A New Capillary Electrophoresis Device with Deep UV Detector Based on LED Technology

Rohrbasser, Claude; Rhème, D.; Décastel, Sylvain; Roth, S.; Montes, Maria de Lourdes Aja; Veuthey, Jean‐Luc; Rudaz, Serge

doi:10.2533/chimia.2009.890

Cited by 9 publications

(6 citation statements)

References 4 publications

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“…Due to the utilization of an early low intensity UV-LED a photomultiplier tube was employed to measure the light intensity. Rudaz and coworkers in 2009 also reported a UV-LED based detector for CE, but no details on the design of the detector nor its performance parameters were given [18,19]. The detector reported herein was fitted with newer LEDs of higher intensity than previously available and is based on photodiodes.…”

Section: Introductionmentioning

confidence: 99%

Absorbance detector for capillary electrophoresis based on light-emitting diodes and photodiodes for the deep-ultraviolet range

Bui

Hauser

2015

Journal of Chromatography A

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Section: Introductionmentioning

confidence: 99%

Absorbance detector for capillary electrophoresis based on light-emitting diodes and photodiodes for the deep-ultraviolet range

Bui

Hauser

2015

Journal of Chromatography A

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“…Since CE presents the distinct advantage of reduced operating cost and low-cost CE instruments have been implemented in several developing countries [14,15] for the quality control of drugs and detection of counterfeit or substandard formulations, the possibility of using this technique for the assay of AL in FDCs formulations is investigated in this paper.…”

Section: Introductionmentioning

confidence: 99%

Determination of artemether and lumefantrine in anti-malarial fixed-dose combination tablets by microemulsion electrokinetic chromatography with short-end injection procedure

Amin

Fabre

Blanchin

et al. 2013

Malar J

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BackgroundArtemether-lumefantrine (AL) combination therapy is now the most used anti-malarial treatment in the world. Quality control of AL formulations is still a major challenge in developing countries. Until now, only liquid chromatographic methods have been reported in the literature for their analysis. Capillary electrophoretic methods, which present various advantages (low price of capillary, low volumes of electrolyte consumption), may be an alternative to liquid chromatography methods. In this paper, a reliable method was developed and validated for the determination of AL in commercial fixed-dose combination tablets commercialized in Côte d’Ivoire.MethodsArtemether and lumefantrine were determined by microemulsion electrokinetic chromatography using short-end injection procedure. The two analytes were extracted from tablets by acidified methanol. Pyrimethamine was used as internal standard. Separation was carried out in an uncoated fused silica capillary, 30 cm long × 50 μm internal diameter, using an effective length of 10 cm and a microemulsion composed of octane, butanol, sodium dodecyl sulfate and borate buffer as background electrolyte, a - 500 V.cm-1 electric field and a detection wavelength of 214 nm.ResultsArtemether, lumefantrine and pyrimethamine were separated in 6 min. The method was reliable with respect to selectivity towards formulation excipients, linearity of the response function (r2 > 0.998), recovery studies from synthetic tablets (in the range 99–101%), repeatability (relative standard deviation 1–3%, n = 7 analytical procedures). Application to four commercial formulations containing 20/120 mg of AL per tablet gave a content in good agreement with the declared content. However, the electropherogram of one tablet formulation showed the presence of an ingredient which was not declared.ConclusionThe developed MEEKC method can be proposed as an alternative method to liquid chromatography for the determination of artemether and lumefantrine in fixed-dose combination tablet formulations.

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“…This field of research started about ten years ago with the construction of a budget capillary electrophoresis (ECB) designed for the detection of counterfeit medicines. [25] Building on this experience, the team is now developing a new generation of capillary electrophoresis instrument based on the open-source hardware principle, and looking for new applications for this technology.…”

Section: Analytical Chemistry Randdmentioning

confidence: 99%

Analytical Platforms at Swiss Universities of Applied Sciences

Berchtold

Bourgeois

Christen

et al. 2020

Chimia

Self Cite

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Numerous projects and industrial and academic collaborations benefit from state-of-the-art facilities and expertise in analytical chemistry available at the Swiss Universities of Applied Sciences. This review summarizes areas of expertise in analytical sciences at the University of Applied Sciences and Arts Northwestern Switzerland (FHNW), the University of Applied Sciences and Arts Western Switzerland (HES-SO), and the Zurich University of Applied Sciences (ZHAW). We briefly discuss selected projects in different fields of analytical sciences

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A New Capillary Electrophoresis Device with Deep UV Detector Based on LED Technology

Cited by 9 publications

References 4 publications

Absorbance detector for capillary electrophoresis based on light-emitting diodes and photodiodes for the deep-ultraviolet range

Absorbance detector for capillary electrophoresis based on light-emitting diodes and photodiodes for the deep-ultraviolet range

Determination of artemether and lumefantrine in anti-malarial fixed-dose combination tablets by microemulsion electrokinetic chromatography with short-end injection procedure

Analytical Platforms at Swiss Universities of Applied Sciences

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