A New Bitterness Evaluation Index Obtained Using the Taste Sensor for 48 Active Pharmaceutical Ingredients of Pediatric Medicines

Kojima, Honami; Kurihara, Toshio; Yoshida, Miyako; Haraguchi, Tamami; Nishikawa, Haruka; Ikegami, Saeri; Okuno, Takayoshi; Yamashita, Takahiro; Nishikawa, J; Tsujino, Hirofumi; Arisawa, Mitsuhiro; Habara, Masaaki; Ikezaki, Hidekazu; Uchida, Takahiro

doi:10.1248/cpb.c20-01014

Cited by 9 publications

(10 citation statements)

References 38 publications

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“…CPZ is widely used in patients with schizophrenia and is only available in the form of tablets for adults; it is administered to children in its crushed form [22]. HPD is a drug typically used for the treatment of schizophrenia; its bitterness was confirmed in our previous study [16]. RIS is a second generation drug used for the treatment of schizophrenia and autism spectrum disorders [23], with very low solubility (44.74 mg/L at 25˚C) [24].…”

Section: Introductionmentioning

confidence: 68%

“…We have previously focused on the quantitative evaluation of the bitterness range of medicine formulations using an electrical tongue as a taste sensor [11] [12] [13] [14] [15]. In our previous studies [16] [17] [18], we confirmed the bitterness of some antipsychotic medicines, such as amitriptyline hydrochloride (AMT), chlorpromazine hydrochloride (CPZ) and haloperidol (HPD).…”

Section: Introductionmentioning

confidence: 82%

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Inhibitory Effect of 5-Adenylic Acid on Bitter Taste of Antipsychotic Drugs

Kawahara¹,

Uno²,

Kojima³

et al. 2022

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The purpose of the present study was to examine the effect of adenylic acid (adenosine 5-monophosphate; AMP), a known nutritional enhancer, on inhibiting the bitterness of antipsychotic medicines administered to patients with mental illnesses, including children. First, we chose four antipsychotic medicines, amitriptyline hydrochloride (AMT), chlorpromazine hydrochloride (CPZ), haloperidol (HPD) and risperidone (RIS) and evaluated the inhibition of their bitterness by AMP through taste sensor measurements. AMP showed a significant bitterness inhibition effect on all drugs. Second, MarvinSketch analysis revealed the potential formation of electrostatic interactions between ionic forms (IV) of AMP and ionic (cationic) forms of each drug, which resulted in bitterness suppression. Third, chemical shift perturbations in 1 H-NMR studies suggested an interaction between the phosphate group of AMP and amino group of AMT, CPZ, HPD and RIS. Last, conventional elution experiments of up to 1 min simulating oral cavity conditions were performed for 1 whole AMT tablet, half AMT tablet, crushed half AMT tablet, and crushed AMT tablet containing AMP powder/solution (1, 3 mM potency). The taste sensor output values of the crushed AMT tablet containing AMP powder/solution (1, 3 mM potency) were significantly lower than those of the crushed tablet.

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Section: Introductionmentioning

confidence: 68%

Section: Introductionmentioning

confidence: 82%

Inhibitory Effect of 5-Adenylic Acid on Bitter Taste of Antipsychotic Drugs

Kawahara¹,

Uno²,

Kojima³

et al. 2022

Self Cite

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“…Ideally, measures for slope control limits should be identified. This becomes of particular interest with regard to the findings of [68], who discussed the change in concentration-dependent potential, defined as the dose-response slope of the sensor outputs, as a useful bitterness evaluation index.…”

Section: Analytical Performance Qualificationmentioning

confidence: 99%

Critical View on the Qualification of Electronic Tongues Regarding Their Performance in the Development of Peroral Drug Formulations with Bitter Ingredients

Steiner,

Meyer,

Immohr

et al. 2024

Pharmaceutics

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In this review, we aim to highlight the advantages, challenges, and limitations of electronic tongues (e-tongues) in pharmaceutical drug development. The authors, therefore, critically evaluated the performance of e-tongues regarding their qualification to assess peroral formulations containing bitter active pharmaceutical ingredients. A literature search using the keywords ‘electronic’, ‘tongue’, ‘bitter’, and ‘drug’ in a Web of Science search was therefore initially conducted. Reviewing the publications of the past decade, and further literature where necessary, allowed the authors to discuss whether and how e-tongues perform as expected and whether they have the potential to become a standard tool in drug development. Specifically highlighted are the expectations an e-tongue should meet. Further, a brief insight into the technologies of the utilized e-tongues is given. Reliable protocols were found that enable (i) the qualified performance of e-tongue instruments from an analytical perspective, (ii) proper taste-masking assessments, and (iii) under certain circumstances, the evaluation of bitterness.

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“…Toko's group at Kyushu University, Japan, developed taste sensors that use lipid polymer membranes and have been employed to measure the taste of foods and pharmaceuticals. [1][2][3][4][5][6][7] The taste sensor can group taste substances to some extent based on their hydrophobicity and electric charge. Toko's group has achieved global selectivity to taste substances by altering the hydrophobicity and electric charge of the lipid polymer membrane.…”

Section: Introductionmentioning

confidence: 99%

Development of a microfluidic-based taste sensor using lipid polymer membrane

Tahara

SASSA

Takigawa

et al. 2023

Jpn. J. Appl. Phys.

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This study aims to develop a microfluidic-based taste sensor for detecting time-dependent human taste sensations. Lipid polymer membranes were welded to perforated polycarbonate films with organic solvents to monitor the adsorption and desorption of taste substances to lipid polymer membranes and to physically immobilize lipid polymer membranes to withstand the pressure of a pumped liquid. A polydimethylsiloxane (PDMS) flow channel was bonded chemically to the polycarbonate film with the lipid polymer membrane using 3-aminopropylethoxysilane. A fabricated microfluidic-based taste sensor could measure the membrane potential change with time due to the adsorption and desorption of tannic acid, an astringency substance, onto a lipid polymer membrane. The proposed sensor could be useful as a tool for assessing the time-course changes in human taste.

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A New Bitterness Evaluation Index Obtained Using the Taste Sensor for 48 Active Pharmaceutical Ingredients of Pediatric Medicines

Cited by 9 publications

References 38 publications

Inhibitory Effect of 5-Adenylic Acid on Bitter Taste of Antipsychotic Drugs

Inhibitory Effect of 5-Adenylic Acid on Bitter Taste of Antipsychotic Drugs

Critical View on the Qualification of Electronic Tongues Regarding Their Performance in the Development of Peroral Drug Formulations with Bitter Ingredients

Development of a microfluidic-based taste sensor using lipid polymer membrane

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