2016 to 2022 were included in the systematic review. The summary of articles included, including the correlation between bacterial resistance and ABC, is summarized and annexed in Annex 1 .…”

Section: Resultsmentioning

confidence: 99%

“…The majority of the articles 13 (22.3%) were published in China [ 21 , 25 – 28 , 42 , 60 , 62 – 64 , 68 , 72 , 77 ], 4 (6.9%) Europe [ 48 , 49 , 74 , 75 ], 4 (6.9%) South Korea [ 31 , 54 , 61 , 65 ], 4 (6.9%) Serbia [ 34 , 36 , 39 , 52 ], 3 (5.2%) Japan [ 20 , 30 , 40 ], 2 (3.4%) Italy [ 22 , 33 ], 2 (3.4%) Thailand [ 35 , 57 ], 2 (3.4%) France [ 46 , 56 ], 2 (3.4%) Spain [ 43 , 59 ], 2 (3.4%) Slovenia [ 47 , 71 ], 2 (3.4%) Switzerland [ 45 , 70 ], and the rest were in different countries [ 23 , 29 , 32 , 37 , 38 , 41 , 44 , 50 , 51 , 53 , 55 , 58 , 66 , 67 , 69 , 73 , 76 , 77 ]. The majority of the articles 11(23.4%) were published in 2017 [ 22 , 33 , 36 , 44 , 47 , 48 , 52 , 56 , 59 , 64 , 67 ], 2018 […”

Section: Resultsmentioning

confidence: 99%

Relationship between Antibiotic Consumption and Resistance: A Systematic Review

Abejew,

Wubetu,

Fenta

2024

Canadian Journal of Infectious Diseases and Medical Microbiolog

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Background. Unreserved use of antibiotics exerted selective pressure on susceptible bacteria, resulting in the survival of resistant strains. Despite this, the relationship between antibiotic resistance (ABR) and antibiotic consumption (ABC) is rarely studied. This systematic review aims to review the relationship between ABC and ABR from 2016 to 2022. Methods. Articles published over 7 years (2016–2022) were searched from December 23 to 31, 2022. The search strategy was developed by using keywords for ABC and ABR. From 3367 articles, 58 eligible articles were included in the final review. Results. The pooled ABC was 948017.9 DPDs and 4108.6 DIDs where over 70% of antibiotics were from the Watch and Reserve category based on the WHO AWaRe classification. The average pooled prevalence of ABR was 38.4%. Enterococcus faecium (59.4%), A. baumannii (52.6%), and P. aeruginosa (48.6%) were the most common antibiotic-resistant bacteria. Cephalosporins (76.8%), penicillin (58.3%), and aminoglycosides (52%) were commonly involved antibiotics in ABR. The positive correlation between ABR and consumption accounted for 311 (81%). The correlation between ABR P. aeruginosa and ABC accounted for 87 (22.7%), followed by 78 (20.3%) and 77 (20.1%) for ABR E. coli and K. pneumoniae with ABCs, respectively. Consumption of carbapenems and fluoroquinolones was most commonly correlated with resistance rates of P. aeruginosa, K. pneumoniae, E. coli, and A. baumannii. Conclusion. There is a positive correlation between ABC and the rate of ABR. The review also revealed a cross-resistance between the consumption of different antibiotics and ABR. Optimizing antibiotic therapy and reducing unnecessary ABC will prevent the emergence and spread of ABR. Thus, advocating the implementation of stewardship programs plays a pivotal role in containing ABR.

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“…Schroeder JW has detailed the mechanism of antibiotic resistance previously [14]. A meta-Analysis has revealed that antibiotic usage can lead to resistance mutation, even in animal husbandry where there is a positive association between bacterial resistance and antibiotic consumption in farm animals [21,22,23,24].…”

Section: Discussionmentioning

confidence: 99%

A possible link between improper use of carbapenems and prevalence of carbapenem-resistant Klebsiella Pneumoniae in a hospital

Chai

Yang²,

Liu

et al. 2020

Preprint

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Background: The emergence of carbapenem-resistant Enterobacteriaceae made the treatment difficult, which has become a major issue of public health. A sharp increase of carbapenem-resistance rate in Klebsiella pneumoniae was observed in a maternity and child health care hospital in Zunyi, China, in 2014.To investigate the cause and epidemiology of the carbapenem-resistant Klebsiella pneumoniae (CRKp) in the affected hospital.Methods: In 2015-2016, CRKp isolated from all the clinical samples were analyzed to identify the carbapenem-resistance genes. They were then fingerprinted in order to determine their genetic relationship. Clinical data such as usage of imipenem in 2012-2016 and the nosocomial infection surveillance data were analyzedResults: Thirty five isolates of CRKp out of 4328 various pathogens were obtained and blaNDM-1 was identified to be the most common resistant gene present in the CRKp isolates. The fingerprint analysis identified 15 major clusters of CRKp isolates. The bacteria with close proximity relationship tended to be from the same wards. However, a few CRKp isolates from different wards were found to be genetically highly related. The clinical data showed a significantly higher usage of carbapenems in 2012-2013, before the CRKp rate sharply increased in 2014. The nosocomial infection surveillance showed unexpected high rate of failures to meet the requirement of the hospital environment hygiene and hand hygiene in the neonatal ward.Conclusion: The increasing isolation rate of CRKp was associated with poorly regulated usage of carbapenems, impropriate medical practices and the poor hospital environmental hygiene and hand hygiene.

show abstract

A new carbapenem drug dosage metric for carbapenem usage and correlation with carbapenem resistance of Pseudomonas aeruginosa

Cited by 4 publications

References 27 publications

Factors behind the prevalence of carbapenem-resistant Klebsiella pneumoniae in pediatric wards

Factors behind the prevalence of carbapenem-resistant Klebsiella pneumoniae in pediatric wards

Relationship between Antibiotic Consumption and Resistance: A Systematic Review

A possible link between improper use of carbapenems and prevalence of carbapenem-resistant Klebsiella Pneumoniae in a hospital

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