A New Calcitonin-Receptor-like Sequence in Rat Pulmonary Blood Vessels

Njuki, Frederick; Nicholl, Claire; Howard, Alison; Mak, Judith C.W.; Barnes, Peter J.; Girgis, S. I.; Legon, S.

doi:10.1042/cs0850385

Cited by 132 publications

(55 citation statements)

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“…This receptor was originally cloned as an orphan receptor member of the seventransmembrane domain G protein-linked receptor family and named calcitonin receptor-like receptor (CRLR) [48,49]. Subsequently, it was identified as the CGRP receptor [50].…”

Section: Discussionmentioning

confidence: 99%

Calcitonin-gene related peptide (CGRP) inhibits interleukin-7-induced pre-B cell colony formation

Fernandez

Knopf

McGillis

2000

Journal of Leukocyte Biology

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Calcitonin gene-related peptide (CGRP) is a sensory neuropeptide with inflammatory and immunoregulatory activities. Its role in B lymphocyte development was investigated using a pre-B cell colony-forming assay. Physiological concentrations of CGRP inhibited pre-B cell responses to interleukin-7 (IL-7). Inhibition was specific in that it was blocked by the CGRP antagonist CGRP 8-37 . Adrenomedulin, substance P, and calcitonin had no

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Section: Discussionmentioning

confidence: 99%

Calcitonin-gene related peptide (CGRP) inhibits interleukin-7-induced pre-B cell colony formation

Fernandez

Knopf

McGillis

2000

Journal of Leukocyte Biology

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“…However this work has been dicult to reproduce (Kennedy et al, 1998). Recent evidence suggests that both adrenomedullin and CGRP bind to the same seven transmembrane domain receptor, the calcitonin receptor-like receptor (CRLR, Njuki et al, 1993;Fluhmann et al, 1995). Interestingly, the speci®city of CRLR for these peptides is conferred by a novel family of single transmembrane proteins, termed receptor-activity modifying proteins (RAMPs, McLatchie et al, 1998).…”

Section: Introductionmentioning

confidence: 99%

Comparison of the expression of calcitonin receptor‐like receptor (CRLR) and receptor activity modifying proteins (RAMPs) with CGRP and adrenomedullin binding in cell lines

Choksi

Hay

Legon

et al. 2002

British J Pharmacology

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1 The calcitonin receptor-like receptor (CRLR) and speci®c receptor activity modifying proteins (RAMPs) together form receptors for calcitonin gene-related peptide (CGRP) and/or adrenomedullin in transfected cells. 2 There is less evidence that innate CGRP and adrenomedullin receptors are formed by CRLR/ RAMP combinations. We therefore examined whether CGRP and/or adrenomedullin binding correlated with CRLR and RAMP mRNA expression in human and rat cell lines known to express these receptors. Speci®c human or rat CRLR antibodies were used to examine the presence of CRLR in these cells. 3 We con®rmed CGRP subtype 1 receptor (CGRP 1 ) pharmacology in SK-N-MC neuroblastoma cells. L6 myoblast cells expressed both CGRP 1 and adrenomedullin receptors whereas Rat-2 ®broblasts expressed only adrenomedullin receptors. In contrast we could not con®rm CGRP 2 receptor pharmacology for Col-29 colonic epithelial cells, which, instead were CGRP 1 -like in this study.

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“…Une régulation post-transcriptionnelle par la progesté-rone, augmentant la sensibilité au CGRP, a été décrite dans le myomètre de souris [13]. Le CRLR, identifié en 1993, est un RCPG [14] possédant 55% d'identité avec le CTR. On sait maintenant qu'il peut à la fois être un récepteur du CGRP et de l'ADM, selon la molécule RAMP qui lui est associée [8] (Figure 1).…”

Section: Les Récepteurs Du Cgrp Et De L'admunclassified

RAMP et récepteurs couplés aux protéines G

Cueille

Garel

2004

Med Sci (Paris)

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Le fonctionnement des récepteurs couplés aux protéines G (RCPG) est connu depuis des décennies, mais un pas important a été franchi récemment, lorsqu'il a été montré que le caractère fonctionnel de certains récepteurs dépendait d'interactions protéiques de nature différente. Le rôle de ces interactions dans la localisation des RCPG et la transduction du signal a fait l'objet d'une revue récente [1]. En 1998, la découverte des RAMP (receptor activity-modifying protein), que l'on peut considérer comme des chaperons moléculaires pour les récepteurs du CGRP (calcitonin gene-related peptide) et de l'adrénomédulline (ADM), a modifié notre conception du fonctionnement des RCPG. L'interaction des RAMP avec les RCPG n'est observée, à ce jour, que dans le cas des récepteurs de classe II, c'est-à-dire des récepteurs de la calcitonine (CTR), de l'hormone parathyroïdienne (RPTH), du glucagon et du VIP/PACAP ou R-VPAC1. Les récepteurs du CGRP et de l'ADM

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A New Calcitonin-Receptor-like Sequence in Rat Pulmonary Blood Vessels

Cited by 132 publications

References 0 publications

Calcitonin-gene related peptide (CGRP) inhibits interleukin-7-induced pre-B cell colony formation

Calcitonin-gene related peptide (CGRP) inhibits interleukin-7-induced pre-B cell colony formation

Comparison of the expression of calcitonin receptor‐like receptor (CRLR) and receptor activity modifying proteins (RAMPs) with CGRP and adrenomedullin binding in cell lines

RAMP et récepteurs couplés aux protéines G

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