A new bioavailability enhancement strategy of curcumin via self-assembly nano-complexation of curcumin and bovine serum albumin

Yu, Hong; Nguyen, Minh-Hiep; Cheow, Wean Sin; Hadinoto, Kunn

doi:10.1016/j.msec.2017.02.018

Cited by 35 publications

(19 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…With respect to the spectrum of Gal-BSA-Cur NPs shown in Figure 3E, the related peak to Cur, a shift from 3,506 to 3,421 cm −1 , was observed, and the valley of 3,421 cm −1 became wider, thereby indicating an enhanced hydrogen bonding. 37,38 Meanwhile, the peaks of Cur at 1,629, 1,601, and 1,510 cm −1 slightly shifted to 1,630, 1,586, and 1,516 cm −1 , respectively. In addition, the absorption peak of Amide III at 1,243 cm −1 shifted to 1,264 cm −1 .…”

mentioning

confidence: 93%

Curcumin-loaded galactosylated BSA nanoparticles as targeted drug delivery carriers inhibit hepatocellular carcinoma cell proliferation and migration

Huang

et al. 2018

IJN

View full text Add to dashboard Cite

BackgroundThe main objective of this study was to develop novel BSA nanoparticles (BSA NPs) for improving the bioavailability of curcumin as an anticancer drug, and those BSA NPs were galactosylated for forming the curcumin-loaded galactosylated BSA nanoparticles (Gal-BSA-Cur NPs), thus enhancing their ability to target asialoglycoprotein receptor (ASGPR) overexpressed on hepatocellular carcinoma (HCC) cells.Materials and methodsGal-BSA-Cur NPs were prepared by the desolvation method and showed a spherical shape and well distribution with the average particle size of 116.24 nm.ResultsIn vitro drug release assay exhibited that Gal-BSA-Cur NPs had higher release rates and improved the curcumin solubility. Cell uptake studies confirmed that Gal-BSA-Cur NPs could selectively recognize receptors on the surface of HCC (HepG2) cells and improve internalization ability of drug compared with BSA NPs-loaded curcumin (BSA-Cur NPs), which might be due to high affinity to galactose. Further, the effects of Gal-BSA-Cur NPs were evaluated by cytotoxicity assay, crystal violet assay, cell apoptosis assay, and wound healing assay, respectively, which revealed that Gal-BSA-Cur NPs could inhibit HepG2 cells proliferation, induce cell apoptosis, and inhibit cell migration.ConclusionImmunofluorescence staining has proved that the effects of Gal-BSA-Cur NPs related to the suppression of the nuclear factor κB-p65 (NF-κB-p65) expression in HepG2 cell nucleus. Therefore, these results indicate that novel Gal-BSA-Cur NPs are potential candidates for targeted curcumin delivery to HCC cells.

show abstract

mentioning

confidence: 93%

Curcumin-loaded galactosylated BSA nanoparticles as targeted drug delivery carriers inhibit hepatocellular carcinoma cell proliferation and migration

Huang

et al. 2018

IJN

View full text Add to dashboard Cite

show abstract

“…Among them, the pharmacological activity of curcumin, an index substance of turmeric, has been reported through many studies [ 6 , 7 , 8 ]. However, curcumin, a yellow hydrophobic polyphenolic component extracted from turmeric has limited applications due to poor solubility and toxicity at high concentrations [ 9 , 10 , 11 ]. Moreover, its low bioavailability in the body remains as a major issue.…”

Section: Introductionmentioning

confidence: 99%

Cytotoxicity Evaluation of Turmeric Extract Incorporated Oil-in-Water Nanoemulsion

