A new candidate epitope-based vaccine against PspA PhtD of Streptococcus pneumoniae: a computational experimental approach
Mona Shafaghi,
Zohreh Bahadori,
Seyed Mahmoud Barzi
et al.
Abstract:IntroductionPneumococcus is an important respiratory pathogen that is associated with high rates of death in newborn children and the elderly. Given the disadvantages of current polysaccharide-based vaccines, the most promising alternative for developing improved vaccines may be to use protein antigens with different roles in pneumococcus virulence. PspA and PhtD, highly immunogenic surface proteins expressed by almost all pneumococcal strains, are capable of eliciting protective immunity against lethal infect… Show more
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