A new biodegradable bone wax substitute with the potential to be used as a bone filling material

Höffmann, Bettina; Volkmer, Elias; Kokott, Andreas; Weber, Markus; Hamisch, Sabine; Schieker, Matthias; Mutschler, Wolf; Ziegler, G.

doi:10.1039/b707992n

Cited by 37 publications

(31 citation statements)

References 15 publications

(12 reference statements)

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“…A strong correlation between the degree of a capsular contracture and the amount of bacterial colonisation could also be shown, and S. epidermidis was the most commonly found bacteria. 6,13,27,[42][43][44][45][46] Based on the results of our previous study evaluating the bactericidal effect of a newly invented copper-loaded coating on silicone breast implants, 26 we investigated the effect of coatings with different copper concentrations on the adherence and viability of S. epidermidis. The surface characteristics of the coated silicone specimens before and after different durations of artificial aging were characterised in defining SFE and R a .…”

Section: Discussionmentioning

confidence: 99%

“…This study was conducted because reducing bacterial adhesion and biofilm formation on silicone materials with antiadhesive and bactericidal coatings may be essential in preventing implant infections and even capsular contractions around implants. 13,42 The artificial aging of implants by thermocycling is a common method for simulating in vivo aging of implants. 47,48 After different aging durations, implants were incubated with a human isolate of S. epidermidis to imitate the natural contamination of silicone specimens for our in vitro study, a method that has proven to be valuable before.…”

Section: Discussionmentioning

confidence: 99%

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Effectiveness of antibacterial copper additives in silicone implants

Gosau¹,

Bürgers

Vollkommer³

et al. 2012

J Biomater Appl

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Staphylococcus epidermidis plays a major role in capsular contractures of silicone breast implants. This in vitro study evaluates the antibacterial effect of copper on S. epidermidis in silicone implants. Specimens of a silicone material used for breast augmentation (Cu0) and specimens coated with different copper concentrations (Cu1, Cu2) were artificially aged. Surface roughness and surface free energy were assessed. The specimens were incubated in an S. epidermidis suspension. We assessed the quantification and the viability of adhering bacteria by live/dead cell labeling with fluorescence microscopy. Additionally, inhibition of bacterial growth was evaluated by agar diffusion, broth culture, and quantitative culture of surface bacteria. No significant differences in surface roughness and surface free energy were found between Cu0, Cu1 and Cu2. Aging did not change surface characteristics and the extent of bacterial adhesion. Fluorescence microscopy showed that the quantity of bacteria on Cu0 was significantly higher than that on Cu1 and Cu2. The ratio of dead to total adhering bacteria was significantly lower on Cu0 than on Cu1 and Cu2, and tended to be higher for Cu2 than for Cu1. Quantitative culture showed equal trends. Copper additives seem to have anti-adherence and bactericidal effects on S. epidermidis in vitro.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Effectiveness of antibacterial copper additives in silicone implants

Gosau¹,

Bürgers

Vollkommer³

et al. 2012

J Biomater Appl

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“…7 Chemical formulas of nonbiodegradable synthetic hydrogels Fig. 8 Chemical formulas of biodegradable synthetic hydrogels hydrogels, for healing wound surfaces, because they retain the wound exudates in their gel network (Hoffmann et al 2007;Weiss and Fatimi 2009).…”

Section: Hydrogelsmentioning

confidence: 99%

Biomaterials Obtained by Gelation

Pierre¹

2016

Handbook of Sol-Gel Science and Technology

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“…Initially HA was combined with hemostatic polymers to improve their limited osteoconductivity. For example, Hoffmann fabricated a HA/starch/chitosan composite hemostatic material, proposed to be a substitute for bone wax or even as a bone filling material for orthopedic surgery applications [7]. After that, researcher noticed the presence of HA not only improve the composite's bone regeneration ability, but also enhance its blood clotting activity.…”

Section: Introductionmentioning

confidence: 99%

Hydroxyapatite: a promising hemostatic component in orthopaedic applications

Yin¹,

Zhou²,

Ni³

et al. 2017

Biol Eng Med

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Agent with both great blood clotting activity and bone regeneration ability is deserved to replace conventional bone wax. Recently, hydroxyapatite (HA) has attracted interests from researchers with its both hemostatic and bone healing functions. In present work, the blood clotting activity comparisons of HA to other potential bone repairing materials including calcium silicate, calcium combined attapulgite, calcium tripolyphosphate, and chitosan were carried out to show HA as a recommended hemostatic component to replace bone wax. In addition, the impacts of HA synthesis routes on its blood clotting activity were evaluated, indicating increase of surface area as well as active Ca 2+ of HA can greatly enhance blood clotting. With these attributes, it is expected HA can be a promising component in fabricating hemostatic materials in orthopedic applications as alternatives to bone wax.

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A new biodegradable bone wax substitute with the potential to be used as a bone filling material

Cited by 37 publications

References 15 publications

Effectiveness of antibacterial copper additives in silicone implants

Effectiveness of antibacterial copper additives in silicone implants

Biomaterials Obtained by Gelation

Hydroxyapatite: a promising hemostatic component in orthopaedic applications

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