Yoon

Zhang

Kang

et al. 2018

IJMS

View full text Add to dashboard Cite

To overcome the drawbacks of conventional drug delivery system, nanoemulsion have been developed as an advanced form for improving the delivery of active ingredients. However, safety evaluation is crucial during the development stage before the commercialization. Therefore, the aim of this study was to evaluate the cytotoxicity of two types of newly developed nanoemulsions. Turmeric extract-loaded nanoemulsion powder-10.6 (TE-NEP-10.6, high content of artificial surfactant Tween 80), which forms the optimal nanoemulsion, and the TE-NEP-8.6 made by increasing the content of natural emulsifier (lecithin) to reduce the potential toxicity of nanoemulsion were cultured with various cells (NIH3T3, H9C2, HepG2, hCPC, and hEPC) and the changes of each cell were observed followed by nanoemulsion treatment. As a result, the two nanoemulsions (TE-NEP-10.6 and TE-NEP-8.6) did not show significant difference in cell viability. In the case of cell line (NIH3T3, H9C2, and HepG2), toxicity was not observed at an experimental concentration of less than 1 mg/mL, however, the cell survival rate decreased in a concentration dependent manner in the case of primary cultured cells. These results from our study can be used as a basic data to confirm the cell type dependent toxicity of nanoemulsion.

show abstract

“…Several different nanocurcumin preparations have been made and tested for in vitro as well as in vivo effects and toxicities [26,27,28]. The nano particle formulations of curcumin have been shown to improve bioavailability and therapeutic potential of curcumin and its analogues and can be considered a medium of choice for delivery of curcuminoids [29,30,31,32,33].…”

Section: Introductionmentioning

confidence: 99%

Bioactivity of Curcumin on the Cytochrome P450 Enzymes of the Steroidogenic Pathway

Castaño

Parween

Pandey

2019

IJMS

View full text Add to dashboard Cite

Turmeric, a popular ingredient in the cuisine of many Asian countries, comes from the roots of the Curcuma longa and is known for its use in Chinese and Ayurvedic medicine. Turmeric is rich in curcuminoids, including curcumin, demethoxycurcumin, and bisdemethoxycurcumin. Curcuminoids have potent wound healing, anti-inflammatory, and anti-carcinogenic activities. While curcuminoids have been studied for many years, not much is known about their effects on steroid metabolism. Since many anti-cancer drugs target enzymes from the steroidogenic pathway, we tested the effect of curcuminoids on cytochrome P450 CYP17A1, CYP21A2, and CYP19A1 enzyme activities. When using 10 µg/mL of curcuminoids, both the 17α-hydroxylase as well as 17,20 lyase activities of CYP17A1 were reduced significantly. On the other hand, only a mild reduction in CYP21A2 activity was observed. Furthermore, CYP19A1 activity was also reduced up to ~20% of control when using 1–100 µg/mL of curcuminoids in a dose-dependent manner. Molecular docking studies confirmed that curcumin could dock onto the active sites of CYP17A1, CYP19A1, as well as CYP21A2. In CYP17A1 and CYP19A1, curcumin docked within 2.5 Å of central heme while in CYP21A2 the distance from heme was 3.4 Å, which is still in the same range or lower than distances of bound steroid substrates. These studies suggest that curcuminoids may cause inhibition of steroid metabolism, especially at higher dosages. Also, the recent popularity of turmeric powder as a dilatory supplement needs further evaluation for the effect of curcuminoids on steroid metabolism. The molecular structure of curcuminoids could be modified to generate better lead compounds with inhibitory effects on CYP17A1 and CYP19A1 for potential drugs against prostate cancer and breast cancer.

show abstract

A new bioavailability enhancement strategy of curcumin via self-assembly nano-complexation of curcumin and bovine serum albumin

Cited by 35 publications

References 29 publications

Curcumin-loaded galactosylated BSA nanoparticles as targeted drug delivery carriers inhibit hepatocellular carcinoma cell proliferation and migration

Curcumin-loaded galactosylated BSA nanoparticles as targeted drug delivery carriers inhibit hepatocellular carcinoma cell proliferation and migration

Cytotoxicity Evaluation of Turmeric Extract Incorporated Oil-in-Water Nanoemulsion

Bioactivity of Curcumin on the Cytochrome P450 Enzymes of the Steroidogenic Pathway

Contact Info

Product

Resources

About