A new biosensor based on PVDF film for detection of nucleic acids

Zhao, Bei; Hu, Jie; Ren, Wei; Xu, Feng; Wu, Xiumei; Shi, Peng; Ye, Zuo‐Guang

doi:10.1016/j.ceramint.2015.03.253

Cited by 23 publications

(20 citation statements)

References 15 publications

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“…Their piezoelectric diaphragm biosensors were based on PZT films and had smaller dimensions, which could increase the mass sensitivity. Zhao et al [ 29 ] reported a lead-free piezoelectric biosensor based on polyvinylidene fluoride (PVDF) piezoelectric film with mass sensitivity of 185 Hz/μg, which was much smaller than our result.…”

Section: Resultscontrasting

confidence: 86%

“…Piezoelectric biosensors are mass-sensitive which is detected by measuring the shift of resonant frequency of the devices [ 25 , 28 ]. When the reaction between the recognition layer immobilized on the diaphragm and the captured target biological species happens, the total mass of the piezoelectric film area will change which results in a corresponding resonant frequency shift [ 29 ].…”

Section: Introductionmentioning

confidence: 99%

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Lead-Free Piezoelectric Diaphragm Biosensors Based on Micro-Machining Technology and Chemical Solution Deposition

Shi

et al. 2016

Sensors

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In this paper, we present a new approach to the fabrication of integrated silicon-based piezoelectric diaphragm-type biosensors by using sodium potassium niobate-silver niobate (0.82KNN-0.18AN) composite lead-free thin film as the piezoelectric layer. The piezoelectric diaphragms were designed and fabricated by micro-machining technology and chemical solution deposition. The fabricated device was very sensitive to the mass changes caused by various targets attached on the surface of diaphragm. The measured mass sensitivity value was about 931 Hz/μg. Its good performance shows that the piezoelectric diaphragm biosensor can be used as a cost-effective platform for nucleic acid testing.

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Section: Resultscontrasting

confidence: 86%

Section: Introductionmentioning

confidence: 99%

Lead-Free Piezoelectric Diaphragm Biosensors Based on Micro-Machining Technology and Chemical Solution Deposition

Shi

et al. 2016

Sensors

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“…The antibody in serum can be effectively adsorbed by the immobilized DNA, performing antibody detection. Similarly, nucleic acid sensors based on PVDF [164] have been developed. In the experiment, they used the hybridization between the capture probe and target analyte (Figure 13d) [164] and found that the mass load on the membrane was proportional to the quantity of target nucleic acids (Figure 13e) [164].…”

Section: Biosensor and Bionic Actuator Based On Piezoelectric Polymermentioning

confidence: 99%

Composites, Fabrication and Application of Polyvinylidene Fluoride for Flexible Electromechanical Devices: A Review

Guo

Duan

Xie

et al. 2020

Preprint

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The technological development of piezoelectric materials is crucial for developing wearable and flexible electromechanical devices. There are many inorganic materials with piezoelectric effects, such as piezoelectric ceramics, aluminum nitride, and zinc oxide. They all have very high piezoelectric coefficients and large piezoelectric response ranges. The characteristics of high hardness and low tenacity make inorganic piezoelectric materials unsuitable for flexible devices that require frequent bending. Polyvinylidene fluoride (PVDF) and its derivatives are the most popular materials used in flexible electromechanical devices in recent years and have high flexibility, high sensitivity, high ductility, and a certain piezoelectric coefficient. Owing to increasing the piezoelectric coefficient of PVDF, researchers are committed to optimizing PVDF materials and enhancing their polarity by a series of means to further improve their mechanical–electrical conversion efficiency. This paper reviews the latest PVDF-related optimization materials, related processing and polarization methods, and the applications of these materials such as those in wearable functional devices, chemical sensors, biosensors, and flexible actuator devices for flexible micro-electromechanical devices. We also discuss the challenges of wearable devices based on flexible piezoelectric polymer, consider where further practical applications could be.

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“…Novel, advanced, synthetic polymeric biomaterials have attracted attention in recent decades due to their processability, morphological characteristics, surface chemistry, and wide range of potential applications in the sector of electronic devices and for biomedical science (i.e., sensors, biosensors, membranes, etc.) [1][2][3]. Among these materials, polyvinylidene fluoride (PVDF) is a semi-crystalline fluoropolymer presenting a number of characteristics that make it a versatile biomaterial: insolubility, low processing temperature, chemical resistance, stability in biological media, in vitro and in vivo nontoxicity [4][5][6][7], piezoelectricity, and pyroelectricity [8,9].…”

Section: Introductionmentioning

confidence: 99%

“…Nevertheless, depending on the application, there usually exists the need for PVDF processed in different shapes. Bulk/pure PVDF and copolymer scaffolds [16], nanofibers [17], membranes [3], and coatings have been produced for a wide range of applications: sensors [1], microelectronics [18], optoelectronics [19], biosensors [2], and bio-medical technology [4]. To obtain the abovementioned structures, methods such as spin coating [8], electrospinning electrospray [16,17], immersion precipitations [20], and pulsed laser deposition (PLD) [21] have been employed.…”

Section: Introductionmentioning

confidence: 99%

Induced Hydrophilicity and In Vitro Preliminary Osteoblast Response of Polyvinylidene Fluoride (PVDF) Coatings Obtained via MAPLE Deposition and Subsequent Thermal Treatment

et al. 2020

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Recent advancements in biomedicine have focused on designing novel and stable interfaces that can drive a specific cellular response toward the requirements of medical devices or implants. Among these, in recent years, electroactive polymers (i.e., polyvinylidene fluoride or PVDF) have caught the attention within the biomedical applications sector, due to their insolubility, stability in biological media, in vitro and in vivo non-toxicity, or even piezoelectric properties. However, the main disadvantage of PVDF-based bio-interfaces is related to the absence of the functional groups on the fluoropolymer and their hydrophobic character leading to a deficiency of cell adhesion and proliferation. This work was aimed at obtaining hydrophilic functional PVDF polymer coatings by using, for the first time, the one-step, matrix-assisted pulsed evaporation (MAPLE) method, testing the need of a post-deposition thermal treatment and analyzing their preliminary capacity to support MC3T3-E1 pre-osteoblast cell survival. As osteoblast cells are known to prefer rough surfaces, MAPLE deposition parameters were studied for obtaining coatings with roughness of tens to hundreds of nm, while maintaining the chemical properties similar to those of the pristine material. The in vitro studies indicated that all surfaces supported the survival of viable osteoblasts with active metabolisms, similar to the “control” sample, with no major differences regarding the thermally treated materials; this eliminates the need to use a secondary step for obtaining hydrophilic PVDF coatings. The physical-chemical characteristics of the thin films, along with the in vitro analyses, suggest that MAPLE is an adequate technique for fabricating PVDF thin films for further bio-applications.

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A new biosensor based on PVDF film for detection of nucleic acids

Cited by 23 publications

References 15 publications

Lead-Free Piezoelectric Diaphragm Biosensors Based on Micro-Machining Technology and Chemical Solution Deposition

Lead-Free Piezoelectric Diaphragm Biosensors Based on Micro-Machining Technology and Chemical Solution Deposition

Composites, Fabrication and Application of Polyvinylidene Fluoride for Flexible Electromechanical Devices: A Review

Induced Hydrophilicity and In Vitro Preliminary Osteoblast Response of Polyvinylidene Fluoride (PVDF) Coatings Obtained via MAPLE Deposition and Subsequent Thermal Treatment

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